611 research outputs found
Trivalent Influenza Vaccine Adverse Event Analysis Based On MedDRA System Organ Classes Using VAERS Data
We studied serious reports following influnza vaccine from VAERS database in year 2011. Our statistical analyses revealed differences of reactions among different age groups and between genders. The results may lead to additional studies to uncover factors contributing to the individual differences in susceptibility to influenza infection
1-(BenzylÂideneamino)pyridinum iodide
In the title compound, C12H11N2
+·I−, the aromatic rings are oriented at a dihedral angle of 73.40 (3)°. In the crystal structure, π–π contacts between the pyridine rings and the benzene and pyridine rings [centroid–centroid distances = 3.548 (3) and 4.211 (3) Å] may stabilize the structure
One Step Quick Detection of Cancer Cell Surface Marker by Integrated NiFe-based Magnetic Biosensing Cell Cultural Chip
RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiFe-based magnetic biosensing cell chip combined with functionalized magnetic nanoparticles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cultured on the NiFe-based magnetic biosensing chip and distinguish the amount of cell surface receptor-integrin. Cell lines such as Calu3, Hela, A549, CaFbr, HEK293 and HUVEC exhibiting different integrin expression were chosen as test samples. Calu3, Hela, HEK293 and HUVEC cells were successfully identified. This approach has advantages in the qualitative screening test. Compared with traditional method, it is fast, sensitive, low cost, easy-operative, and needs very little human intervention. The novel method has great potential in applications such as fast clinical cell surface marker detection, and diagnosis of early cancer, and can be easily extended to other biomedical applications based on molecular recognition
Different Bacterial Communities Involved in Peptide Decomposition between Normoxic and Hypoxic Coastal Waters
RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiFe-based magnetic biosensing cell chip combined with functionalized magnetic nanoparti- cles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cul- tured on the NiFe-based magnetic biosensing chip and distinguish the amount of cell surface receptor-integrin. Cell lines such as Calu3, Hela, A549, CaFbr, HEK293 and HUVEC exhibiting different integrin expression were chosen as test samples. Calu3, Hela, HEK293 and HUVEC cells were successfully identified. This approach has advantages in the qualitative screening test. Compared with traditional method, it is fast, sensitive, low cost, easy-operative, and needs very little human intervention. The novel method has great potential in applications such as fast clinical cell surface marker detection, and diagnosis of early cancer, and can be easily extended to other biomedical applications based on molecular recognition
Identifying the Riemann zeros by periodically driving a single qubit
The Riemann hypothesis, one of the most important open problems in pure
mathematics, implies the most profound secret of prime numbers. One of the most
interesting approaches to solve this hypothesis is to connect the problem with
the spectrum of the physical Hamiltonian of a quantum system. However, none of
the proposed quantum Hamiltonians have been experimentally feasible.Here, we
report the first experiment to identify the first non-trivial zeros of the
Riemann zeta function and the first two zeros of P\'olya's fake zeta function,
using a novel Floquet method, through properly designed periodically driving
functions. According to this method, the zeros of these functions are
characterized by the occurrence of crossings of quasi-energies when the
dynamics of the system are frozen. The experimentally obtained zeros are in
excellent agreement with their exact values. Our study provides the first
experimental realization of the Riemann zeros, which may provide new insights
into this fundamental mathematical problem.Comment: 5 pages, 7 figure
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