Correlation between periostin and SNCG and esophageal cancer invasion, infiltration and apoptosis

AbstractObjectiveTo investigate the correlation between periostin and SNCG and esophageal cancer invasion, infiltration and apoptosis.MethodsA total of 78 cases esophageal surgical resection specimens were collected, expression of periostin and SNCG in esophageal cancer were detected. Effect of periostin and SNCG in esophageal carcinoma invasion and infiltration was analyzed.ResultsThe upregulated rate of periostin had significant difference in esophageal cancer tissues (39.74%), adjacent tissues (17.86%) and normal tissues (0.00%); The positive expression rates of SNCG had significant difference in esophageal cancer tissues (61.54%), adjacent tissues (32.14%) and normal tissues (1.96%); The upregulated rate of periostin had a significant correlation with lymph node metastasis, adventitia invasion, TNM stage; The positive expression rates of SNCG had a significant correlation with differentiation degree, lymph node metastasis, adventitia invasion, TNM stage; Apoptosis index of the positive of expression of SNCG of esophageal cancer tissue (4.541±2.267) was significantly lower than that of the negative expression (7.316±2.582) (P<0.05).ConclusionsSNCG may play an important role in invasion, infiltration and apoptosis of esophageal cancer and serve as target spots in the targeted therapy of esophageal cancer

Effects of dietary supplementation with peony pollen on growth, immune-related gene expression, and antioxidant status of Cyprinus carpio

Peony (Paeonia suffruticosa Andr.) is both ornamental flower and Chinese herbal medicine in China. This study was conducted to investigate the effects of dietary peony pollen on growth performance and immune status of common carp (Cyprinus carpio). Five different diets with 0% (control group), 1%, 2%, 3% and 4 % of peony pollen were designed to feed the fish for 6 weeks. The results indicated that the dietary peony pollen has beneficial effects on growth performance of common carp. In addition, evaluation of the liver antioxidant enzymes activity of total antioxidant capacity (T-AOC), glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT) in 3% peony pollen group, showed significant increase in carps fed peony pollen (P < 0.05), except the malondialdehyde (MDA) activity. The genes expression levels of tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β) and interleukin-1-β (IL1β) in the carps fed peony pollen were obviously decreased compared to the control group (P < 0.05). The expression levels of heat shock protein-70 (Hsp70) were up-regulated significantly in carps fed peony pollen (P < 0.05). Our observations suggest that peony pollen supplementation in the diets has the potential to improve the immune response by activating carp's cellular antioxidant activity and regulating the expression of immune -related genes, which may lead to increased carp tolerance to adverse conditions. Further research is needed on the use of peony pollen to improve disease resistance in fisheries

Substructuring Method in Structural Health Monitoring

In sensitivity-based finite element model updating, the eigensolutions and eigensensitivities are calculated repeatedly, which is a time-consuming process for large-scale structures. In this chapter, a forward substructuring method and an inverse substructuring method are proposed to fulfill the model updating of large-scale structures. In the forward substructuring method, the analytical FE model of the global structure is divided into several independent substructures. The eigensolutions of each independent substructure are used to recover the eigensolutions and eigensensitivities of the global structure. Consequently, only some specific substructures are reanalyzed in model updating and assembled with other untouched substructures to recover the eigensolutions and eigensensitivities of the global structure. In the inverse substructuring method, the experimental modal data of the global structure are disassembled into substructural flexibility. Afterwards, each substructure is treated as an independent structure to reproduce its flexibility through a model-updating process. Employing the substructuring method, the model updating of a substructure can be conducted by measuring the local area of the concerned substructure solely. Finally, application of the proposed methods to a laboratory tested frame structure reveals that the forward and inverse substructuring methods are effective in model updating and damage identification

gg-mode of neutron stars in pseudo-Newtonian gravity

The equation of state (EOS) of nuclear dense matter plays a crucial role in many astrophysical phenomena associated with neutron stars (NSs). Fluid oscillations are one of the most fundamental properties therein. NSs support a family of gravity $g$-modes, which are related to buoyancy. We study the gravity $g$-modes caused by composition gradient and density discontinuity in the framework of pseudo-Newtonian gravity. The mode frequencies are calculated in detail and compared with Newtonian and general-relativistic (GR) solutions. We find that the $g$-mode frequencies in one of the pseudo-Newtonian treatments can approximate remarkably well the GR solutions, with relative errors in the order of $1\%$. Our findings suggest that, with much less computational cost, pseudo-Newtonian gravity can be utilized to accurately analyze oscillation of NSs constructed from an EOS with a first-order phase transition between nuclear and quark matter, as well as to provide an excellent approximation of GR effects in core-collapse supernova (CCSN) simulations.Comment: 14 pages, 13 figures, 6 tables; accepted by PR

Differential isospin-fractionation in dilute asymmetric nuclear matter

The differential isospin-fractionation (IsoF) during the liquid-gas phase transition in dilute asymmetric nuclear matter is studied as a function of nucleon momentum. Within a self-consistent thermal model it is shown that the neutron/proton ratio of the gas phase becomes {\it smaller} than that of the liquid phase for energetic nucleons, although the gas phase is overall more neutron-rich. Clear indications of the differential IsoF consistent with the thermal model predictions are demonstrated within a transport model for heavy-ion reactions. Future comparisons with experimental data will allow us to extract critical information about the momentum dependence of the isovector strong interaction.Comment: Rapid Communication, Phys. Rev. C (2007) in pres

N-Cyclo­hexyl-2-(5-meth­oxy-1H-indol-3-yl)-2-oxoacetamide

In the title compound, C17H20N2O3, the cyclo­hexane ring adopts a chair conformation. In the crystal, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into layers parallel to the ac plane

Effects of Linear-Polarized Near-Infrared Light Irradiation on Chronic Pain

In order to study the efficacy of linear-polarized near-infrared light irradiation (LPNIR) on relieving chronic pain in conjunction with nerve block (NB) or local block (LB), a 3-week prospective, randomized, double-blind, controlled study was conducted to evaluate the pre- and post-therapy pain intensity. Visual analogue scales (VASs) were measured in all patients before and 6 months after therapy visiting the pain clinic during the period of August 2007 to January 2008. A total of 52 patients with either shoulder periarthritis or myofascial pain syndrome or lateral epicondylitis were randomly assigned into two groups by drawing lots. Patients in Group I were treated with NB or LB plus LPNIR; Group II patients, for their part, were treated with the same procedures as in Group I, but not using LPNIR. In both groups, the pain intensity (VAS score) decreased significantly immediately after therapy as compared to therapy. There was a significant difference between the test and control groups immediately after therapy (P < 0.05), while no effect 6 months later. No side effects were observed. It is concluded that LPNIR is an effective and safe modality to treat various chronic pains, which has synergic effects with NB or LB