Against Cyclic Linearization:Scrambling and Numeral Quantifiers in Korean

This paper criticizes Ko's (2007) CL analysis of scrambling. Against her analysis, according to which a case-less numeral quantifier and its host NP comprise a constituent, I adapt Miyagawa's (1989) mutual c-command analysis in tandem with the current minimalist framework (Chomsky 2005), and propose that they do not form a constituent but do enter into an ana-phoric relation. On the other hand, with Ko's (2007) analysis of vP as a Spell-out domain subject to criticism, I show that there are some serious theoretical problems with it. It should be noted that this criticism would apply to Fox & Pesetsky's (2005a) original proposal. Consequently, I will show that the intriguing phenomena observed by Ko (2007) can be reasonably accounted for in the way proposed in this paper

Subacute Neurological Deterioration with Selective Axonal Injury in Patients with Acute Ischemic Stroke following Reperfusion of Middle Cerebral Artery Occlusion

To date, the long-term effects of reperfusion on the salvaged brain tissues have not been addressed in the literature. We report 4 cases presenting subacute neurological deteriorations with selective axonal injury following reperfusion therapies for acute ischemic stroke. Our case series based on 4 patients showed common features distinct from those of early reperfusion injury in that (1) the neurological symptoms developed after 1-2 months of reperfusion therapies, (2) these symptoms were accompanied by the subcortical white matter changes on brain MRI, and (3) these findings were mostly reversible with time. This suggests that axons in the reperfused brain may be vulnerable to further neurological injury

Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B

AbstractSelenoprotein W (SelW) contains a highly reactive selenocysteine (Sec; U) in the CXXU motif corresponding to the CXXC motif in thioredoxin (Trx) and thus it appears to be involved in regulating the cellular redox state. Recent reports on the interaction between SelW and 14-3-3 suggest that SelW may be redox dependently involved in the cell cycle. However, the precise function of SelW has not yet been elucidated. Here, we show that SelW is involved in the G2–M transition, especially in the recovery from G2 arrest after deoxyribonucleic acid (DNA) damage. Knockdown of SelW significantly accumulated phosphorylated cyclin‐dependent kinase (Cdk1), which eventually led to a delay in recovery from G2 arrest. We also found that inactive Cdk1 is caused by the sustained inactivation of CDC25B, which removes the inhibitory phosphate from Cdk1. Our observation from this study reveals that SelW activated CDC25B by promoting the dissociation of 14-3-3 from CDC25B through the reduction of the intramolecular disulfide bond during recovery. We suggest that SelW plays an important role in the recovery from G2 arrest by determining the dissociation of 14-3-3 from CDC25B in a redox-dependent manner

Manual Scaling of Ionograms Measured at Jeju (33.4°N, 126.3°E)

The ionosphere has been monitored by ionosondes for over five decades since the 1960s in Korea. An ionosonde typically produces an ionogram that displays radio echoes in the frequency-range plane. The trace of echoes in the plane can be read either manually or automatically to derive useful ionospheric parameters such as foF2 (peak frequency of the F2 layer) and hmF2 (peak height of the F2 layer). Monitoring of the ionosphere should be routinely performed in a given time cadence, and thus, automatic scaling of an ionogram is generally executed to obtain ionospheric parameters. However, an auto-scaling program can generate undesirable results that significantly misrepresent the ionosphere. In order to verify the degree of misrepresentation by an auto-scaling program, we performed manual scaling of all 35,136 ionograms measured at Jeju (33.43˚N, 126.30˚E) throughout 2012. We compared our manually scaled parameters (foF2 and hmF2) with auto-scaled parameters that were obtained via the ARTIST5002 program. We classified five cases in terms of the erroneous scaling performed by the program. The results of the comparison indicate that the average differences with respect to foF2 and hmF2 between the two methods approximately correspond to 0.03 MHz and 4.1 km, respectively with corresponding standard deviations of 0.12 MHz and 9.58 km. Overall, 36 % of the auto-scaled results differ from the manually scaled results by the first decimal number. Therefore, future studies should be aware of the quality of auto-scaled parameters obtained via ARTIST5002. Hence, the results of the study recommend the use of manually scaled parameters (if available) for any serious applications

Impact of Left Atrial Appendage Morphology on Recurrence in Embolic Stroke of Undetermined Source and Atrial Cardiopathy

Background: The left atrial appendage (LAA) is a major source of thrombus and non-chicken wing (CW). LAA morphology is a risk factor for embolic events in atrial fibrillation. However, the association of non-CW morphology with embolic stroke recurrence is unknown in patients with embolic stroke of undetermined source (ESUS) and atrial cardiopathy.Methods: We conducted retrospective analyses using a prospective institutional stroke registry (2013–2017). Patients with ESUS and atrial cardiopathy were enrolled. Atrial cardiopathy was diagnosed if an increased left atrial diameter (>40 mm, men; >38 mm, women), supraventricular tachycardia, or LAA filling defect on computed tomography (CT) were present. Patients admitted >24 h after onset were excluded. LAA morphology was evaluated using CT and categorized into CW vs. non-CW types. The primary outcome was embolic stroke recurrence. Multivariable Cox proportional hazards models were used to examine the independent association between LAA morphology and outcome.Results: Of 157 patients, 81 (51.6%) had CW LAA morphology. The median follow-up was 41.5 (interquartile range 12.3–58.5) months corresponding to 509.8 patient years. In total, 18 participants experienced embolic stroke recurrences (3.80 per 100 patient-years). Non-CW morphology was more associated with embolic stroke recurrence than CW morphology (hazard ratio (HR), 3.17; 95% confidence interval (CI), 1.13–8.91; p = 0.029). After adjusting for CHA2DS2-VASc score and number of potential embolic sources, non-CW morphology showed an independent association with outcome (adjusted HR, 2.90; 95% CI, 1.02–8.23; p = 0.045).Conclusions: The LAA morphology types may help identify high risk of embolic stroke recurrence in ESUS with atrial cardiopathy. LAA morphology in atrial cardiopathy may provide clues for developing therapies tailored to specific mechanisms