Farmacología de los opioides

En los últimos años se ha avanzado en el conocimiento de la farmacología de los opioides. Los opioides endógenos y exógenos se unen a receptores específicos. Existen cuatro tipos de receptores opioides; mu, kappa, delta y nociceptina. Todos ellos pertenecen a la familia de receptores de membrana acoplados a proteína G. Los opioides se clasifican según su afinidad y eficacia en agonistas puros, agonistas-antagonistas, agonistas parciales y antagonistas. Los principales efectos farmacológicos tras la administración de un agonista son sedación, euforia, analgesia, náusea y vómito, miosis, supresión de la tos, depresión respiratoria, rigidez, estreñimiento, enrojecimiento facial y prurito, retención urinaria y la posibilidad de dependencia (tolerancia y abstinencia). La tolerancia y dependencia física parecen deberse a una regulación por incremento de la adenilciclasa y aumento del AMPc. Los opioides además producen efectos duraderos que parecen relacionados con un aumento de la concentración de factores de transcripción como el CREB y ΔFosB y que son relevantes para las recaídas. Se revisan la farmacocinética de los principales opioides, las interacciones farmacológicas y su utilización en terapéuticaEndogenous and exogenous opioid bind to specific receptors. There are four different types of opioid receptors: mu, kappa, delta and nociceptin. All of them are membrane receptors coupled to protein G. Opioid drugs are classified, taking into account its affinity and efficacy for receptors, in four classes: pure agonists, agonist-antagonists, partial agonists and antagonists. The main pharmacological effects induced by agonists are sedation, euphoria, analgesia, nausea and vomiting, miosis, cough suppression, respiratory depression, truncal rigidity, constipation, face flushing and pruritus, urinary retention, and dependence (tolerance, withdrawal). The upregulation of the AMPc pathway seem responsible for tolerance and withdrawal symptoms. Opioide agonist induce long-lasting neural adaptations that are related to the synthesis of some transcription factors as CREB and ΔFosB, that seem relevant in relapse. Pharmacokinetic, drug interactions and therapeutic indications are reviewe

The Covid-19 Pandemic Era As A Unique Historical Period For College Students Negotiating Romance, Dating And Sexual Relationships: Predictors Of High Self-efficacy For Engaging In Safer Sex Practices

The problem this study addressed involves how college students since the year 2020 in the U.S. have been negotiating romance, dating, and sexual relationships in the unique historical period of the COVID-19 pandemic. Further, this study addressed the problem of needing to determine how the pandemic may have disrupted college students’ intimate sexual experiences—and impacted their mental health, physical health, and experiences of social support. The main purpose was to identify significant predictors of the study outcome variable of a higher rating of self-efficacy for engaging in safer sexual behaviors. An additional purpose of the study was to determine if there were significant differences in students’ mean ratings—when comparing mean scores for 5 time periods (i.e. 1-2018-2019/freshman year before the pandemic; 2-2019-2020/second semester of sophomore year during pandemic; 3-2020-2021/junior year during pandemic; 4-2021-2022/senior year during the pandemic; and, 5-currently, especially the past 3 months)—for physical health, mental health, social support, and level of involvement in romantic, intimate, serious dating, or sexual relationships. Overall, comparisons for time periods found deterioration during the pandemic years with some signs of improvement by the current time period of Spring 2023. Findings showed females had higher self-efficacy to perform safer sexual behaviors, but also that survey respondents who lived independently had higher self-efficacy to perform safer sexual behaviors, those who had a COVID-19 diagnosis in the past two years had higher self-efficacy to perform safer sexual behaviors, and survey respondents whose college did have a sexual assault media campaign had higher self-efficacy to perform safer sexual behaviors. The results of the backwards stepwise regression found that higher self-efficacy to perform safer sexual behaviors was significantly predicted by higher age, higher income, higher BMI, lower social support, higher current romantic involvement, higher exposure to sexual assault information on campus, lower alcohol/drug use during sex, and higher stage of change for engagement in safer sex—as a global mean score capturing four risk reduction behaviors; and, 56.4% of the variance was explained by the model. Implications and recommendations are discussed with a focus on the need for longitudinal studies with a nationally representative sample

An investigation of eyes-free spatial auditory interfaces for mobile devices: supporting multitasking and location-based information

Auditory interfaces offer a solution to the problem of effective eyes-free mobile interactions. However, a problem with audio, as opposed to visual displays, is dealing with multiple simultaneous information streams. Spatial audio can be used to differentiate between different streams by locating them into separate spatial auditory streams. In this thesis, we consider which spatial audio designs might be the most effective for supporting multiple auditory streams and the impact such spatialisation might have on the users' cognitive load. An investigation is carried out to explore the extent to which 3D audio can be effectively incorporated into mobile auditory interfaces to offer users eyes-free interaction for both multitasking and accessing location-based information. Following a successful calibration of the 3D audio controls on the mobile device of choice for this work (the Nokia N95 8GB), a systematic evaluationof 3D audio techniques is reported in the experimental chapters of this thesis which considered the effects of multitasking, multi-level displays, as well as differences between egocentric and exocentric designs. One experiment investigates the implementation and evaluation of a number of different spatial (egocentric) and non-spatial audio techniques for supporting eyes-free mobile multitasking that included spatial minimisation. The efficiency and usability of these techniques was evaluated under varying cognitive load. This evaluation showed an important interaction between cognitive load and the method used to present multiple auditory streams. The spatial minimisation technique offered an effective means of presenting and interacting with multiple auditory streams simultaneously in a selective-attention task (low cognitive load) but it was not as effective in a divided-attention task (high cognitive load), in which the interaction benefited significantly from the interruption of one of the stream. Two further experiments examine a location-based approach to supporting multiple information streams in a realistic eyes-free mobile environment. An initial case study was conducted in an outdoor mobile audio-augmented exploratory environment that allowed for the analysis and description of user behaviour in a purely exploratory environment. 3D audio was found to be an effective technique to disambiguate multiple sound sources in a mobile exploratory environment and to provide a more engaging and immersive experience as well as encouraging an exploratory behaviour. A second study extended the work of the previous case study by evaluating a number of complex multi-level spatial auditory displays that enabled interaction with multiple location-based information in an indoor mobile audio-augmented exploratory environment. It was found that a consistent exocentric design across levels failed to reduce workload or increase user satisfaction, so this design was widely rejected by users. However, the rest of spatial auditory displays tested in this study encouraged an exploratory behaviour similar to that described in the previous case study, here further characterised by increased user satisfaction and low perceived workload

Hernioplastía inguinal laparoscópica con técnica transabdominal preperitoneal en pacientes postquirúrgicos del Hospital Escuela Carlos Roberto Huembes Managua, Nicaragua Enero 2013-Diciembre 2018

Con el objetivo de analizar la evolución postquirúrgica de hernioplastía inguinal laparoscópica con técnica transabdominal preperitoneal en pacientes postquirúrgicos del Hospital Escuela Carlos Roberto Huembes enero 2013- diciembre 2018 se realizó un estudio descriptivo, correlacional y analítico. Fueron analizados demografía, factores de riesgo, clasificación de hernias según Nyhus asociación entre dolor postquirúrgico y tipo de hernia, complicaciones postquirúrgicas y tipo de hernia encontrada, relación entre factores de riesgo y complicaciones. Los análisis estadísticos efectuados fueron descriptivos, pruebas de correlación paramétricas y no Paramétricas. Todos los análisis se realizaron con el programa SPSS 21. Del análisis y discusión de los resultados obtenidos, se alcanzaron las siguientes conclusiones: media de edad encontrada fue 42 años y el principal factor de riesgo obesidad, el tipo de hernia encontrado en mayor porcentaje fue la Nyhus tipo II, el mayor porcentaje de pacientes postquirúrgicos no presento dolor y de los que presentaron se asoció al tipo de hernia nyhus II, las complicaciones encontradas fueron un total de 4 las cuales dos correspondían a hematoma en paciente con hernia Nyhus tipo II, un seroma y una recidiva que correspondían a hernia Nyhus tipo III lo cual orienta no existe relación entre la complicación y el tipo de hernia. Los pacientes que presentaron complicaciones postquirúrgicas como hematoma que fueron dos, tenían como factores de riesgo la obesidad, hipertensión arterial y eran fumadore

Aspects of T-duality in Open Strings

We study T-duality for open strings in various $D$-manifolds in the approach of canonical transformations. We show that this approach is particularly useful to study the mapping of the boundary conditions since it provides an explicit relation between initial and dual variables. We consider non-abelian duality transformations and show that under some restrictions the dual is a curved $(d-{\rm dim}G-1)$ D-brane, where $d$ is the dimension of the space-time and $G$ the non-abelian symmetry group. The generalization to $N=1$ supersymmetric sigma models with abelian and non-abelian isometries is also considered.Comment: 24 pags, latex file, some references added (version to be published in Nucl. Phys. B

Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes

Human heme oxygenase-1 (hHO-1) catalyzes the O2- dependent oxidation of heme to biliverdin, CO, and free iron. Previous work indicated that electrophilic addition of the terminal oxygen of the ferric hydroperoxo complex to the -meso-carbon gives 5-hydroxyheme. Earlier efforts to block this reaction with a 5-methyl substituent failed, as the reaction still gave biliverdin IX . Surprisingly, a 15-methyl substituent caused exclusive cleavage at the -meso- rather than at the normal, unsubstituted -meso-carbon. No CO was formed in these reactions, but the fragment cleaved from the porphyrin eluded identification. We report here that hHO-1 cleaves 5-phenylheme to biliverdin IX and oxidizes 15- phenylheme at the -meso position to give 10-phenylbiliverdin IX . The fragment extruded in the oxidation of 5-phenylheme is benzoic acid, one oxygen of which comes from O2 and the other from water. The 2.29- and 2.11-Å crystal structures of the hHO-1 complexes with 1- and 15-phenylheme, respectively, show clear electron density for both the 5- and 15-phenyl rings in both molecules of the asymmetric unit. The overall structure of 15-phenylheme-hHO-1 is similar to that of heme-hHO-1 except for small changes in distal residues 141–150 and in the proximal Lys18 and Lys22. In the 5-phenylhemehHO-1 structure, the phenyl-substituted heme occupies the same position as heme in the heme-HO-1 complex but the 5-phenyl substituent disrupts the rigid hydrophobic wall of residues Met34, Phe214, and residues 26–42 near the -meso carbon. The results provide independent support for an electrophilic oxidation mechanism and support a role for stereochemical control of the reaction regiospecificity.Fil: Wang, Jingling. University of California; Estados UnidosFil: Niemevz, Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Lad, Latesh. University of California; Estados UnidosFil: Huang, Liusheng. University of California; Estados UnidosFil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Buldain, Graciela Yolanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Poulos, Thomas L.. University of California; Estados UnidosFil: Ortiz de Montellano, Paul R.. University of California; Estados Unido

Perceived discrimination and self-rated health in the immigrant population of the Basque Country, Spain

Objective To examine the effect of perceived discrimination and self-rated health among the immigrant population in the Basque Country, Spain, and determine whether this effect varies according to region of origin, age, sex and education. Methods Descriptive cross-sectional study. The study population included immigrants aged 18 and older residing in the Basque Country. Data from the 2014 Foreign Immigrant Population Survey (n=3,456) were used. Log-binomial regression was used to quantify the association between perceived discrimination and self-rated health before and after checking for the selected characteristics. Results Almost 1 in 10 immigrant adults reports perceiving discrimination. In adjusted analyses, the immigrants perceiving discrimination were almost were 1.92 more likely to rate their health as poor (prevalence ratio: 1.92; 95% CI: 1.44–2.56) than those who did not report discrimination. This association did not vary according to region of origin, age, sex or educational level. Conclusions Perceived discrimination shows a consistent relationship with perceived health. Moreover, this association did not depend on the region of origin, age, sex or educational level of immigrants. These results show the need for implementing inclusive policies to eliminate individual and institutional discrimination and reduce health inequalities between the immigrant and native populations

Removal of TiO 2 nanoparticles from water by low pressure pilot plant filtration

Rising use of nanoparticles in manufacturing as well as in commercial products bring issues related to environmental release and human exposure. A large amount of TiO2 nanoparticles will eventually reach wastewater treatment plants. Low pressure membrane filtration has been suggested as a feasible treatment of water streams. This study investigated first at laboratory scale the influence of: i) membrane material, ii) pore size and iii) water chemistry on nTiO2 removal. TiO2 retention was governed by the cake layer formation mechanism and significant retention of nanoparticles was observed even for filters having considerably larger pores than nTiO2. PVDF showed a great potential for nTiO2 rejection. Additionally, filtration pilot plant experiments were carried out using PVDF membranes (0.03 and 0.4 μm pore size). The release of nTiO2 in the pilot scale filtration system was always above the instrumental detection limit (> 1.5 μg/L) and in most cases below 100 μg/L regardless of the pore size and applied conditions. The nTiO2 membrane breakthrough predominantly occurred in the first few minutes after backwashes and ceased when the cake layer was formed. Ultrafiltration and microfiltration were comparable with rejection of nTiO2 above 95% at similar permeate flow rates. Nevertheless, ultrafiltration is more promising than microfiltration because it allowed longer operation times between backwash cycles.This work was funded by the Provincial Government of Bizkaia (6-12-TK-2010-0013)

Communications in flexible supervisor for laboratory research in renewable energy

In laboratories new systems are created where researchers hope to obtain improved functions at a reasonable cost. In them, specialists need efficient tools that offer better performance and flexible features. This paper designs and implements a SCADA system for GERA laboratory (Scientific Group for Applied Renewable Energy at the University of Oriente) adjusted to the inherent characteristics of flexibility and functionality required in research centers. All these features are supported in an efficient communication system with the implementation of various protocols and novel solutions for this type of systems for monitoring and control. It verifies and validates the system for formal methods