HepG2細胞の増殖抑制におけるアミノレブリン酸の効果

The importance of apoptosis response on cancer cells has become a focal point of cancer research. However, little information is available on the apoptotic effects of aminolevulinic acid （ALA）. The purpose of this study was to explore the influence of ALA on HepG2 cell proliferation. HepG2 cells were cultivated for four days in media supplemented with ALA （ALA+） and without ALA （ALA-）. Phase contrast micrographs were taken every day, and the number of cells was counted. Cytochrome C oxidase activity was analyzed in the mitochondrial membrane, as well as outside the membrane. Compared with ALA-, ALA+ showed suppression of HepG2 cell proliferation and increased cytochrome C oxidase activity outside the mitochondrial membrane. The present results suggest that ALA elevate apoptosis by increasing release of cytochrome C from mitochondria

Identification of New Neutron-Rich Isotopes in the Rare-Earth Region Produced by 345 MeV/nucleon 238^{238}U

International audienceA search for new isotopes in the neutron-rich rare-earth region has been carried out using a 345 MeV=nucleon 238U beam at the RIKEN Nishina Center RI Beam Factory. Fragments produced were analyzed and identified using the BigRIPS in-flight separator. We observed a total of 29 new neutron-rich isotopes: 153Ba, 154,155,156La, 156,157,158Ce, 156,157,158,159,160,161Pr, 162,163Nd, 164,165Pm, 166,167Sm, 169Eu, 171Gd, 173,174Tb, 175,176Dy, 177,178Ho, and 179,180Er