Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma

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Pathway analysis of complex diseases for GWAS, extending to consider rare variants, multi-omics and interactions

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Association of High Myopia with Crystallin Beta A4 (CRYBA4) Gene Polymorphisms in the Linkage-Identified MYP6 Locus

Background: Myopia is the most common ocular disorder worldwide and imposes tremendous burden on the society. It is a complex disease. The MYP6 locus at 22 q12 is of particular interest because many studies have detected linkage signals at this interval. The MYP6 locus is likely to contain susceptibility gene(s) for myopia, but none has yet been identified. Methodology/Principal Findings: Two independent subject groups of southern Chinese in Hong Kong participated in the study an initial study using a discovery sample set of 342 cases and 342 controls, and a follow-up study using a replication sample set of 316 cases and 313 controls. Cases with high myopia were defined by spherical equivalent ⠤ -8 dioptres and emmetropic controls by spherical equivalent within ±1.00 dioptre for both eyes. Manual candidate gene selection from the MYP6 locus was supported by objective in silico prioritization. DNA samples of discovery sample set were genotyped for 178 tagging single nucleotide polymorphisms (SNPs) from 26 genes. For replication, 25 SNPs (tagging or located at predicted transcription factor or microRNA binding sites) from 4 genes were subsequently examined using the replication sample set. Fisher P value was calculated for all SNPs and overall association results were summarized by meta-analysis. Based on initial and replication studies, rs2009066 located in the crystallin beta A4 (CRYBA4) gene was identified to be the most significantly associated with high myopia (initial study: P = 0.02; replication study: P = 1.88e-4; meta-analysis: P = 1.54e-5) among all the SNPs tested. The association result survived correction for multiple comparisons. Under the allelic genetic model for the combined sample set, the odds ratio of the minor allele G was 1.41 (95% confidence intervals, 1.21-1.64). Conclusions/Significance: A novel susceptibility gene (CRYBA4) was discovered for high myopia. Our study also signified the potential importance of appropriate gene prioritization in candidate selection. © 2012 Ho et al.published_or_final_versio

Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma

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Predictors of the Extent of Carotid Atherosclerosis in Patients Treated with Radiotherapy for Nasopharyngeal Carcinoma

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Precipitation of PEG/Carboxyl-modified gold nanoparticles with magnesium pyrophosphate : a new platform for real-time monitoring of loop-mediated isothermal amplification

2016-2017 > Academic research: refereed > Publication in refereed journal201804_a bcmaVersion of RecordRGCOthersRGC: 501413Others: PGMS Project IDs: P0009500 and P0009150Publishe

Association of high myopia with crystallin beta A4 (CRYBA4) gene polymorphisms in the linkage-identified MYP6 locus

Author name used in this publication: Maurice K. H. Yap2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Genetic susceptibility to refractive error : association of vasoactive intestinal peptide receptor 2 (VIPR2) with high myopia in Chinese

Author name used in this publication: Maurice K. H. Yap2012-2013 > Academic research: refereed > Publication in refereed journalpublished_fina

Platinum nanoparticles on reduced graphene oxide as peroxidase mimetics for the colorimetric detection of specific DNA sequence

2015-2016 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Evaluation of proteoglycan gene polymorphisms as risk factors in the genetic susceptibility to high myopia

Author name used in this manuscript: Maurice K. H. Yap2011-2012 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe