Pentoxifylline as an Adjunct to Antimicrobial Therapy to Reduce Length of Stay in Infants with Sepsis

Context: Neonatal sepsis is associated with prolonged hospital stay and increased morbidity and mortality despite appropriate antimicrobial therapy. There are discordant results in the existing literature regarding the association between adjunctive pentoxifylline therapy and duration of stay or mortality. Hypothesis: We hypothesize that among preterm infants with blood culture-confirmed sepsis who are treated with pentoxifylline plus appropriate antimicrobial therapy, as compared to infants treated with placebo plus appropriate antimicrobial therapy, median duration of stay in the neonatal intensive care unit will be significantly reduced. Methods: We propose a multicenter, double-blind, placebo-controlled, parallel-group randomized controlled trial to investigate the efficacy of adjunctive pentoxifylline therapy to reduce duration of stay in the neonatal intensive care unit. Significance: Results from this study may identify an agent that can be added to antimicrobial therapy to reduce duration of stay and attenuate the associated morbidity, mortality, and socioeconomic and emotional burdens of neonatal sepsis

Game Theoretical Interactions of Moving Agents

Game theory has been one of the most successful quantitative concepts to describe social interactions, their strategical aspects, and outcomes. Among the payoff matrix quantifying the result of a social interaction, the interaction conditions have been varied, such as the number of repeated interactions, the number of interaction partners, the possibility to punish defective behavior etc. While an extension to spatial interactions has been considered early on such as in the "game of life", recent studies have focussed on effects of the structure of social interaction networks. However, the possibility of individuals to move and, thereby, evade areas with a high level of defection, and to seek areas with a high level of cooperation, has not been fully explored so far. This contribution presents a model combining game theoretical interactions with success-driven motion in space, and studies the consequences that this may have for the degree of cooperation and the spatio-temporal dynamics in the population. It is demonstrated that the combination of game theoretical interactions with motion gives rise to many self-organized behavioral patterns on an aggregate level, which can explain a variety of empirically observed social behaviors

Segregation by Racial and Demographic Group: Evidence from the San Francisco Bay Area

This paper considers residential segregation by race and by type of household in 1970 and 1980. The paper presents entropy indices of segregation for the San Francisco Bay Area and its five metropolitan areas. The methodology permits an investigation of the effects of group definition upon segregation measures, and an analysis of the degree of independence in the segregation of households by race and demographic group. The results indicate that the levels of segregation by race and by household type have declined modestly during the 1970s, at least in this region. More importantly, however, the results indicate a remarkable independence in the spatial distribution of households by race and demographic group. Only a very small fraction of the observed levels of segregation by race could be ’explained’ by the prior partitioning of households by demographic group. The principal results of the analysis are invariant to changes in the definition of racial or household groups

Effects of motifs in music therapy on the attention of children with externalizing behavior problems

Recent studies highlight the role of attention (i.e., executive attention and joint attention) in the negative association between children’s externalizing behavior problems (EBPs) and self-regulation. In music therapy improvisation, “Motifs” represent a repeated and meaningful use of freely improvised or structured music. They have been reported to be effective in drawing attention toward joint musical engagement. This study aimed to examine the effects of clinically derived motifs on the attention of a child with EBPs. Video microanalysis of four therapy sessions was employed. Interaction segments with/without motifs were then selected for analysis: (a) Executive attention measurement: a two-way analysis of variance (ANOVA) was conducted to examine the effects of Motifs (Factor I) across sessions (Factor II) on the duration of interaction segments. (b) Joint attention measurement: another two-way ANOVA investigated the effects of these two factors on the duration of joint attentive responses in each segment. Results showed that (a) the segments with Motifs tended to decrease in duration throughout the sessions, while (b) these segments showed a significant increase in proportions of joint attentional responses. These findings suggest a positive effect of Motifs on enhancing efficiency of joint attention execution over time, indicating the child’s recognition of the Motifs through learning

Reverse discrimination and efficiency in education

This article shows that reverse discrimination policies can find a justification purely on efficiency grounds. We study the optimal provision of education when households belong to different groups, differing in the distribution of the potential to benefit from education among individuals, which is private information. The main result is that high-potential individuals from groups with relatively few high-potential individuals should receive more education than otherwise identical individuals from groups with a more favorable distribution of these benefits

Syncretism and fundamentalism: a comparison

In several ways, syncretism and fundamentalism can be viewed as opposite reactions to the processes of modernization and globalization. Within religious contexts, syncretists and fundamentalists make different choices when confronted with alternatives and with challenges to the accepted practices of daily life. The power dimension is an important aspect for this comparison. But the study of these two modern religious phenomena also points to a similarity with a paradigmatic debate, the contrast between positivist and constructivist approaches. Though the comparison is not the most obvious, there are striking similarities between fundamentalists and positivists, on the one hand, and between constructivists and syncretists, on the other. © 2005 Social Compass

Advancing newborn health: The Saving Newborn Lives initiative

Until recently, newborn health was virtually absent from the global health agenda. Now, assistance agencies, national governments and non-governmental organisations are increasingly addressing this previously neglected issue of close to four million newborns dying every year. The experience of the Saving Newborn Lives initiative documents some of the progress that has been made and the challenges and opportunities that lie ahead. Since the start of the initiative in 2000, targeted research, focused on overcoming the key barriers to improved newborn survival, has demonstrated low-cost, community-based interventions and strategies that can significantly reduce newborn mortality. Building on what has been learned from this and other efforts to date, the challenge now is to reach the millions of newborns still at risk