2D full-waveform modeling of seismic waves in layered karstic media

We have developed a new propagator-matrix scheme to simulate seismic-wave propagation and scattering in a multilayered medium containing karstic voids. The propagator matrices can be found using the boundary element method. The model can have irregular boundaries, including arbitrary free-surface topography. Any number of karsts can be included in the model, and each karst can be of arbitrary geometric shape. We have used the Burton-Miller formulation to tackle the numerical instability caused by the fictitious resonance due to the finite size of a karstic void. Our method was implemented in the frequency-space domain, so frequency-dependent Q can be readily incorporated. We have validated our calculation by comparing it with the analytical solution for a cylindrical void and to the spectral element method for a more complex model. This new modeling capability is useful in many important applications in seismic inverse theory, such as imaging karsts, caves, sinkholes, and clandestine tunnels

Cardiac commitment driven by MyoD expression in pericardial stem cells

Cellular therapy holds immense promise to remuscularize the damaged myocardium but is practically hindered by limited allogeneic sources of cardiac-committed cells that engraft stably in the recipient heart after transplantation. Here, we demonstrate that the pericardial tissue harbors myogenic stem cells (pSCs) that are activated in response to inflammatory signaling after myocardial infarction (MI). The pSCs derived from the MI rats (MI-pSCs) show in vivo and in vitro cardiac commitment characterized by cardiac-specific Tnnt2 expression and formation of rhythmic contraction in culture. Bulk RNA-seq analysis reveals significant upregulation of a panel of genes related to cardiac/myogenic differentiation, paracrine factors, and extracellular matrix in the activated pSCs compared to the control pSCs (Sham-pSCs). Notably, we define MyoD as a key factor that governs the process of cardiac commitment, as siRNA-mediated MyoD gene silencing results in a significant reduction of myogenic potential. Injection of the cardiac-committed cells into the infarcted rat heart leads to long-term survival and stable engraftment in the recipient myocardium. Therefore, these findings point to pericardial myogenic progenitors as an attractive candidate for cardiac cell-based therapy to remuscularize the damaged myocardium

PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

Mutations in PTEN induced kinase 1 (PINK1), a mitochondrial Ser/Thr kinase, cause an autosomal recessive form of Parkinson's disease (PD), PARK6. Here, we report that PINK1 exists as a dimer in mitochondrial protein complexes that co-migrate with respiratory chain complexes in sucrose gradients. PARK6 related mutations do not affect this dimerization and its associated complexes. Using in vitro cell culture systems, we found that mutant PINK1 or PINK1 knock-down caused deficits in mitochondrial respiration and ATP synthesis. Furthermore, proteasome function is impaired with a loss of PINK1. Importantly, these deficits are accompanied by increased α-synclein aggregation. Our results indicate that it will be important to delineate the relationship between mitochondrial functional deficits, proteasome dysfunction and α-synclein aggregation

Episodic Magma Hammers for the 15 January 2022 Cataclysmic Eruption of Hunga Tonga‐Hunga Ha'apai

Abstract Understanding the forces and magma system dynamics on timescales of seconds to minutes remains challenging. In the January 2022 phreatoplinian Hunga Tonga‐Hunga Ha'apai eruption, four remarkably similar seismic subevents within a 5‐min interval occurred during the intensifying early eruptive phase. The subevents are similar in waveforms and durations (∼25 s each). Each subevent begins with an unusual negative P‐wave polarity which is inferred, using full‐wave seismic modeling, to be caused by an upward single‐force mechanism at the volcano created by a magma hammer likely in response to magma flow blockage/constriction during the early part of the eruption as discharge rapidly increased over orders of magnitude with concomitant conduit geometry evolution and instability. Our proposed episodic magma hammer model is consistent with thermodynamic and phase properties of the magmatic mixture, and yields an estimate of conduit mass flow in agreement with vent discharge rates derived from satellite imagery of plume heights

Under the Surface: Pressure-Induced Planetary-Scale Waves, Volcanic Lightning, and Gaseous Clouds Caused by the Submarine Eruption of Hunga Tonga-Hunga Ha’apai Volcano Provide an Excellent Research Opportunity

We present a narrative of the eruptive events culminating in the cataclysmic 15 January 2022 eruption of Hunga Tonga-Hunga Ha’apai Volcano by synthesizing diverse preliminary seismic, volcanological, sound wave, and lightning data available within the first few weeks after the eruption occurred. The first hour of eruptive activity produced fast-propagating tsunami waves, long-period seismic waves, loud audible sound waves, infrasonic waves, exceptionally intense volcanic lightning and an unsteady volcanic plume that transiently reached—at 58 km—the Earth’s mesosphere. Energetic seismic signals were recorded worldwide and the globally stacked seismogram showed episodic seismic events within the most intense periods of phreatoplinian activity, and they correlated well with the infrasound pressure waveform recorded in Fiji. Gravity wave signals were strong enough to be observed over the entire planet in just the first few hours, with some circling the Earth multiple times subsequently. These large-amplitude, long-wavelength atmospheric disturbances come from the Earth’s atmosphere being forced by the magmatic mixture of tephra, melt and gasses emitted by the unsteady but quasi-continuous eruption from 0402±1—1800 UTC on 15 January 2022. Atmospheric forcing lasted much longer than rupturing from large earthquakes recorded on modern instruments, producing a type of shock wave that originated from the interaction between compressed air and ambient (wavy) sea surface. This scenario differs from conventional ideas of earthquake slip, landslides, or caldera collapse-generated tsunami waves because of the enormous (∼1000x) volumetric change due to the supercritical nature of volatiles associated with the hot, volatile-rich phreatoplinian plume. The time series of plume altitude can be translated to volumetric discharge and mass flow rate. For an eruption duration of ∼12 hours, the eruptive volume and mass are estimated at 1.9 km3 and ∼2,900 Tg, respectively, corresponding to a VEI of 5-6 for this event. The high frequency and intensity of lightning was enhanced by the production of fine ash due to magma—seawater interaction with concomitant high charge per unit mass and the high pre-eruptive concentration of dissolved volatiles. Analysis of lightning flash frequencies provides a rapid metric for plume activity and eruption magnitude. Many aspects of this eruption await further investigation by multidisciplinary teams. It represents a golden opportunity for fundamental research regarding the complex, non-linear behavior of high energetic volcanic eruptions and attendant phenomena, with critical implications for hazard mitigation, volcano forecasting, and first-response efforts in future disasters