5,329 research outputs found
Modification of Adhesion and Friction by Surface Structuring
Enhanced and selective adhesion, and controlled friction between contact surfaces are highly desirable mechanical properties for high-level functional materials. There are many instances in nature where such properties have been obtained by design of near-surface architecture. Inspired by many highly functional biological systems, we have explored bio-mimetic materials with different surface patterning, with the goal of designing surfaces that have unique combinations of contact mechanical properties. In the studies presented here, we show how: (a) highly selective adhesion can be achieved by complementarity of patterned charge and shape, and (b) how friction can be modulated by spatial variation in stiffness, and how structured surfaces interact with surface roughness.We consider how adhesion selectivity can be accomplished by complementarity of shape and inter-surface forces. We have studied an example each of charge and shape complementarity for selective adhesion between extended surfaces. First, we studied theoretically how surfaces patterned with stripes of charge interact with each other, and exhibit strong selectivity on rigid surfaces. However, deformability of the surfaces plays a crucial role in modulating adhesion by accommodating mismatches. To achieve shape complementarity, we designed and fabricated patterned elastomeric surfaces with lines of channels and complementary ridges with dimensions at the micrometer scale. We show that such surfaces have highly enhanced effective adhesion for shape complementary pairs and low adhesion between surfaces with a shape mismatch. We find that the pillar/channel combinations form defects to accommodate interfacial misalignment. These defects are interfacial dislocations. Adhesion between complementary surfaces is enhanced by crack trapping and friction, and attenuated due to the energy released by dislocation structures. In addition to enhanced adhesion, we studied the deliberate control of friction through near-surface micro-structures. Friction measurements on elastomeric surfaces patterned with periodic variation in stiffness show that it undergoes an auto-roughening transition under shear and this process can strongly attenuate overall sliding friction. Friction reduction is due to reduction of real contact area, as the initially full contact breaks up into partial contact at the interface. Finite element analysis demonstrates how auto-roughening depends on the modulus mismatch, frictional stress and normal displacement.A surface with random roughness is used to study sliding friction against micro-channel structures under fixed normal force. In contrast to a smooth surface, against which structured surfaces all have highly reduced sliding friction, the roughened surface can exhibit significantly larger frictional force on a structured surface. The enhancement of sliding friction is governed by channel depth, spacing and applied normal force
Robust Correlation Tracking for UAV with Feature Integration and Response Map Enhancement
Recently, correlation filter (CF)-based tracking algorithms have attained extensive interest in the field of unmanned aerial vehicle (UAV) tracking. Nonetheless, existing trackers still struggle with selecting suitable features and alleviating the model drift issue for online UAV tracking. In this paper, a robust CF-based tracker with feature integration and response map enhancement is proposed. Concretely, we develop a novel feature integration method that comprehensively describes the target by leveraging auxiliary gradient information extracted from the binary representation. Subsequently, the integrated features are utilized to learn a background-aware correlation filter (BACF) for generating a response map that implies the target location. To mitigate the risk of model drift, we introduce saliency awareness in the BACF framework and further propose an adaptive response fusion strategy to enhance the discriminating capability of the response map. Moreover, a dynamic model update mechanism is designed to prevent filter contamination and maintain tracking stability. Experiments on three public benchmarks verify that the proposed tracker outperforms several state-of-the-art algorithms and achieves a real-time tracking speed, which can be applied in UAV tracking scenarios efficiently
Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice
<p>Abstract</p> <p>Background</p> <p>Mice lacking the preproenkephalin (<it>ppENK</it>) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in <it>ppENK </it>knock-out (KO) mice appeared to occur in supraspinal response to painful stimuli. However the functional role of enkephalins in the supraspinal nociceptive processing and their underlying mechanism is not clear. The aim of present study was to compare supraspinal nociceptive and morphine antinociceptive responses between WT and <it>ppENK </it>KO mice.</p> <p>Results</p> <p>The genotypes of bred KO mice were confirmed by PCR. Met-enkephalin immunoreactive neurons were labeled in the caudate-putamen, intermediated part of lateral septum, lateral globus pallidus, intermediated part of lateral septum, hypothalamus, and amygdala of WT mice. Met-enkephalin immunoreactive neurons were not found in the same brain areas in KO mice. Tail withdrawal and von Frey test results did not differ between WT and KO mice. KO mice had shorter latency to start paw licking than WT mice in the hot plate test. The maximal percent effect of morphine treatments (5 mg/kg and 10 mg/kg, i.p.) differed between WT and KO mice in hot plate test. The current source density (CSD) profiles evoked by peripheral noxious stimuli in the primary somatosenstory cortex (S1) and anterior cingulate cortex (ACC) were similar in WT and KO mice. After morphine injection, the amplitude of the laser-evoked sink currents was decreased in S1 while the amplitude of electrical-evoked sink currents was increased in the ACC. These differential morphine effects in S1 and ACC were enhanced in KO mice. Facilitation of synaptic currents in the ACC is mediated by GABA inhibitory interneurons in the local circuitry. Percent increases in opioid receptor binding in S1 and ACC were 5.1% and 5.8%, respectively.</p> <p>Conclusion</p> <p>The present results indicate that the endogenous enkephalin system is not involved in acute nociceptive transmission in the spinal cord, S1, and ACC. However, morphine preferentially suppressed supraspinal related nociceptive behavior in KO mice. This effect was reflected in the potentiated differential effects of morphine in the S1 and ACC in KO mice. This potentiation may be due to an up-regulation of opioid receptors. Thus these findings strongly suggest an antagonistic interaction between the endogenous enkephalinergic system and exogenous opioid analgesic actions in the supraspinal brain structures.</p
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