393 research outputs found

    Thermal Lens Spectroscopy and Its Applications

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    Social Media Marketing: Business Value, Multiple Media Interplay and Contingent Effect of Product Popularity

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    This dissertation explores the new phenomenon of social media marketing from a whole marketing channel perspective. First, as managers often find difficulties in quantifying its impact, I attempt to assess the business value of social media marketing at the channel level for a product’s financial success. Second, since social media marketing is a new practice, I investigate its impact and its interplay with other marketing media. Previous studies on relationship between multiple advertising media show mixed results, i.e., they found both substitution and complementarity effects. I propose such relationship between multiple media is contingent on product characteristics such as product popularity. A rich dataset is constructed, which includes information about 200 movies’ Facebook marketing activities, box office revenues, traditional marketing expenditure and various control variables. I estimate that an official Facebook Page contributes to an average increase of more than 6millioninopeningboxofficerevenueandmorethan6 million in opening box office revenue and more than 15 million in overall box office revenue. Additionally, I find because of its low marketing cost (marketer side) and low search cost (consumer side), social media marketing benefits less popular movies through both direct impact of marketing intensity and indirect impact of attenuating substitution for other advertising media. The results will enhance our knowledge of social media marketing at the channel level and suggest implications of Facebook marketing implementation and multiple media advertising coordination for practitioners

    Effect of size, shape, and surface modification on cytotoxicity of gold nanoparticles to human Hep-2 and canine MDCK cells

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    There have been increasing interests in applying gold nanoparticles in biological research, drug delivery, and therapy. As the interaction of gold nanoparticles with cells relies on properties of nanoparticles, the cytotoxicity is complex and still under debating. In this work, we investigate the cytotoxicity of gold nanoparticles of different encapsulations, surface charge states, sizes and shapes to both human HEp-2 and canine MDCK cells. We found that cetyltrimethylammonium-bromide- (CTAB-) encapsulated gold nanorods (GNRs) were relatively higher cytotoxic than GNRs undergone further polymer coating and citrate stabilized gold nanospheres (GNSs). The toxicity of CTAB-encapsulated GNRs was mainly caused by CTAB on GNRs’ surface but not free CTAB in the solution. No obvious difference was found among GNRs of different aspect ratios. Time-lapse study revealed that cell death caused by GNRs occurred predominately within one hour through apoptosis, whereas cell death by free CTAB was in a time- and dose-dependent manner. Both positively and negatively surface-charged polymer-coated GNRs (PSS-GNRs and PAH-PSS-GNRs) showed similar levels of cytotoxic, suggesting the significance of surface functionality rather than surface charge in this case

    Effect of size, shape, and surface modification on cytotoxicity of gold nanoparticles to human Hep-2 and canine MDCK cells

    Get PDF
    There have been increasing interests in applying gold nanoparticles in biological research, drug delivery, and therapy. As the interaction of gold nanoparticles with cells relies on properties of nanoparticles, the cytotoxicity is complex and still under debating. In this work, we investigate the cytotoxicity of gold nanoparticles of different encapsulations, surface charge states, sizes and shapes to both human HEp-2 and canine MDCK cells. We found that cetyltrimethylammonium-bromide- (CTAB-) encapsulated gold nanorods (GNRs) were relatively higher cytotoxic than GNRs undergone further polymer coating and citrate stabilized gold nanospheres (GNSs). The toxicity of CTAB-encapsulated GNRs was mainly caused by CTAB on GNRs’ surface but not free CTAB in the solution. No obvious difference was found among GNRs of different aspect ratios. Time-lapse study revealed that cell death caused by GNRs occurred predominately within one hour through apoptosis, whereas cell death by free CTAB was in a time- and dose-dependent manner. Both positively and negatively surface-charged polymer-coated GNRs (PSS-GNRs and PAH-PSS-GNRs) showed similar levels of cytotoxic, suggesting the significance of surface functionality rather than surface charge in this case

    Effect of size, shape, and surface modification on cytotoxicity of gold nanoparticles to human Hep-2 and canine MDCK cells

    Get PDF
    There have been increasing interests in applying gold nanoparticles in biological research, drug delivery, and therapy. As the interaction of gold nanoparticles with cells relies on properties of nanoparticles, the cytotoxicity is complex and still under debating. In this work, we investigate the cytotoxicity of gold nanoparticles of different encapsulations, surface charge states, sizes and shapes to both human HEp-2 and canine MDCK cells. We found that cetyltrimethylammonium-bromide- (CTAB-) encapsulated gold nanorods (GNRs) were relatively higher cytotoxic than GNRs undergone further polymer coating and citrate stabilized gold nanospheres (GNSs). The toxicity of CTAB-encapsulated GNRs was mainly caused by CTAB on GNRs’ surface but not free CTAB in the solution. No obvious difference was found among GNRs of different aspect ratios. Time-lapse study revealed that cell death caused by GNRs occurred predominately within one hour through apoptosis, whereas cell death by free CTAB was in a time- and dose-dependent manner. Both positively and negatively surface-charged polymer-coated GNRs (PSS-GNRs and PAH-PSS-GNRs) showed similar levels of cytotoxic, suggesting the significance of surface functionality rather than surface charge in this case

    A Unified Subspace Classification Framework Developed for Diagnostic System Using Microwave Signal

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    Subspace learning is widely used in many signal processing and statistical learning problems where the signal is assumably generated from a low dimensional space. In this paper, we present a unified classifier including several concepts from different subspace techniques, such as PCA, LRC, LDA, GLRT, etc. The objective is to project the original signal (usually of high dimension) into a smaller subspace with 1) within-class data structure preserved and 2) between-class-distance enhanced. A novel classification technique called Maximum Angle Subspace Classifier (MASC) is presented to achieve these purposes. To compensate for the computational complexity and non-convexity of MASC, an approximation is proposed as a trade-off between the classification performance and the computational issue. The approaches are applied to the problem of classifying high dimensional frequency measurements from a microwave based diagnostic system and results are compared with existing methods

    A Subspace Learning Algorithm For Microwave Scattering Signal Classification With Application To Wood Quality Assessment

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    A classification algorithm based on a linear subspace model has been developed and is presented in this paper. To further improve the classification results, the full linear subspace of each class is split into subspaces with lower dimensions and characterized by local coordinates constructed from automatically selected training data. The training data selection is implemented by optimizations with least squares constraints or L1 regularization. The working application is to determine the quality in wooden logs using microwave signals [1]. The experimental results are shown and compared with classical method

    Engagement on Digital Platforms: A Theoretical Perspective

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    The new business models enabled by digital platforms and the ecosystems built around them drive the most profound change in the global macroeconomic environment today. User engagement plays a crucial role in value creation for platform business models. Although Information Systems (IS) literature has started examining this key concept, it presents diverse and inconsistent conceptualizations, resulting in an incomplete nomological network of engagement with important antecedents, consequences, and mechanisms left largely unexamined. This study aims to build a theory of engagement for digital platforms. To achieve this goal, we have provided a coherent definition and a preliminary typology in this extended abstract. We will construct a nomological network of engagement in our follow-up study
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