Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

To investigate the bioequivalence and the population pharmacokinetics of cefuroxime lysine and cefuroxime sodium in healthy beagle dogs. A randomized 2-period crossover design in 18 healthy beagle dogs after receiving 20, 40, and 80 mg/kg of cefuroxime lysine or cefuroxime sodium was conducted. A 3-compartment open model was used as the basic model for the population pharmacokinetic study. Both of the antibiotics exhibited dose-proportional pharmacokinetics over the dose range of 20–80 mg/kg. The mean relative bioavailability of cefuroxime lysine versus cefuroxime sodium was 1.05 (range, 0.71 to 1.42), with a significant difference between males and females. The estimates of population pharmacokinetic of CL, V1, Q2, V2, Q3, V3 were 3.74 mL/h, 1.70 mL, 29.5 mL/min, 3.58 mL, 0.31 mL/min, and 158 mL for cefuroxime lysine and 4.10 mL/h, 1.00 mL, 38.5 mL/min, 4.19 mL, 0.06 mL/min, and 13.6 mL for cefuroxime sodium, respectively. The inter-individual variability was determined to be less than 29.1%. A linear pharmacokinetic was revealed for cefuroxime lysine and cefuroxime sodium in dogs after intravenous infusion, and the bioequivalence of these forms of the antibiotic was observed with the significant gender-related differences in mean relative bioavailability of cefuroxime lysine versus cefuroxime sodium

Constraints on Axion-like Particles from the Observation of GRB 221009A by LHAASO

The LHAASO collaboration recently reported the measurement of the gamma-ray spectra of GRB 221009A, which is the brightest burst ever, covering an energy range from 0.3 $\mathrm{TeV}$ to about 10 $\mathrm{TeV}$. Based on the observation, we investigate the ALP-photon oscillation effect in the host galaxy of GRB 221009A and the Milky Way. The ${\rm CL_s}$ method is applied to set constraints on the ALP parameters in this study. Given the uncertain magnetic field configuration in the host galaxy, we use three different models: a homogeneous magnetic field model, a magnetic field model identical to that of the Milky Way, and a model constructed from the HST observations of the host galaxy. We find that the constraints derived using these three host galaxy magnetic field models are comparable. Our results are complementary in the small ALP mass regions compared with other experiments.Comment: 8 pages, 13 figure