Fire Path Fighting in Forest Off-Road Using Improved ACA—An Example of The Northern Primitive Forest Region of The Great Xing’an Range in Inner Mongolia, China

In order to deal with the threat of forest fire to the original forest resources, improve the efficiency of firefighting, and better protect the forest ecological resources in the original forest area. In this paper, the ant colony algorithm is used as the search algorithm for the firefighting path, and the Qiqian Forestry Bureau in the northern primitive forest region of the Great Xing‘an Range in Inner Mongolia is taken as the research object to select road entry points with different linear distances from the fire poin. By adjusting the pheromone volatility coefficient, the improved ant colony algorithm can better deal with the off-road firefighting path planning in forest environment. The simulation results show that using the road entry point with linear distance of 24.5 km as the starting point for the path planning of off-road firefighting in the northern the Great Xing‘an Range can effectively shorten the path and minimize the loss caused by forest fire. At the same time, it verifies the effectiveness and rationality of the path planning of the improved ant colony algorithm under such environmental conditions. The optimization scheme meets the needs of forest fire fighting in the original forest area, and can play a guiding role in design of the forest fire path planning in the original forest area in the northern Great Xing‘an Range of Inner Mongolia and a reference for fire path planning in other forest areas in China

Fire Path Fighting in Forest Off-Road Using Improved ACA—An Example of The Northern Primitive Forest Region of The Great Xing’an Range in Inner Mongolia, China

In order to deal with the threat of forest fire to the original forest resources, improve the efficiency of firefighting, and better protect the forest ecological resources in the original forest area. In this paper, the ant colony algorithm is used as the search algorithm for the firefighting path, and the Qiqian Forestry Bureau in the northern primitive forest region of the Great Xing‘an Range in Inner Mongolia is taken as the research object to select road entry points with different linear distances from the fire poin. By adjusting the pheromone volatility coefficient, the improved ant colony algorithm can better deal with the off-road firefighting path planning in forest environment. The simulation results show that using the road entry point with linear distance of 24.5 km as the starting point for the path planning of off-road firefighting in the northern the Great Xing‘an Range can effectively shorten the path and minimize the loss caused by forest fire. At the same time, it verifies the effectiveness and rationality of the path planning of the improved ant colony algorithm under such environmental conditions. The optimization scheme meets the needs of forest fire fighting in the original forest area, and can play a guiding role in design of the forest fire path planning in the original forest area in the northern Great Xing‘an Range of Inner Mongolia and a reference for fire path planning in other forest areas in China

Research Advances of Prevention and Control of Hydrogen Sulfide in Coal Mines

Sudden emission and casualty accidents caused by abnormal enrichment of hydrogen sulfide (H2S) in coal mines are becoming frequent increasingly, causing major casualties and environmental pollution. Scholars in various countries have developed various measuring devices for hydrogen sulfide content in coal and rock formations and their calculation methods. The existing prevention and control technologies of H2S in coal mines were summarized in various countries. According to the distribution characteristics, occurrence modes, and emission forms of H2S in coal mines, the prevention and control technologies of H2S in coal-bearing strata, airflow in tunnel, and underground water body are mainly introduced. Analyzed the effects of different ventilation systems on prevention and control of H2S, which include conventional ventilation system, partial homotropal ventilation system, and full homotropal ventilation system. The methods used mainly include neutralization by injecting alkalizer through drilling in coal seams with high pressure, spraying alkalizer in tunnel, attenuation by increasing wind amount, changing the ventilation method, pumping, dredging, and blocking the water that contains H2S as well as comprehensive prevention and control method. The basic agents adopted mainly include sodium carbonate (the mass percentage concentration is about 0.5% ~ 3.0%) and sodium bicarbonate solution, and some basic solution is added by an additive, such as surfactant, Fenton reagent, sodium dodecyl benzene sulfonate, sodium hypochlorite, or chloramine-T. The treatment effect and the main problems of each prevention and control technology are analyzed, and a comprehensive method of prevention and control techniques of H2S in coal mines is proposed. According to current technological level as well as the cost, the effective prevention and control techniques of H2S should take the occurrence, distribution, and emission forms of H2S in coal mines as well as the content into consideration

Chemerin Suppresses Ovarian Follicular Development and Its Potential Involvement in Follicular Arrest in Rats treated Chronically with Dihydrotestosterone

In the present study, we have investigated the cellular mechanisms of androgen-induced antral follicular growth arrest and the possible involvement of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) in this process, using a chronically androgenized rat model. We hypothesize that hyperandrogenism induces antral follicle growth arrest via the action of chemerin and ovarian structural changes, resulting from granulosa cell and oocyte apoptosis and theca cell survival. Dihydrotestosterone (DHT) treatment resulted in increased expression of chemerin and CMKLR1 in antral follicles, absence of corpus luteum, and increased atypical follicles. Addition of chemerin to follicle cultures induced granulosa cell apoptosis and suppressed basal, FSH- and growth differentiation factor-9-stimulated follicular growth. DHT down-regulated aromatase expression and increased active caspase-3 content and DNA fragmentation in granulosa cells in vivo. These changes were accompanied by higher phosphatase and tensin homolog and lower phospho-Akt (Ser473) content in antral follicles and higher calpain expression and down-regulation of cytoskeletal proteins in atypical follicles, which were constituted predominantly of theca cells. DHT also activated granulosa cell caspase-3, decreased X-linked inhibitor of apoptosis protein, poly(ADP-ribose) polymerase, and phospho-Akt contents and induced apoptosis in vitro, responses readily attenuated by forced X-linked inhibitor of apoptosis protein expression. These findings are consistent with our hypothesis that antral follicular growth arrest in DHT-treated rats results from increased chemerin expression and action, as well as changes in follicular cell fate and structure, which are a consequence of dysregulated interactions of pro-survival and pro-apoptotic modulators in a cell-specific manner. Our observations suggest that this chronically androgenized rat model may be useful for studies on the long-term effects of androgens on folliculogenesis and may have implications for the female reproductive disorders associated with hyperandrogenism

EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC

Abstract Background The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy. It can decrease MYC expression levels and cause effective anti-tumor effects in diverse human cancers. However, its cytotoxic effect and related mechanisms of drug resistance are poorly understood in hepatocellular carcinomas (HCC). Here, we investigated the anti-tumor effects of BET inhibitor on HCC and the molecular mechanisms involved in its associated drug resistance. Methods We assessed the cytotoxicity of BET inhibitor on HCC cells compared with sorafenib by cell viability assay, metastasis assay and reproduced the anti-tumor effect in xenograft mouse model. In addition, the molecular mechanisms involved in drug resistance on JQ1-resistant HCC cells were revealed by western blotting, qRT-PCR, whole exome-sequencing and gene-editing technology. Finally, with specific inhibition of EGFR or ERK activity by interference RNAs or inhibitors, the efficacy of the synergistic treatment was investigated using cell viability assay, colony formation, apoptosis and xenograft mouse model. Results We found that JQ1, a commonly used BET bromo-domain inhibitor, offered a better anti-tumor response than sorafenib in MYC-positive HCC cells by inducing apoptosis in vitro and in vivo. Unlike sorafenib, JQ1 treatment significantly impaired mitochondrial respiration and glycolysis in HCC cells. Importantly, we revealed that MAPK activation by a previously undescribed activating mutation of EGFR-I645L, was critical for JQ1 sensitivity through stabilizing oncogenic MYC protein in JQ1-resistant HCC cells. Inhibition of either EGFR or ERK activity overcame the JQ1 resistance and significantly decreased MYC protein level in vitro and in vivo. Conclusion Since MYC amplification is frequently identified in HCC, co-occurring with EGFR amplification, our findings suggest that targeting EGFR signaling might be essential for JQ1 therapy in advanced HCC

Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma

Purpose: Metabolic reprogramming is frequently identified in hepatocellular carcinoma (HCC), which is the most common type of liver malignancy. The reprogrammed cellular metabolisms promote tumor cell survival, proliferation, angiogenesis, and metastasis. However, the mechanisms of this process remain unclear in HCC