A Linguistic Analysis of Group Support Systems Interactions for Uncovering Social Realities of Organizations

Language represents the medium through which we encounter reality and can be viewed as a human social action (Holtgraves 2002). In this study, we apply speech act theory to analyze the data collected in a study by Trauth and Jessup (2000) and demonstrate that GSS can be an effective tool for diagnosing the social life of an organization. Our linguistic analysis confirms previous research findings that both the topic and the group size influence the pattern of discussion, especially when issues are threatening. In addition, when GSS is applied to such an issue, linguistic analysis helps to uncover hidden defensive speech routines. Identifying the speech acts of GSS discussions may therefore complement positivist and interpretive analysis by examining if participants’ engagement is superficial or profound, if consensus is reached or blocked, and if certain speech acts lead to dysfunctional organizational learning. Taken together with Trauth and Jessup (2000)’s study, we show that social realities revealed in GSS discussions are multi-dimensional and that, by adopting a different research stance to better understand the role of GSS, a variety of research benefits may be derived

Ferritin level prospectively predicts hepatocarcinogenesis in patients with chronic hepatitis B virus infection

Previous studies have detected a higher level of ferritin in patients with hepatocellular carcinoma (HCC), but a potential causal association between serum ferritin level and hepatocarcinogenesis remains to be clarified. Using a well-established prospective cohort and longitudinally collected serial blood samples, the association between baseline ferritin levels and HCC risk were evaluated in 1,152 patients infected with hepatitis B virus (HBV), a major risk factor for HCC. The association was assessed by Cox proportional hazards regression model using univariate and multivariate analyses and longitudinal analysis. It was demonstrated that HBV patients who developed HCC had a significantly higher baseline ferritin level than those who remained cancer-free (188.00 vs. 108.00 ng/ml, P\u3c0.0001). The patients with a high ferritin level (≥200 ng/ml) had 2.43-fold increased risk of HCC compared to those with lower ferritin levels [hazard ratio (HR), 2.43; 95% confidence interval, 1.63-3.63]. A significant trend of increasing HRs along with elevated ferritin levels was observed (P for trend \u3c0.0001). The association was still significant after multivariate adjustment. Incorporating ferritin into the α-fetoprotein (AFP) model significantly improved the performance of HCC prediction (the area under the curve from 0.74 to 0.77, P=0.003). Longitudinal analysis showed that the average ferritin level in HBV patients who developed HCC was persistently higher than in those who were cancer-free during follow-up. HCC risk reached a peak at approximately the fifth year after baseline ferritin detection. Moreover, stratified analyses showed that the association was noted in both males and females, and was prominent in patients with a low AFP value. In short, serum ferritin level could independently predict the risk of HBV-related HCC and may have a complementary role in AFP-based HCC diagnosis. Future studies are warranted to validate these findings and test its clinical applicability in HCC prevention and management. © 2018, Spandidos Publication