Interpolation function of the genocchi type polynomials

The main purpose of this paper is to construct not only generating functions of the new approach Genocchi type numbers and polynomials but also interpolation function of these numbers and polynomials which are related to a, b, c arbitrary positive real parameters. We prove multiplication theorem of these polynomials. Furthermore, we give some identities and applications associated with these numbers, polynomials and their interpolation functions.Comment: 14 page

Evaluation of chemical composition, antioxidant and anti-acetylcholinesterase activities of Hypericum neurocalycinum and Hypericum malatyanum

This study was conducted to evaluate the chemical composition, antioxidant and anti-acetylcholinesterase (anti-AChE) activities of methanolic extracts of H. neurocalycinum and H. malatyanum, two endemic species of the Turkish flora. HPLC-DAD analysis indicated that two naphthodianthrones (pseudohypericin and hypericin) together with chlorogenic acid, rutin, hyperoside, isoquercitrin, kaempferol, quercitrin, quercetin, amentoflavone and hyperforin are the main compounds present in the methanol extracts. The extracts were tested in vitro for their antioxidant activities including, inhibition of lipid peroxidation in liposomes, induced by Fe3+/ ascorbate system, scavenging effect on DPPH center dot and superoxide anion radicals, and ferric ion reducing antioxidant power (FRAP). H. neurocalycinum demonstrated stronger antioxidant properties than H. malatyanum due to higher activity on scavenging DPPH center dot (EC50 = 2.49 +/- 0.09 mg/mL) and superoxide anion radicals (EC50 = 0.613 +/- 0.05 mg mg/mL), and inhibition of lipid peroxidation (EC50 = 2.49 +/- 0.09 mg/mL). This difference in activity seems to be due to the presence of higher amounts of the antioxidant compounds (flavonoids) such as rutin, quercetin and kaempferol in H. neurocalycinumextract. The antioxidant activities of the extract may be attributed to their reducing capabilities. At 5 mg/mL H. neurocalycinum (FRAP value = 2.39 +/- 0.039 mM Fe2+) and H. malatyanum (FRAP value = 2.23 +/- 0.013 mMFe(2+)) showed high ability to reduce Fe3+ to Fe2+. The extracts were tested also for their in vitro AChE inhibitory activities. H. neurocalycinum inhibited 72.24 +/- 0.39% of AChE activity at a concentration of 5 mg/mL. It was concluded that H. neurocalycinum is more effective AChE inhibitor and antioxidant than H. malatyanum. (c) 2017 SAAB. Published by Elsevier B. V. All rights reserved

<i>In vitro</i> biological effects of <i>Crataegus microphylla</i> C. Koch

189-196Cratageus species are rich in phenols and flavonoids, which are active compounds that possess beneficial effects. This study aimed to identify the antioxidant, antimicrobial, DNA damage protection activities, and the capacities of acetylcholinesterase (AChE), thioredoxin reductase (ThxR), and α-glucosidase inhibition of the methanol extract of Cratageus microphylla. The plant extract inhibited the formation of free radicals in various assay systems, such as 2,-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2'-diphenyl-1-picrylhydrazyl (DPPH), lipid peroxidation (anti-LPO) and ferric reducing antioxidant power (FRAP) assays. According to the findings, the extract inhibited the lipid peroxidation and neutralized stable DPPH, and ABTS cation radicals with EC50 values of 0.766 ± 0.026 mg/mL, 0.207 ± 0.009 mg/mLand 0.756 ± 0.048 mg/mL, respectively. The extract also acted as a reductant as indicated by the FRAP value (2.841 ± 0.096 mM Fe2+), thus exhibiting its potential as an antioxidant. Moderate AChE (4.94 ± 0.29 mg/mL) and α-glucosidase (14.41 ± 0.29 mg/mL) and significant ThxR (EC50= 0.61 ± 0.06 mg/mL) inhibition activities were observed. DNA damage formation in in vitro assays was 51 % at 0.78 µg/mL concentrations. Therefore, C. microphylla can be considered as a good source of antioxidant, antimicrobial, antidiabetic, anticholinesterase, and anticancer agents

Risk factors for infection with colistin-resistant gram-negative microorganisms: a multicenter study

WOS: 000384907900008PubMed ID: 27236394BACKGROUND: Knowing risk factors for colistin resistance is important since colistin is the only remaining choice for the treatment of infections caused by multi-drug resistant microorganisms. OBJECTIVE: Evaluate risk factors associated with infection by colistin-resistant microorganisms. DESIGN: Retrospective study. SETTINGS: Tertiary healthcare centers. PATIENTS AND METHODS: An e-mail including the title and purpose of the study was sent to 1500 infectious disease specialists via a scientific and social web portal named "Infeksiyon Dunyasi (Infection World)". Demographic and clinical data was requested from respondents. MAIN OUTCOME MEASURE(S): Colistin-resistance. RESULTS: Eighteen infectious disease specialists from twelve tertiary care centers responded to the invitation. Data was collected on 165 patients, 56 cases (39.9%) and 109 (66.0%) age-and sex-matched controls. The colistin-resistant microorganisms isolated from cases were 29 Acinetobacter baumannii (51.8%), 18 Pseudomonas aeruginosa (32.1%) and 9 Klebsiella spp. Colistin, carbapenem, and quinolone use in the last three months were risk factors for colistin resistance in the univariate analysis. Previous quinolone use in the last three months (P=.003; RR: 3.2; 95% CI: 1.5-6,7) and previous colistin use in the last three months (P=.001; RR: 3.6; 95% CI: 1.63-7.99) were significant risk factors in the multivariate analysis. CONCLUSION: Clinicians should limit the use of quinolones and remain aware of the possibility of resistance developing during colistin use. LIMITATIONS: The lack of a heteroresistance analysis on the isolates. No data on use of a loading dose or the use of colistin in combination