The progesterone receptor PROGINS polymorphism is not related to oxidative stress factors in women with polycystic ovary syndrome

<p>Abstract</p> <p>Background</p> <p>Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation in progesterone receptor polymorphism with risk of ovarian and breast cancer have concentrated on a variant known as PROGINS.</p> <p>Methods</p> <p>Ninety-five young women with PCOS and 99 healthy control women were included in our study. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin and <it>PROGINS </it>polymorphism genetic study.</p> <p>Results</p> <p>In PROGINS polymorphism results; in both control and the patient groups T1/T1 has been detected in high levels. But for genotype (p = 0.178) and allele (p = 0.555) frequencies both of the groups give similar results. Statistically significant difference has been detected on serum FSH levels for T1/T1 genotype according to T2/T2 genotype.</p> <p>Conclusion</p> <p>No relation has been detected between the inflammatory and oxidative stress factors, and PROGINS polymorphism alleles. This may be because the PCOS patients are young and their BMI means are normal and their CIMT and oxidative stress markers are like healthy women.</p

TOWARDS EXPO 2020

WOS: 00032280270000

Physician Adherence to the SEMT Guidelines for the Management of Type 2 Diabetes in Turkey: ADMIRE Study

Objective: To evaluate the impact of physicians' adherence to the guidelines developed by the Diabetes Study Group of The Society of Endocrinology and Metabolism of Turkey (SEMT) on glycemic control in diabetes mellitus

A patient-based study on the adherence of physicians to guidelines for the management of type 2 diabetes in Turkey

WOS: 000311026100015PubMed ID: 22652276Aims: To evaluate physicians' adherence to guidelines by Diabetes Study Group of The Society of Endocrinology and Metabolism of Turkey (SEMT). Methods: The medical records of 1790 patients with type 2 diabetes (mean age, 58.7 +/- 10.9 years; diabetes duration, 7.7 perpendicular to 7.5 years) followed by 180 physicians during last 12 months were reviewed. Adherence to SEMT guidelines was analysed under medical history, physical examination and laboratory evaluations subheadings, each scored on a 10-point scale. Effects of patients' age, gender, diabetes duration, body mass index, chronic complications, physicians' specialty and institution on guideline adherence were evaluated. Results: Follow-up procedures were >75% compliant for 52% of patients. Full adherence to medical history, physical examination and laboratory aspects of SEMT guidelines were met in 68.6%, 8.3% and 19.2% of patients, respectively. Older patients and males fared better for laboratory evaluations. All aspects of guideline adherence were poor in patients with short duration of diabetes and in the absence of chronic complications. State institutions and family practitioners had lower adherence scores for physical examination and laboratory evaluation. Conclusions: Overall guideline adherence of physicians was suboptimal. Educational programs emphasizing the preventive aspect of diabetes management, targeted towards family practitioners and state institutions, may improve guideline adherence and patient outcome. (C) 2012 Elsevier Ireland Ltd. All rights reserved.sanofi TurkeySanofi-AventisWe thank to the members of the ADMIRE Study Group for their valuable contribution (see Appendix). We thank to Oktay Ozdemir and Murat Kirtis for their assistance with statistical analysis and drafting the manuscript. We also thank to sanofi Turkey for providing unrestricted and unconditioned grant for the study