6 research outputs found
Using a Process Dissociation Approach to Assess Verbal Short-Term Memory for Item and Order Information in a Sample of Individuals with a Self-Reported Diagnosis of Dyslexia
Get PDFPrevious studies have examined whether difficulties in short-term memory for verbal information, that might be associated with dyslexia, are driven by problems in retaining either information about to-be-remembered items or the order in which these items were presented. However, such studies have not used process-pure measures of short-term memory for item or order information. In this work we adapt a process dissociation procedure to properly distinguish the contributions of item and order processes to verbal short-term memory in a group of 28 adults with a self-reported diagnosis of dyslexia and a comparison sample of 29 adults without a dyslexia diagnosis. In contrast to previous work that has suggested that individuals with dyslexia experience item deficits resulting from inefficient phonological representation and language-independent order memory deficits, the results showed no evidence of specific problems in short-term retention of either item or order information among the individuals with a self-reported diagnosis of dyslexia, despite this group showing expected difficulties on separate measures of word and non-word reading. However, there was some suggestive evidence of a link between order memory for verbal material and individual differences in non-word reading, consistent with other claims for a role of order memory in phonologically mediated reading. The data from the current study therefore provide empirical evidence to question the extent to which item and order short-term memory are necessarily impaired in dyslexia
Spatial Structure and Corridor Construction of Intangible Cultural Heritage: A Case Study of the Ming Great Wall
No full textExploring the spatial structure of intangible cultural heritage (ICH) and constructing heritage corridors are conducive to the adaptive reuse of heritage and the improvement of the surviving environment, which is of great significance to the living inheritance of ICH. Guided by the concept of the heritage corridor, this study took the ICH along the Ming Great Wall as the research object. Kernel density estimation and a standard deviation ellipse analysis were used to explore the spatial structure and then combined with a suitability analysis of heritage corridors to further explore the spatial locations of corridors. A multifactor spatial superposition was carried out with the minimal cumulative resistance (MCR) method. The resistance factors, including land use type, elevation, slope, road system, river system, and the heritage corridors, were constructed. The results show that: (1) ICH along the Ming Great Wall forms a spatial pattern of “three cores and one belt”. The high-density core areas exist in Beijing and Liaoning, and the secondary core areas exist in northern Ningxia and southwestern Inner Mongolia. This results from the joint action of the natural, economic, and social environment. (2) On the whole, all kinds of ICH are distributed from southwest to northeast, among which folk art is particularly obvious. (3) The distribution trend of suitability is “high in the east and low in the west”. The high-suitability areas are mainly concentrated in the Beijing-Tianjin-Hebei and Liaoning regions, while the low-suitability areas are concentrated in Gansu, Ningxia, and northern Inner Mongolia. Finally, this study discusses the appropriate development mode of the heritage corridors of the Ming Great Wall from the macrolevel to the mesolevel
Spatial Structure and Corridor Construction of Intangible Cultural Heritage: A Case Study of the Ming Great Wall
No full textExploring the spatial structure of intangible cultural heritage (ICH) and constructing heritage corridors are conducive to the adaptive reuse of heritage and the improvement of the surviving environment, which is of great significance to the living inheritance of ICH. Guided by the concept of the heritage corridor, this study took the ICH along the Ming Great Wall as the research object. Kernel density estimation and a standard deviation ellipse analysis were used to explore the spatial structure and then combined with a suitability analysis of heritage corridors to further explore the spatial locations of corridors. A multifactor spatial superposition was carried out with the minimal cumulative resistance (MCR) method. The resistance factors, including land use type, elevation, slope, road system, river system, and the heritage corridors, were constructed. The results show that: (1) ICH along the Ming Great Wall forms a spatial pattern of “three cores and one belt”. The high-density core areas exist in Beijing and Liaoning, and the secondary core areas exist in northern Ningxia and southwestern Inner Mongolia. This results from the joint action of the natural, economic, and social environment. (2) On the whole, all kinds of ICH are distributed from southwest to northeast, among which folk art is particularly obvious. (3) The distribution trend of suitability is “high in the east and low in the west”. The high-suitability areas are mainly concentrated in the Beijing-Tianjin-Hebei and Liaoning regions, while the low-suitability areas are concentrated in Gansu, Ningxia, and northern Inner Mongolia. Finally, this study discusses the appropriate development mode of the heritage corridors of the Ming Great Wall from the macrolevel to the mesolevel
One New Phenolic Compound from <i>Castanea mollissima</i> Shells and its Suppression of HepatomaCell Proliferation and Inflammation by Inhibiting NF-ÎşB Pathway
No full textShells of Castanea mollissima (CMS), an agricultural remain and often considered waste from chestnut processing industry, have been proven a resource for traditional Chinese medicine. One new phenol, named castanolB(1), andsix known phenolic compounds (2⁻7) were isolated froma water-soluble extract of CMS. Their chemical structures were determined using preparative HPLC and various spectral analyses, and then were compared to literatures, which indicated the first identification of the seven compounds from C. mollissima. The physicochemical property of compound (2) was also reported for the first time. After antiproliferative screening of compounds (1⁻7) on LPS-induced SMMC-7721 and HepG2 hepatoma cells, castanolB (1) showed the best suppression. CastanolB(1) also significantly induced cell apoptosis. Furthermore, castanolB (1) decreasedsecretion of TNF-α and IL-6. Mechanistically, TLR4⁻NF-κB pathway was inhibited bycastanolB (1) with downregulation of TLR4, IKKβ, and NF-κB p65. This study presents a new phenol and shows its profiles of anticancer and anti-inflammation via inhibiting the TLR4⁻NF-κB pathway
