Analyzing covariate clustering effects in healthcare cost subgroups: insights and applications for prediction

Healthcare cost prediction is a challenging task due to the high-dimensionality and high correlation among covariates. Additionally, the skewed, heavy-tailed, and often multi-modal nature of cost data can complicate matters further due to unobserved heterogeneity. In this study, we propose a novel framework for finite mixture regression models that incorporates covariate clustering methods to better account for the effects of clustered covariates on subgroups of the outcome, which enables a more accurate characterization of the complex distribution of the data. The proposed framework can be formulated as a convex optimization problem with an additional penalty term based on the prior similarity of the covariates. To efficiently solve this optimization problem, a specialized EM-ADMM algorithm is proposed that integrates the alternating direction multiplicative method (ADMM) into the iterative process of the expectation-maximizing (EM) algorithm. The convergence of the algorithm and the efficiency of the covariate clustering method are verified using simulation data, and the superiority of the approach over traditional regression techniques is demonstrated using two real Chinese medical expenditure datasets. Our empirical results provide valuable insights into the complex network graph of the covariates and can inform business practices, such as the design and pricing of medical insurance products.Comment: 36 pages; 7 figure

Quantifying chemical short-range order in metallic alloys

Metallic alloys often form phases - known as solid solutions - in which chemical elements are spread out on the same crystal lattice in an almost random manner. The tendency of certain chemical motifs to be more common than others is known as chemical short-range order (SRO) and it has received substantial consideration in alloys with multiple chemical elements present in large concentrations due to their extreme configurational complexity (e.g., high-entropy alloys). Short-range order renders solid solutions "slightly less random than completely random", which is a physically intuitive picture, but not easily quantifiable due to the sheer number of possible chemical motifs and their subtle spatial distribution on the lattice. Here we present a multiscale method to predict and quantify the SRO state of an alloy with atomic resolution, incorporating machine learning techniques to bridge the gap between electronic-structure calculations and the characteristic length scale of SRO. The result is an approach capable of predicting SRO length scale in agreement with experimental measurements while comprehensively correlating SRO with fundamental quantities such as local lattice distortions. This work advances the quantitative understanding of solid-solution phases, paving the way for SRO rigorous incorporation into predictive mechanical and thermodynamic models.Comment: 8 pages, 4 figure

A Fine-Grained Image Description Generation Method Based on Joint Objectives

The goal of fine-grained image description generation techniques is to learn detailed information from images and simulate human-like descriptions that provide coherent and comprehensive textual details about the image content. Currently, most of these methods face two main challenges: description repetition and omission. Moreover, the existing evaluation metrics cannot clearly reflect the performance of models on these two issues. To address these challenges, we propose an innovative Fine-grained Image Description Generation model based on Joint Objectives. Furthermore, we introduce new object-based evaluation metrics to more intuitively assess the model's performance in handling description repetition and omission. This novel approach combines visual features at both the image level and object level to maximize their advantages and incorporates an object penalty mechanism to reduce description repetition. Experimental results demonstrate that our proposed method significantly improves the CIDEr evaluation metric, indicating its excellent performance in addressing description repetition and omission issues

Stress Hyperglycemia: A Problem that Cannot be Ignored

Stress hyperglycemia is a strong neuroendocrine reaction in thehypothalamic pituitary adrenal cortex under severe infection, trauma, burns,hemorrhage, surgery and other harmful stimulated, resulting in increasedsecretion of counter-regulatory hormones. These hormones promotedthe production of sugar and cause glucose metabolism disorders withcytokines and insulin resistance. In this condition, the production of sugarexceeds the utilization of sugar by the tissues, which eventually leads to anincrease in blood glucose levels in plasma. In the intensive care unit, stresshyperglycemia is very common and can occur in patients with or withoutdiabetes. The incidence is as high as 96%, and it is an independent factorin the death of critically ill patients. Hyperglycemia not only prolongsthe hospitalization time, mechanical ventilation time and increased theincidence of serious infections in critically ill patients, but can also leadto the occurrence of type 2 diabetes. Therefore, it is very important tolearn the pathological mechanism of stress hyperglycemia, the harm ofhyperglycemia and blood sugar management