ExpCLIP: Bridging Text and Facial Expressions via Semantic Alignment

The objective of stylized speech-driven facial animation is to create animations that encapsulate specific emotional expressions. Existing methods often depend on pre-established emotional labels or facial expression templates, which may limit the necessary flexibility for accurately conveying user intent. In this research, we introduce a technique that enables the control of arbitrary styles by leveraging natural language as emotion prompts. This technique presents benefits in terms of both flexibility and user-friendliness. To realize this objective, we initially construct a Text-Expression Alignment Dataset (TEAD), wherein each facial expression is paired with several prompt-like descriptions.We propose an innovative automatic annotation method, supported by Large Language Models (LLMs), to expedite the dataset construction, thereby eliminating the substantial expense of manual annotation. Following this, we utilize TEAD to train a CLIP-based model, termed ExpCLIP, which encodes text and facial expressions into semantically aligned style embeddings. The embeddings are subsequently integrated into the facial animation generator to yield expressive and controllable facial animations. Given the limited diversity of facial emotions in existing speech-driven facial animation training data, we further introduce an effective Expression Prompt Augmentation (EPA) mechanism to enable the animation generator to support unprecedented richness in style control. Comprehensive experiments illustrate that our method accomplishes expressive facial animation generation and offers enhanced flexibility in effectively conveying the desired style

Model predictive control strategy in waked wind farms for optimal fatigue loads

With the rapid growth of wind power penetration, wind farms (WFs) are required to implement frequency regulation that active power control to track a given power reference. Due to the wake interaction of the wind turbines (WTs), there is more than one solution to distributing power reference among the operating WTs, which can be exploited as an optimization problem for the second goal, such as fatigue load alleviation. In this paper, a closed-loop model predictive controller is developed that minimizes the wind farm tracking errors, the dynamical fatigue load, and and the load equalization. The controller is evaluated in a mediumfidelity model. A 64 WTs simulation case study is used to demonstrate the control performance for different penalty factor settings. The results indicated the WF can alleviate dynamical fatigue load and have no significant impact on power tracking. However, the uneven load distribution in the wind turbine system poses challenges for maintenance. By adding a trade-off between the load equalization and dynamical fatigue load, the load differences between WTs are significantly reduced, while the dynamical fatigue load slightly increases when selecting a proper penalty factor.Comment: Accepted by Electric Power Systems Researc

Linewidth of single photon transitions in Mn12_{12}-acetate

We use time-domain terahertz spectroscopy to measure the position and linewidth of single photon transitions in Mn$_{12}$-acetate. This linewidth is compared to the linewidth measured in tunneling experiments. We conclude that local magnetic fields (due to dipole or hyperfine interactions) cannot be responsible for the observed linewidth, and suggest that the linewidth is due to variations in the anisotropy constants for different clusters. We also calculate a lower limit on the dipole field distribution that would be expected due to random orientations of clusters and find that collective effects must narrow this distribution in tunneling measurements.Comment: 5 pages, accepted to Physical Review

Low temperature magnetic hysteresis in Mn12_{12} acetate single crystals

Precise magnetic hysteresis measurements of small single crystals of Mn$_{12}$ acetate of spin 10 have been conducted down to 0.4 K using a high sensitivity Hall magnetometer. At higher temperature (>1.6K) step-like changes in magnetization are observed at regularly spaced magnetic field intervals, as previously reported. However, on lowering the temperature the steps in magnetization shift to higher magnetic fields, initially gradually. These results are consistent with the presence of a second order uniaxial magnetic anisotropy, first observed by EPR spectroscopy, and thermally assisted tunnelling with tunnelling relaxation occurring from levels of progressively lower energy as the temperature is reduced. At lower temperature an abrupt shift in step positions is found. We suggest that this shift may be the first evidence of an abrupt, or first-order, transition between thermally assisted and pure quantum tunnelling, suggested by recent theory.Comment: 8 pages, 4 figures, submitted to Europhys. Let

A novel liposomal S-propargyl-cysteine: a sustained release of hydrogen sulfide reducing myocardial fibrosis via TGF-β1/Smad pathway

Purpose: S-propargyl-cysteine (SPRC; alternatively known as ZYZ-802) is a novel modulator of endogenous tissue H2S concentrations with known cardioprotective and anti-inflammatory effects. However, its rapid metabolism and excretion have limited its clinical application. To overcome these issues, we have developed some novel liposomal carriers to deliver ZYZ-802 to cells and tissues and have characterized their physicochemical, morphological and pharmacological properties. Methods :Two liposomal formulations of ZYZ-802 were prepared by thin-layer hydration and the morphological characteristics of each liposome system were assessed using a laser particle size analyzer and transmission electron microscopy. The entrapment efficiency and ZYZ-802 release profiles were determined following ultrafiltration centrifugation, dialysis tube and HPLC measurements. LC-MS/MS was used to evaluate the pharmacokinetic parameters and tissue distribution profiles of each formulation via the measurements of plasma and tissues ZYZ-802 and H2S concentrations. Using an in vivo model of heart failure (HF), the cardio-protective effects of liposomal carrier were determined by echocardiography, histopathology, western blot and the assessment of antioxidant and myocardial fibrosis markers.Results: Both liposomal formulations improved ZYZ-802 pharmacokinetics and optimized H2S concentrations in plasma and tissues. Liposomal ZYZ-802 showed enhanced cardioprotective effects in vivo. Importantly, liposomal ZYZ-802 could inhibit myocardial fibrosis via the inhibition of the TGF-β1/Smad signaling pathway. Conclusion: The liposomal formulations of ZYZ-802 have enhanced pharmacokinetic and pharmacological properties in vivo. This work is the first report to describe the development of liposomal formulations to improve the sustained release of H2S within tissues.Key word: Liposome; S-Propargyl-cysteine (SPRC, ZYZ-802); Hydrogen sulfide; Heart failure; Myocardial fibrosis; TGF-β1/Smad pathwa