4,872 research outputs found
Oxidation of triethylene glycol and tetraethylene glycol by ditelluratocuprate(III) in alkaline medium - A kinetic and mechanistic study
The kinetics of oxidation of triethylene glycol (TEG) and tetraethylene glycol (TTEG) by ditelluratocuprate(III) (DTC) in alkaline liquids were investigated spectrophotometrically in the temperature range of 20oC to 40oC. It was found that the reaction followed pseudo-first order in DTC and less than unit order in reductants. The rate constant kobs of pseudo-first order reaction decreased with an increase of [TeO42-], whereas adding [OH-] enhanced the constant. In addition, there was a negative salt effect. A suitable assumption involving pre-equilibriums before the rate controlling step and a free radical mechanism was proposed from the kinetics study. The rate equations derived from mechanism can explain all experimental phenomena. Moreover, the activation parameters at 298.2K and rate constants of the rate-determining step were evaluated
Detection of the third and fourth heart sounds using Hilbert-Huang transform
<p>Abstract</p> <p>Background</p> <p>The third and fourth heart sound (S3 and S4) are two abnormal heart sound components which are proved to be indicators of heart failure during diastolic period. The combination of using diastolic heart sounds with the standard ECG as a measurement of ventricular dysfunction may improve the noninvasive diagnosis and early detection of myocardial ischemia.</p> <p>Methods</p> <p>In this paper, an adaptive method based on time-frequency analysis is proposed to detect the presence of S3 and S4. Heart sound signals during diastolic periods were analyzed with Hilbert-Huang Transform (HHT). A discrete plot of maximal instantaneous frequency and its amplitude was generated and clustered. S3 and S4 were recognized by the clustered points, and performance of the method was further enhanced by period definition and iteration tracking.</p> <p>Results</p> <p>Using the proposed method, S3 and S4 could be detected adaptively in a same method. 90.3% of heart sound cycles with S3 were detected using our method, 9.6% were missed, and 9.6% were false positive. 94% of S4 were detected using our method, 5.5% were missed, and 16% were false positive.</p> <p>Conclusions</p> <p>The proposed method is adaptive for detecting low-amplitude and low-frequency S3 and S4 simultaneously compared with previous detection methods, which would be practical in primary care.</p
CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization
Low-dose computed tomography (CT) images suffer from noise and artifacts due
to photon starvation and electronic noise. Recently, some works have attempted
to use diffusion models to address the over-smoothness and training instability
encountered by previous deep-learning-based denoising models. However,
diffusion models suffer from long inference times due to the large number of
sampling steps involved. Very recently, cold diffusion model generalizes
classical diffusion models and has greater flexibility. Inspired by the cold
diffusion, this paper presents a novel COntextual eRror-modulated gEneralized
Diffusion model for low-dose CT (LDCT) denoising, termed CoreDiff. First,
CoreDiff utilizes LDCT images to displace the random Gaussian noise and employs
a novel mean-preserving degradation operator to mimic the physical process of
CT degradation, significantly reducing sampling steps thanks to the informative
LDCT images as the starting point of the sampling process. Second, to alleviate
the error accumulation problem caused by the imperfect restoration operator in
the sampling process, we propose a novel ContextuaL Error-modulAted Restoration
Network (CLEAR-Net), which can leverage contextual information to constrain the
sampling process from structural distortion and modulate time step embedding
features for better alignment with the input at the next time step. Third, to
rapidly generalize to a new, unseen dose level with as few resources as
possible, we devise a one-shot learning framework to make CoreDiff generalize
faster and better using only a single LDCT image (un)paired with NDCT.
Extensive experimental results on two datasets demonstrate that our CoreDiff
outperforms competing methods in denoising and generalization performance, with
a clinically acceptable inference time. Source code is made available at
https://github.com/qgao21/CoreDiff.Comment: IEEE Transactions on Medical Imaging, 202
Disrupting the Interaction between Retinoblastoma Protein and Raf-1 Leads to Defects in Progenitor Cell Proliferation and Survival during Early Inner Ear Development
The retinoblastoma protein (pRb) is required for cell-cycle exit of embryonic mammalian hair cells but is not required for hair cell fate determination and early differentiation, and this provides a strategy for hair cell regeneration by manipulating the pRb pathway. To reveal the mechanism of pRb functional modification in the inner ear, we compared the effects of attenuated pRb phosphorylation by an inhibitor of the Mitogen-Activated Protein (MAP) kinase pathway and an inhibitor of the RbâRaf-1 interaction on cultured chicken otocysts. We demonstrated that the activity of pRb is correlated with its phosphorylation state, which is regulated by a newly established cell cycle-independent pathway mediated by the physical interaction between Raf-1 and pRb. The phosphorylation of pRb plays an important role during the early stage of inner ear development, and attenuated phosphorylation in progenitor cells leads to cell cycle arrest and increased apoptosis along with a global down-regulation of the genes involved in cell cycle progression. Our study provides novel routes to modulate pRb function for hair cell regeneration
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