Global Infectious Diseases in September 2022: Monthly Analysis

The threat of infectious diseases caused by pathogenic microorganisms to both human health and the economy is enormous. Coronavirus Disease 2019 (COVID-19) remains a global pandemic. In contrast to many other infectious diseases, monkeypox spreads rapidly and cannot be ignored. Collection of data on contagious diseases can provide quantitative evidence to support effective pandemic control strategies. Global data on predominant infectious diseases collected in the past several weeks and a summary of their epidemiology are presented herein

Global Infectious Diseases in December 2022: Monthly Analysis

The emergence and reoccurrence of infectious diseases constitute a significant threat to human health. Data for this paper were mainly obtained from official websites, such as the WHO and national CDC websites. The report summarizes and analyzes information on infectious diseases for early outbreak monitoring from 24 November to 23 December 2022. Monkeypox cases declined in December 2022 with few deaths, while cholera infections have increased in African regions and war-torn countries. Most sub-Saharan countries are affected by insect-borne diseases, such as dengue, Lassa, and chikungunya fever

Global Infectious Diseases in October 2022: Monthly Analysis

Infectious diseases continue to pose a major threat to worldwide public health. Infections by Coronavirus Disease 2019 have eased but continue to negatively affect international economic development. The situation of other infectious diseases, such as monkeypox and mosquito-borne diseases, became stable in October. Monitoring epidemic situation of infectious diseases can provide rapid insight into global transmission trends and assist in predicting epidemic situations. Visualizations and analyses summarizing the past few weeks of global data on major infectious diseases are provided

Global Infectious Diseases in February 2023: Monthly Analysis

Public health security in human societies is placed under enormous strain by infectious disease epidemics. According to the WHO, COVID-19 and Mpox remain on the list of PHEICs, whereas cholera, dengue, and other contagious diseases remain endemic in several countries and regions. Data on prevalent infectious diseases have been collected worldwide in recent weeks, and may provide new ideas for international collaboration in public health

Global Infectious Diseases in August 2023: A Monthly Analysis

Infectious diseases frequently affect children and adults worldwide. Owing to their specific biology and mode of transmission, the presence of infected individuals or carriers in a region often leads to outbreaks of the disease in that region, and in severe cases, to the death of the infected individual. Infectious diseases have been one of the main causes of mass disability or death in humans for centuries. Surveillance of infectious diseases on a continental scale is therefore important for assessing, recognizing, and preventing the risks that these diseases may pose to animal and human health on a global scale. This report focuses on global infectious disease outbreaks and systematically summarises the timing and location of outbreaks in infected populations between 24 July and 23 August 2023 based on the Global Outbreak Information Surveillance System (GOSIS) of Shusi Technologies

Global Infectious Diseases in June 2023: Monthly Analysis

Infectious diseases are a class of diseases caused by various pathogens that can be transmitted between humans and animals or between humans and animals, thus seriously affecting the development of human society. To control the spread of infectious diseases worldwide and ensure the safety of people’s lives, it is essential to regularly analyze global infectious disease cases. This review is based on data from the World Health Organization, the Centers for Disease Control in countries around the world, Outbreak News Today and many other epidemiological websites to predict the global infectious disease outbreak trend. In addition, using the Shuci Technology global epidemic information monitoring system, we analyzed the distribution of infectious diseases that occurred around the world from 24 May 2023 to 23 June 2023

Global Infectious Diseases in March 2023: Monthly Analysis

Infectious diseases pose a major burden on public health and economic stability among societies worldwide. For centuries, they have been among the leading causes of death and disability, and are currently presenting growing challenges to health security and human progress. This report focuses on global outbreaks of infectious diseases, relying on Shusi Tech’s Global Epidemic Information Monitoring System to systematically summarize outbreak timing and location in infected populations from February 24, 2023, to March 23, 2023. Therefore, surveillance of infectious diseases on a continental scale is important to assess, recognize and protect against the risks that these diseases may pose to animal, domestic animal and human health on a global scale

Global Infectious Diseases in November 2022: Monthly Analysis

Infectious diseases, such as COVID-19 and monkeypox, pose a severe threat to economic development in all countries, as well as to the health of people everywhere. The World Health Organization and National Health Council epidemiological websites were used herein as data sources. Shusi Tech’s Global Epidemic Information Monitoring System was used to analyze the data for infectious diseases, determine changes in global epidemics, determine the distribution and quantity of infectious disease cases from October 24, 2022 to November 23, 2022, and analyze their changing trends. Furthermore, the analysis of these data can be used to predict prevalence rates, and assess epidemic prevention and control measures

Global Infectious Diseases in January 2023: Monthly Analysis

Infectious diseases are a major threat to global health and the economic stability of societies worldwide. To prevent outbreaks, monitoring the growth trends of infectious diseases appears to be particularly important and necessary. Herein, data from epidemiological websites, such as the World Health Organization and National Health Council are used to illustrate the outbreak trends for infectious diseases worldwide. In the context of the COVID-19 pandemic, a global resurgence in other infectious diseases has been observed, particularly influenza in the United States. Proper surveillance and effective strategies are urgently required to keep emerging infectious diseases under control

Identification and validation of hub genes in drug induced acute kidney injury basing on integrated transcriptomic analysis

BackgroundDrug-induced acute kidney damage (DI-AKI) is a clinical phenomenon of rapid loss of kidney function over a brief period of time as a consequence of the using of medicines. The lack of a specialized treatment and the instability of traditional kidney injury markers to detect DI-AKI frequently result in the development of chronic kidney disease. Thus, it is crucial to continue screening for DI-AKI hub genes and specific biomarkers.MethodsDifferentially expressed genes (DEGs) of group iohexol, cisplatin, and vancomycin’s were analyzed using Limma package, and the intersection was calculated. DEGs were then put into String database to create a network of protein-protein interactions (PPI). Ten algorithms are used in the Cytohubba plugin to find the common hub genes. Three DI-AKI models’ hub gene expression was verified in vivo and in vitro using PCR and western blot. To investigate the hub gene’s potential as a biomarker, protein levels of mouse serum and urine were measured by ELISA kits. The UUO, IRI and aristolochic acid I-induced nephrotoxicity (AAN) datasets in the GEO database were utilized for external data verification by WGCNA and Limma package. Finally, the Elisa kit was used to identify DI-AKI patient samples.Results95 up-regulated common DEGs and 32 down-regulated common DEGs were obtained using Limma package. A PPI network with 84 nodes and 24 edges was built with confidence >0.4. Four hub genes were obtained by Algorithms of Cytohubba plugin, including TLR4, AOC3, IRF4 and TNFAIP6. Then, we discovered that the protein and mRNA levels of four hub genes were significantly changed in the DI-AKI model in vivo and in vitro. External data validation revealed that only the AAN model, which also belonged to DI-AKI model, had significant difference in these hub genes, whereas IRI and UUO did not. Finally, we found that plasma TLR4 levels were higher in patients with DI-AKI, especially in vancomycin-induced AKI.ConclusionThe immune system and inflammation are key factors in DI-AKI. We discovered the immunological and inflammatory-related genes TLR4, AOC3, IRF4, and TNFAIP6, which may be promising specific biomarkers and essential hub genes for the prevention and identification of DI-AKI