A search for energy-dependence of the Kes 73/1E 1841-045 morphology in GeV

While the Kes 73/1E 1841-045 system had been confirmed as an extended GeV source, whether its morphology depends on the photon energy or not deserves our further investigation. Adopting data collected by Fermi Large Area Telescope (LAT) again, we look into the extensions of this source in three energy bands individually: 0.3-1 GeV, 1-3 GeV and 3-200 GeV. We find that the 0.3-1 GeV morphology is point-like and is quite different from those in the other two bands, although we cannot robustly reject a unified morphology for the whole LAT band.Comment: Approved for publication in PoS as a proceeding of the 7th International Fermi Symposium (IFS2017

Fermi Large Area Telescope Observations of the Fast-dimming Crab Nebula in 60-600 MeV

Context: The Crab pulsar and its nebula are the origin of relativistic electrons which can be observed through their synchrotron and inverse Compton emission. The transition between synchrotron-dominated and inverse-Compton-dominated emissions takes place at $\approx 10^9$ eV. Aims: The short-term (weeks to months) flux variability of the synchrotron emission from the most energetic electrons is investigated with data from ten years of observations with the Fermi Large Area Telescope (LAT) in the energy range from 60 MeV to 600 MeV. Methods: The off-pulse light-curve has been reconstructed from phase-resolved data. The corresponding histogram of flux measurements is used to identify distributions of flux-states and the statistical significance of a lower-flux component is estimated with dedicated simulations of mock light-curves. The energy spectra for different flux states are reconstructed. Results: We confirm the presence of flaring-states which follow a log-normal flux distribution. Additionally, we discover a low-flux state where the flux drops to as low as 18.4% of the intermediate-state average flux and stays there for several weeks. The transition time is observed to be as short as 2 days. The energy spectrum during the low-flux state resembles the extrapolation of the inverse-Compton spectrum measured at energies beyond several GeV energy, implying that the high-energy part of the synchrotron emission is dramatically depressed. Conclusions: The low-flux state found here and the transition time of at most 10 days indicate that the bulk ($>75$%) of the synchrotron emission above $10^8$ eV originates in a compact volume with apparent angular size of $\theta\approx0.4" t_\mathrm{var}/(5 \mathrm{d})$. We tentatively infer that the so-called inner knot feature is the origin of the bulk of the $\gamma$-ray emission.Comment: Accepted by A&A on 05.05.2020; Original version submitted on 19.09.201

Inferring the origins of the pulsed gamma-ray emission from the Crab pulsar with 10-year Fermi LAT data

Context: The Crab pulsar is a bright $\gamma$-ray source detected at photon energies up to $\sim$1 TeV. Its phase-averaged and phase-resolved $\gamma$-ray spectra below 10 GeV exhibit exponential cutoffs while those above 10 GeV apparently follow simple power-laws. Aims: We re-visit the $\gamma$-ray properties of the Crab pulsar with 10-year \emph{Fermi} Large Area Telescope (LAT) data in the range of 60 MeV--500 GeV. With the phase-resolved spectra, we investigate the origins and mechanisms responsible for the emissions. Methods: The phaseograms are reconstructed for different energy bands and further analysed using a wavelet decomposition. The phase-resolved energy spectra are combined with the observations of ground-based instruments like MAGIC and VERITAS to achieve a larger energy converage. We fit power-law models to the overlapping energy spectra from 10 GeV to $\sim$1 TeV. We include in the fit a relative cross-calibration of energy scales between air-shower based gamma-ray telescopes with the orbital pair-production telescope of the Fermi mission. Results: We confirm the energy-dependence of the $\gamma$-ray pulse shape, and equivalently, the phase-dependence of the spectral shape for the Crab pulsar. A relatively sharp cutoff at a relatively high energy of $\sim$8 GeV is observed for the bridge-phase emission. The $E>$10 GeV spectrum observed for the second pulse peak is harder than those for other phases. Conclusions: In view of the diversity of phase-resolved spectral shapes of the Crab pulsar, we tentatively propose a multi-origin scenario where the polar-cap, outer-gap and relativistic-wind regions are involved.Comment: Original article published in A&A on 10.08.2020; Data values available at CDS via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/640/A43 ; Erratum (at the back) accepted by A&A on 10.03.2021; Sincere gratitude is given to D. Horns for his encouragement regarding my submission as a single autho

Rotationally-Driven Fragmentation for the Formation of the Binary Protostellar System L1551 IRS 5

Either bulk rotation or local turbulence is widely invoked to drive fragmentation in collapsing cores so as to produce multiple star systems. Even when the two mechanisms predict different manners in which the stellar spins and orbits are aligned, subsequent internal or external interactions can drive multiple systems towards or away from alignment thus masking their formation process. Here, we demonstrate that the geometrical and dynamical relationship between the binary system and its surrounding bulk envelope provide the crucial distinction between fragmentation models. We find that the circumstellar disks of the binary protostellar system L1551 IRS 5 are closely parallel not just with each other but also with their surrounding flattened envelope. Measurements of the relative proper motion of the binary components spanning nearly 30 yr indicate an orbital motion in the same sense as the envelope rotation. Eliminating orbital solutions whereby the circumstellar disks would be tidally truncated to sizes smaller than are observed, the remaining solutions favor a circular or low-eccentricity orbit tilted by up to $\sim$25$^\circ$ from the circumstellar disks. Turbulence-driven fragmentation can generate local angular momentum to produce a coplanar binary system, but which bears no particular relationship with its surrounding envelope. Instead, the observed properties conform with predictions for rotationally-driven fragmentation. If the fragments were produced at different heights or on opposite sides of the midplane in the flattened central region of a rotating core, the resulting protostars would then exhibit circumstellar disks parallel with the surrounding envelope but tilted from the orbital plane as is observed.Comment: Accepted for publication in Ap

Multiwavelength studies of G298.6−-0.0: An old GeV supernova remnant interacting with molecular clouds

Hadronic $\gamma$-ray sources associated with supernova remnants (SNRs) can serve as stopwatches for the escape of cosmic rays from SNRs, which gradually develops from highest-energy particles to lowest-energy particles with time. In this work, we analyze the 13.7~yr \emph{Fermi}-LAT data to investigate the $\gamma$-ray feature in/around the SNR G298.6$-$0.0 region. With $\gamma$-ray spatial analyses, we detect three point-like components. Among them, Src-NE is at the eastern SNR shell, and Src-NW is adjacent to the western edge of this SNR. Src-NE and Src-NW demonstrate spectral breaks at energies around/below 1.8~GeV, suggesting an old SNR age of $>$10~kyr. We also look into the X-ray emission from the G298.6$-$0.0 region, with the Chandra-ACIS data. We detected an extended keV source having a centrally filled structure inside the radio shell. The X-ray spectra are well fit by a model which assumes a collisional ionisation equilibrium of the thermal plasma, further supporting an old SNR age. Based on our analyses of the NANTEN CO- and ATCA-Parkes HI-line data, we determined a kinematic distance of $\sim$10.1~kpc from us to G298.6$-$0.0. This distance entails a large physical radius of the SNR of $\sim$15.5~pc, which is an additional evidence for an old age of $>$10~kyr. Besides, the CO data cube enables us to three-dimensionally locate the molecular clouds (MCs) which are potentially interacting with SNR G298.6$-$0.0 and could account for the hadronic $\gamma$-rays detected at Src-NE or Src-NW. Furthermore, the multiwavelength observational properties unanimously imply that the SNR--MC interaction occurs mainly in the northeast direction.Comment: Accepted by Publications of the Astronomical Society of Japan (PASJ) on 16-Jan-202

Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes

Background: Congenital dilatation of the bile-duct (CDD) is a rare, mostly sporadic, disorder that results in bile retention with severe associated complications. CDD affects mainly Asians. To our knowledge, no genetic study has ever been conducted. Methods: We aim to identify genetic risk factors by a “trio-based” exome-sequencing approach, whereby 31 CDD probands and their unaffected parents were exome-sequenced. Seven-hundred controls from the local population were used to detect gene-sets significantly enriched with rare variants in CDD patients. Results: Twenty-one predicted damaging de novo variants (DNVs; 4 protein truncating and 17 missense) were identified in several evolutionarily constrained genes (p < 0.01). Six genes carrying DNVs were associated with human developmental disorders involving epithelial, connective or bone morphologies (PXDN, RTEL1, ANKRD11, MAP2K1, CYLD, ACAN) and four linked with cholangio- and hepatocellular carcinomas (PIK3CA, TLN1 CYLD, MAP2K1). Importantly, CDD patients have an excess of DNVs in cancer-related genes (p < 0.025). Thirteen genes were recurrently mutated at different sites, forming compound heterozygotes or functionally related complexes within patients. Conclusions: Our data supports a strong genetic basis for CDD and show that CDD is not only genetically heterogeneous but also non-monogenic, requiring mutations in more than one genes for the disease to develop. The data is consistent with the rarity and sporadic presentation of CDD

Spinodal Decomposition in a Binary Polymer Mixture: Dynamic Self Consistent Field Theory and Monte Carlo Simulations

We investigate how the dynamics of a single chain influences the kinetics of early stage phase separation in a symmetric binary polymer mixture. We consider quenches from the disordered phase into the region of spinodal instability. On a mean field level we approach this problem with two methods: a dynamical extension of the self consistent field theory for Gaussian chains, with the density variables evolving in time, and the method of the external potential dynamics where the effective external fields are propagated in time. Different wave vector dependencies of the kinetic coefficient are taken into account. These early stages of spinodal decomposition are also studied through Monte Carlo simulations employing the bond fluctuation model that maps the chains -- in our case with 64 effective segments -- on a coarse grained lattice. The results obtained through self consistent field calculations and Monte Carlo simulations can be compared because the time, length, and temperature scales are mapped onto each other through the diffusion constant, the chain extension, and the energy of mixing. The quantitative comparison of the relaxation rate of the global structure factor shows that a kinetic coefficient according to the Rouse model gives a much better agreement than a local, i.e. wave vector independent, kinetic factor. Including fluctuations in the self consistent field calculations leads to a shorter time span of spinodal behaviour and a reduction of the relaxation rate for smaller wave vectors and prevents the relaxation rate from becoming negative for larger values of the wave vector. This is also in agreement with the simulation results.Comment: Phys.Rev.E in prin