The Role of Physician Assistants and Nurse Practitioners in Increasing Access to Buprenorphine

Opioid use disorder results in increasing mortality every year and is a growing concern in the United States. Buprenorphine is a safe and effective evidence-based medication to treat opioid use disorder. However, despite this evidence, there are a disproportionately low number of providers with the requisite Drug Enforcement Agency registration to prescribe buprenorphine, resulting in a significant barrier to access. In 2016, the Comprehensive Addiction and Recovery Act extended buprenorphine prescription privileges to physician assistants and nurse practitioners; however, these efforts have been restricted by state regulations. We hypothesize that access to buprenorphine is improved in areas where PA/NPs have full scope of practice in buprenorphine prescription. By evaluating the impact of the expansion of prescription authority to PA/NPs, we can better understand the impact of restricting such authority and advance efforts to increase the access to buprenorphine and thereby reduce opioid use disorder associated morbidity and mortality

An Approach to the Difference of Store Environments on Customer Experience Realms and Behaviors

The purpose of this study is to investigate the store environment if the presence of technology and different brand types have significant effect on customer experience realms and behavior intentions

Notch1 intracellular domain suppresses APP intracellular domain—Tip60–Fe65 complex mediated signaling through physical interaction

AbstractThe amyloid beta-precursor protein (APP) and the Notch receptor are both type 1 integral transmembrane proteins, and both are cleaved by presenilin-dependent gamma-secretase activity. In this study, we have demonstrated that the Notch intracellular domain (Notch1-IC) suppresses APP-intracellular domain (AICD)-mediated ROS generation and cell death after being processed by gamma secretase. Notch1-IC physically interacts with AICD, Fe65, and Tip60, thereby disrupting the association of the AICD–Fe65–Tip60 trimeric transcription activator complex in AICD signaling. AICD–Fe65–Tip60 mediated reactive oxygen species generation was found to be suppressed by Notch1-IC. Furthermore, AICD–Fe65–Tip60 was shown to mediate cell death in human neuroblastoma cells, and the overexpression of Notch1-IC inhibited cell death induced by AICD–Fe65–Tip60. Collectively, our findings indicate that Notch1-IC plays the role of a negative regulator in AICD signaling via the disruption of the AICD–Fe65–Tip60 trimeric complex

Evaluation of the high temperature solid Oxide cells using La0.1Sr0.9Co0.8Fe0.2O3-δ

The performance of the SOCs using La0.1Sr0.9Co0.8Fe0.2O3-δ (LSCF1982) was characterized by I-V measurement and electrochemical impedance spectroscopy (EIS). The distribution function of relaxation times of EIS was used to analyze the polarization resistance of the cells. The fitting was performed using the appropriate equivalent circuit through DRT analysis. Furthermore, we co-electrolyzed CO2 and H2O to obtain H2 / CO syngas as well as water splitting. The composition of syngas was investigated by gas chromatography and controlled by varying in-let gas composition

Beyond slurry-cast supercapacitor electrodes: PAN/MWNT heteromat-mediated ultrahigh capacitance electrode sheets

Supercapacitors (SCs) have garnered considerable attention as an appealing power source for forthcoming smart energy era. An ultimate challenge facing the SCs is the acquisition of higher energy density without impairing their other electrochemical properties. Herein, we demonstrate a new class of polyacrylonitrile (PAN)/multi-walled carbon tube (MWNT) heteromat-mediated ultrahigh capacitance electrode sheets as an unusual electrode architecture strategy to address the aforementioned issue. Vanadium pentoxide (V2O5) is chosen as a model electrode material to explore the feasibility of the suggested concept. The heteromat V2O5 electrode sheets are produced through one-pot fabrication based on concurrent electrospraying (for V2O5 precursor/MWNT) and electrospinning (for PAN nanofiber) followed by calcination, leading to compact packing of V2O5 materials in intimate contact with MWNTs and PAN nanofibers. As a consequence, the heteromat V2O5 electrode sheets offer three-dimensionally bicontinuous electron (arising from MWNT networks)/ion (from spatially reticulated interstitial voids to be filled with liquid electrolytes) conduction pathways, thereby facilitating redox reaction kinetics of V2O5 materials. In addition, elimination of heavy metallic foil current collectors, in combination with the dense packing of V2O5 materials, significantly increases (electrode sheet-based) specific capacitances far beyond those accessible with conventional slurry-cast electrodes.ope

A scoping review of music-based interventions for swallowing difficulties: implications for treating older adults with presbyphagia

ObjectivesPresbyphagia refers to age-related changes in the swallowing mechanism (e.g., reduced skeletal muscle strength that decreases bolus control). If left untreated, these changes can lead to dysphagia, which refers to impaired swallowing (e.g., coughing or choking when eating). Given that swallowing difficulties are common among older adults that they make up the fastest growing age group globally, the need for interventions to address presbyphagia is gaining urgency. To begin to address this need, we conducted a scoping review to analyze music therapy research aimed at enhancing swallowing function. The objective was to identify key intervention characteristics and propose clinical implications for treating presbyphagia using music therapy.MethodsThis review followed the methodological frameworks outlined by Arksey and O’Malley and Levac et al. and used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Scoping Reviews for analysis and reporting. Four electronic databases (i.e., ProQuest, PubMed, RISS, Web of Science) were searched for quantitative and qualitative studies in English or Korean that used music-based interventions to address swallowing function in older adults. Content analysis was conducted to identify and compare the main features of music interventions for swallowing difficulties among older adults.ResultsTen articles were identified and analyzed. It was found that three core components–respiration, vocalization, and singing–were employed to enhance swallowing function in populations with neurological impairments, dementia, or head and neck cancer. Notably, actions closely linked to swallowing function, such as laryngeal elevation and oral movements, were utilized therapeutically to speak or sing. Based on these characteristics, clinical implications are proposed to address presbyphagia.ConclusionSinging entails a systematic and focused incorporation of stepwise activities that can be used to address swallowing disorders. In this context, critical clinical implications that music therapists should consider when treating individuals with presbyphagia include warmup breathing, vocalizing targeting laryngeal control, and singing targeting oral motor control. This review can contribute to the expansion of music therapy with older adults and the advancement of music therapy techniques

Effect of Technological Atmosphere of Fashion Store on Online Behavior Intention: Focusing on AIDMSAS Model

Since the 1960s in-store atmospheric stimuli (e.g. color, music, and scent) have been investigated in the fashion retailing literature by reason of the great influence on consumers\u27 emotion and purchase behavior. Moreover, to increase consumers\u27 positive emotion, the experience economy by Pine and Gilmore (1999) indicates the importance of consumers\u27 in-store experiences. Enhancing consumer experience often links to in-store design aspects. To maximize consumers\u27 experience, various retailers try to adopt technology such as digital display, touch screen, augmented reality space and 3D virtual model in an offline store. Entering the era of omni-channel as seamless integrated channel from multi-channel retail environment, this study is considerably significant in that in-store experience affect customers\u27 online behavior. Technology has steadily and rapidly developed, and the use of technology in fashion retail will likely continue to spread. However, there are only few studies on the effect of technological atmosphere of a store on consumer behavior. This study, therefore, aims to identify the influence of technological atmospheric fashion store on consumer behavior including online behavior intention and purchase intention. This research demonstrates the pivotal role of in-store technology application in that purchase enhancement or an effect of e-word-of-mouth by sharing one\u27s experience. Also, it can even redound to products at stores. Hence, from the practical standpoint, implementing innovative technology features enhances customers\u27 positive attitude toward stores and products as well as the online application intention

Ultrasound of the Urinary Bladder, Revisited

Urine-filled bladder can be evaluated easily with ultrasound, and bladder tumors are usually well shown at ultrasound. Although ultrasound is not a primary imaging modality for staging of bladder tumors, it can provide general information regarding depth of tumor invasion into the proper muscle or perivesical adipose tissue. Ultrasound is also useful in showing nonneoplastic lesions of the bladder, such as stone, cystitis, diverticulum and ureterocele. Color Doppler ultrasound can show vascularity of the tumor. It also shows urine flow from the ureteral orifice or through the diverticular neck. As compared with transabdominal ultrasound, transrectal ultrasound shows bladder lesions more markedly in the dorsal wall or neck of the bladder