10 research outputs found
RENAL HEMODYNAMICS EVALUATION IN PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS WITH AND WITHOUT COMORBID HYPERTENSION
Aim. To study the features of renal arterial blood flow in patients suffering from rheumatoid arthritis, its interaction with visual markers of atherosclerosis in the presence of comorbid hypertension.Materials and methods. 113 patients with rheumatoid arthritis (RA) were enrolled into this study. Depending on the comorbidity of hypertension the patients were divided into two groups: without (n=53) and with hypertension (n=60). The comparison group consisted of 41 patients with arterial hypertension without RA. Clinical characteristics and blood biochemistry of all the patients were measured. Renal arterial resistance index (RI), presence of atherosclerotic plaques (ASP) in the carotid arteries were assessed by ultrasound scan.Results. In this investigation we report the correlation of the of renal resistive index (RI) and ultrasound signs of carotid atherosclerosis with hypertension in patients with RA. It was found out that there is the increase of RI in RA associated with the age of patients, the onset of the disease at a later age, the presence of atherosclerotic plaques in the carotid arteries and hypertension. In addition, patients with RA had a high frequency of bilateral RI increase by more than 0.7 (64%). Patients with bilateral high RI had a two-fold increase in the registration rate of atherosclerotic plaques in both group of patients with RA.Conclusion. Increased renal arteries RI in patients with RA is a factor associated with the comorbid hypertension and accompanied by more significant atherosclerotic changes in the carotid arteries in the form of an increased incidence of atherosclerotic plaques
THE RUSSIAN DATA OF INTERNATIONAL ENDORSE REGISTER (EPIDEMIOLOGIC INTERNATIONAL DAY FOR THE EVALUATION OF PATIENTS AT RISK OF VENOUS THROMBOSIS IN ACUTE HOSPITAL CARE SETTING)
Aim. To estimate a risk factor frequency of venous thromboembolism (VTE) in patients urgently hospitalized in hospitals, and also to estimate of patients part having effective prevention of VTE.Material and methods. ENDORSE (Epidemiologic International Day for the Evaluation of Patients at Risk of Venous Thrombosis in Acute Hospital Care Setting) is the international register. Patients of 40 years and older hospitalised in therapeutic departments as well as patients of 18 years and older hospitalised in surgical departments (358 hospitals in 32 countries) were included in the register. The case history analysis of all patients was performed for estimation of risk VTE and evaluation of preventive therapy quality according to American College of Chest Physicians (ACCP) Recommendation 2004.Results. Totally 68 183 patients (including 30 827 (45%) surgical patients and 37 356 (55%) therapeutic patients) were enrolled in Global ENDORSE Register. Russian centers enrolled 4 788 patients (including 2 829 (59%) surgical patients and 1 959 (41%) therapeutic patients). Totally 35 329 (51,8%) patients enrolled in Global ENDORSE Register (64,4% of surgical patients (19 842) and 41,5% of therapeutic patients (15 487)) had VTE risks. In Russia 2 188 enrolled patients (45,7%) had VTE risks (52% of surgical patients (1 470) and 36,7% of therapeutic patients (718). Totally 17 732 (50,2%) patients enrolled in Global Register ENDORSE and having VTE risks received VTE preventive therapy according to ΠΠ‘Π‘Π Recommendations 2004. In Russia 521 (23,8%) patients enrolled in Global ENDORSE Register and having VTE risks received VTE preventive therapy according to ΠΠ‘Π‘Π Recommendations 2004. It is more than 2 times less in comparison with world level (Ρ<0.001).Conclusion. There are a lot of patients with VTE risks in hospitals. It is necessary to improve preventive therapy of VTE due to better hospital management and more active use of ΠΠ‘Π‘Π Recommendations 2004
The influence of the dentifrice water with lysozyme on soft tissues of the oral cavity of patients with oral lichen planus together with dental pathology
ΠΠ·ΡΡΠ΅Π½ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π² ΡΠ»ΡΠ½Π΅ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠΈΠΏΠΈΡΠ½ΡΠΌ ΠΊΡΠ°ΡΠ½ΡΠΌ
ΠΏΠ»ΠΎΡΠΊΠΈΠΌ Π»ΠΈΡΠ°Π΅ΠΌ ΠΊΠΎΠΆΠΈ (ΠΠΠ) Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π³Π΅Π½Π΅ΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΠΌ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΈΡΠΎΠΌ (Π₯ΠΠ). ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ Ρ ΡΡΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ ΠΊ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠΌΡ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΡΠΊΠ°Π½Π΅ΠΉ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΡΡΠ°. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ Π»Π΅ΡΠ΅Π±Π½ΠΎ-ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ, Π² ΠΊΠΎΡΠΎΡΡΠΉ Π²Ρ
ΠΎΠ΄ΡΡ: ΡΠΈΡΡΠ΅ΠΌΠ½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΠΠ, ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½Π°Ρ Π³ΠΈΠ³ΠΈΠ΅Π½Π° ΠΏΠΎΠ»ΠΎΡΡΠΈ ΡΡΠ° Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π·ΡΠ±Π½ΠΎΠ³ΠΎ ΡΠ»ΠΈΠΊΡΠΈΡΠ° Β«ΠΠΈΠ·ΠΎΠΌΡΠΊΠΎΠΈΠ΄Β», Π»Π΅ΡΠ΅Π±Π½ΠΎ-ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·ΡΠ±Π½ΠΎΠΉ ΠΏΠ°ΡΡΡ Β«ΠΠ°ΠΊΠ°Π»ΡΡ Π°ΠΊΡΠΈΠ²Β». ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΎΠΊΠ°Π·Π°Π»ΡΡ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ Π₯ΠΠ Π½Π° ΡΠΎΠ½Π΅ Π§ΠΠ; ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½ΠΎ ΡΡΠ°Π½ ΠΏΡΠΎΡΠ΅ΡΡΠ² ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ Π»ΡΠΏΡΠ΄ΡΠ² Ρ ΡΠ»ΠΈΠ½Ρ Ρ
Π²ΠΎΡΠΈΡ
Π½Π° ΡΠΈΠΏΠΎΠ²ΠΈΠΉ ΡΠ΅ΡΠ²ΠΎΠ½ΠΈΠΉ ΠΏΠ»ΠΎΡΠΊΠΈΠΉ Π»ΠΈΡΠ°ΠΉ ΡΠΊΡΡΠΈ (Π§ΠΠ) Π² ΠΏΠΎΡΠ΄Π½Π°Π½Π½Ρ Π· Ρ
ΡΠΎΠ½ΡΡΠ½ΠΈΠΌ Π³Π΅Π½Π΅ΡΠ°Π»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΌ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΈΡΠΎΠΌ (Π₯ΠΠ). ΠΠ΄Π΅ΡΠΆΠ°Π½Ρ Π΄Π°Π½Ρ ΡΠ²ΡΠ΄ΡΠ°ΡΡ ΠΏΡΠΎ Π·Π½ΠΈΠΆΠ΅Π½Π½Ρ Π² ΡΠΈΡ
Ρ
Π²ΠΎΡΠΈΡ
ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ Π΄ΠΎ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ, ΡΠΎ ΠΌΠΎΠΆΠ΅ Π±ΡΡΠΈ ΠΎΠ΄Π½ΠΈΠΌ ΡΠ· ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΡΠ² ΡΡΠΊΠΎΠ΄ΠΆΠ΅Π½Π½Ρ ΡΠΊΠ°Π½ΠΈΠ½ ΠΏΠΎΡΠΎΠΆΠ½ΠΈΠ½ΠΈ ΡΠΎΡΠ°. Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ Π»ΡΠΊΡΠ²Π°Π»ΡΠ½ΠΎ-ΠΏΡΠΎΡΡΠ»Π°ΠΊΡΠΈΡΠ½ΠΈΡ
Π·Π°Ρ
ΠΎΠ΄ΡΠ², Π΄ΠΎ ΡΠΊΠΎΠ³ΠΎ Π²Ρ
ΠΎΠ΄ΡΡΡ: ΡΠΈΡΡΠ΅ΠΌΠ½Π° ΡΠ΅ΡΠ°ΠΏΡΡ Π§ΠΠ, ΠΏΡΠΎΡΠ΅ΡΡΠΉΠ½Π° Π³ΡΠ³ΡΡΠ½Π° ΠΏΠΎΡΠΎΠΆΠ½ΠΈΠ½ΠΈ ΡΠΎΡΠ° ΡΠ· Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½ΡΠΌ Π·ΡΠ±Π½ΠΎΠ³ΠΎ Π΅Π»ΡΠΊΡΠΈΡΡ Β«ΠΡΠ·ΠΎΠΌΡΠΊΠΎΡΠ΄Β», Π»ΡΠΊΡΠ²Π°Π»ΡΠ½ΠΎ-ΠΏΡΠΎΡΡΠ»Π°ΠΊΡΠΈΡΠ½ΠΎΡ Π·ΡΠ±Π½ΠΎΡ ΠΏΠ°ΡΡΠΈ Β«ΠΠ°ΠΊΠ°Π»ΡΡ Π°ΠΊΡΠΈΠ²Β». ΠΠ°ΠΏΡΠΎΠΏΠΎΠ½ΠΎΠ²Π°Π½ΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠ΅ΡΠ°ΠΏΡΡ Π²ΠΈΡΠ²ΠΈΠ²ΡΡ Π΄ΠΎΡΠΈΡΡ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΌ Π΄Π»Ρ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π₯ΠΠ Π½Π° ΡΠ»Ρ Π§ΠΠ ΡΠΈΠΏΠΎΠ²ΠΎΡ ΡΠΎΡΠΌΠΈ; Prevalence and severity of generalized parodontitis depend especially on the course of diseases affecting the oral mucosa and those ones which are characterized by involvement of the oral mucosa. These diseases include mainly lichen planus. The common pathogenic agent of generalized parodontitis and lichen planus as well as of combination of them is inflammation, as generalized parodontitis is inflammation of parardontium tissue characterized by destruction of periodontium and dental ligamentous apparatus of the alveolar bone and lichen planus is a chronic inflammatory disease of skin and oral mucosa. The purpose is to study processes of lipid peroxidation in the saliva of patients with lichen planus of the skin along with chronic generalized parodontitis. The study involved three groups of patients: Group 1was represented by patients with generalized parodontitis associated with typical form of lichen planus of skin (12 individuals). Group 2 involved patients with chronic generalized parodontitis without comorbidities, lichen planus in particular (19 individuals).
Group 3 was represented by apparently healthy donors (control group) (19 individuals). Complete examination of parodontium tissue was carried out for all patients. The parodontium condition was estimated on the basis of patientsβ complaints, dental examination over time with assessment of basic hygienic and parodontal indices.
Unstimulated mixed saliva of patients and control group were used as the material for study of lipid peroxidation
processes at organ level. In order to estimate level and character of free-radical oxidation 4 indices were applied: TBA-active products level, activity of catalase, superoxide scavenger and functional index of free-radical oxidation. It has been established that in patients with chronic generalized parodontitis as well as in patients with chronic generalized parodontitis combined with lichen planus increased level of end products of lipid peroxidation processes is observed. However, in patients with lichen planus significantly (1.8 times as much) increased content of TBA-active products indicating more pronounced activation of processes of lipid peroxidation at organ level in these patients is observed. Activity of antioxidant defense enzymes in the saliva of patients is decreased. Dramatic changes are apparent in activity of SOD in patients of both groups under study. The obtained data showed the decreased resistance to peroxidation at organ level and can be considered as one of mechanisms of affecting of oral cavity tissues. The study that has been carried out proved influence of oxidative stress in pathogenesis of lichen planus and ground the necessity to use antioxidants and antihypoxants in complex therapy. Taking the obtained data into consideration, complex therapy including systemic treatment of lichen planus and topical treatment of chronic generalized parodontitis was indicated to patients with combined course of lichen planus of typical form and chronic parodontitis of primary and mild degree. The clinical study has made it possible to establish that complex of medical and preventive measures such as systemic treatment of lichen planus, advanced hygienic care of the oral cavity with the use of Lizomucoid mouthwash, Lacalut aktiv therapeutic toothpaste is rather effective for treatment of chronic generalized parodontitis associated with lichen planus of typical form
PHYSICAL REHABILITATION OF PATIENTS WITH SIGNS OF CONNECTIVE DYSPLASIA AND JOINT PAIN SYNDROME
In the article presents the results of physical rehabilitation of patients with signs of connective tissue dysplasia andΒ articular pain. As a result of exercises to strengthen the muscles of the back, marked bending strength increase andΒ extension of the lumbar spine, rotation angles to the right and to the left, and their strength (the side muscles of the back),Β the power of flexion and extension of the cervical spine and muscle strength of the right and the left half of the neck andΒ the decrease in the intensity of joint pain
Functionally-morphological kidneys condition in patients with rheumatoid arthritis
The aim of the investigation was to study the functional-morphological state of kidney in patients with rheumatoid arthritis (RΠ). Examination was performed on 75 patients with RA and 25 healthy subjects. In addition to complete clinical and instrumental examination accepted in specialised clinic, biopsy of kidney was conducted. At 62 patients changes in an urinary deposit are taped. According to 25 nephrobiopsies in 12 cases took place mesangioproliferative variant of a chronic glomerulonephritis, the amyloidosis was detected at 5 patients, in 8 cases - vascular changes, the weak and moderate phenomena of a productive vasculitis of arterioles, the capillaries, accompanied by a focal perivascular sclerosis. Nephroprotective effect of basic therapy of RΠ was found