An Investigation of Preservice Teachers’ Knowledge of Diversity and Multicultural Literature at One University

The research study surveyed students classified as Juniors at the University of Arkansas currently enrolled in the Children’s Literature course, a required class for both Elementary Education and Childhood Education degree program students attending the University of Arkansas. The survey that was administered is the Cultural Diversity Awareness Inventory (CDAI). Additional data collected consisted of observations and interviews of students enrolled in the course. The research lasted one semester and consisted of multiple components. Through the study, the data suggests students grew in their knowledge of multicultural concepts and multicultural literature, but their growth was better measured through interviews, not the CDAI survey

Michael Sweerts (1618-1664) and the Academic Tradition

ABSTRACT Title of Document: MICHAEL SWEERTS (1618-1664) AND THE ACADEMIC TRADITION Lara Rebecca Yeager-Crasselt, Doctor of Philosophy, 2013 Directed By: Professor Arthur K. Wheelock, Jr., Department of Art History and Archaeology This dissertation examines the career of Flemish artist Michael Sweerts (1618-1664) in Brussels and Rome, and his place in the development of an academic tradition in the Netherlands in the seventeenth century. Sweerts demonstrated a deep interest in artistic practice, theory and pedagogy over the course of his career, which found remarkable expression in a number of paintings that represent artists learning and practicing their profession. In studios and local neighborhoods, Sweerts depicts artists drawing or painting after antique sculpture and live models, reflecting the coalescence of Northern and Southern attitudes towards the education of artists and the function and meaning of the early modern academy. By shifting the emphasis on Sweerts away from the Bamboccianti - the contemporary group of Dutch and Flemish genre painters who depicted Rome's everyday subject matter - to a different set of artistic traditions, this dissertation is able to approach the artist from new contextual and theoretical perspectives. It firmly situates Sweerts within the artistic and intellectual contexts of his native Brussels, examining the classicistic traditions and tapestry industry that he encountered as a young, aspiring artist. It positions him and his work in relation to the Italian academic culture he experienced in Rome, as well as investigating his engagement with the work of the Flemish sculptor François Duquesnoy (1597-1643) and the French painter Nicholas Poussin (1594-1665). The breadth of Sweerts' artistic and academic pursuits ultimately provide significant insight into the ways in which the Netherlandish artistic traditions of naturalism and working from life coalesced with the theoretical and practical aims of the academy. This dissertation thus seeks to broaden our understanding of the artistic exchanges between the North and South, and the evolving role of the artist and the academy in the changing artistic landscape of the Netherlands in the mid-seventeenth century

Hemagglutinin Spatial Distribution Shifts in Response to Cholesterol in the Influenza Viral Envelope

AbstractInfluenza virus delivers its genome to the host cytoplasm via a process of membrane fusion mediated by the viral hemagglutinin protein. Optimal fusion likely requires multiple hemagglutinin trimers, so the spatial distribution of hemagglutinin on the viral envelope may influence fusion mechanism. We have previously shown that moderate depletion of cholesterol from the influenza viral envelope accelerates fusion kinetics even though it decreases fusion efficiency, both in a reversible manner. Here, we use electron cryo-microscopy to measure how the hemagglutinin lateral density in the viral envelope changes with cholesterol extraction. We extract this information by measuring the radial distribution function of electron density in >4000 viral images per sample, assigning hemagglutinin density by comparing images with and without anti-HA Fab bound. On average, hemagglutinin trimers move closer together: we estimate that the typical trimer-trimer spacing reduces from 94 to 84 Å when ∼90% of cholesterol is removed from the viral membrane. Upon restoration of viral envelope cholesterol, this spacing once again expands. This finding can qualitatively explain the observed changes to fusion kinetics: contemporary models from single-virus microscopy are that fusion requires the engagement of several hemagglutinin trimers in close proximity. If removing cholesterol increases the lateral density of hemagglutinin, this should result in an increase in the rate of fusion

Association of Rideshare-Based Transportation Services and Missed Primary Care Appointments: A Clinical Trial

In a pragmatic trial, offering complimentary ridesharing services broadly to Medicaid patients did not reduce rates of missed primary care appointments. The uptake of free rides was low, and rates of missed appointments remained unchanged at 36%. Efforts to reduce missed appointments due to transportation barriers may require more targeted approaches

Control of telomere length by a trimming mechanism that involves generation of t-circles

Telomere lengths are maintained in many cancer cells by the ribonucleoprotein enzyme telomerase but can be further elongated by increasing telomerase activity through the overexpression of telomerase components. We report here that increased telomerase activity results in increased telomere length that eventually reaches a plateau, accompanied by the generation of telomere length heterogeneity and the accumulation of extrachromosomal telomeric repeat DNA, principally in the form of telomeric circles (t-circles). Telomeric DNA was observed in promyelocytic leukemia bodies, but no intertelomeric copying or telomere exchange events were identified, and there was no increase in telomere dysfunction-induced foci. These data indicate that human cells possess a mechanism to negatively regulate telomere length by trimming telomeric DNA from the chromosome ends, most likely by t-loop resolution to form t-circles. Additionally, these results indicate that some phenotypic characteristics attributed to alternative lengthening of telomeres (ALT) result from increased mean telomere length, rather than from the ALT mechanism itself

SIO-ASCO Guideline on Integrative Medicine for Cancer Pain Management: Implications for Racial and Ethnic Pain Disparities

Racial and ethnic disparities in pain management pose major challenges to equitable cancer care delivery. These disparities are driven by complex interactions between patient-, provider-, and system-related factors that resist reductionistic solutions and require innovative, holistic approaches. On September 19, 2022, the Society for Integrative Oncology and the American Society of Clinical Oncology published a joint guideline to provide evidence-based recommendations on integrative medicine for cancer pain management. Integrative medicine, which combines conventional treatments with complementary modalities from cultures and traditions around the world, are uniquely equipped to resonate with diverse cancer populations and fill existing gaps in pain management. Although some complementary modalities, such as music therapy and yoga, lack sufficient evidence to make a specific recommendation, other modalities, such as acupuncture, massage, and hypnosis, demonstrated an intermediate level of evidence, resulting in moderate strength recommendations for their use in cancer pain management. However, several factors may hinder real-world implementation of the Society for Integrative Oncology and the American Society of Clinical Oncology guideline and must be addressed to ensure equitable pain management for all communities. These barriers include, but are not limited to, the lack of insurance coverage for many complementary therapies, the limited diversity and availability of complementary therapy providers, the negative social norms surrounding complementary therapies, the underrepresentation of racial and ethnic subgroups in the clinical research of complementary therapies, and the paucity of culturally attuned interventions tailored to diverse individuals. This commentary examines both the challenges and the opportunities for addressing racial and ethnic disparities in cancer pain management through integrative medicine

Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk

Previously, a candidate gene linkage approach on brother pairs affected with prostate cancer identified a locus of prostate cancer susceptibility at D3S1234 within the fragile histidine triad gene (FHIT), a tumor suppressor that induces apoptosis. Subsequent association tests on 16 SNPs spanning approximately 381 kb surrounding D3S1234 in Americans of European descent revealed significant evidence of association for a single SNP within intron 5 of FHIT. In the current study, resequencing and genotyping within a 28.5 kb region surrounding this SNP further delineated the association with prostate cancer risk to a 15 kb region. Multiple SNPs in sequences under evolutionary constraint within intron 5 of FHIT defined several related haplotypes with an increased risk of prostate cancer in European-Americans. Strong associations were detected for a risk haplotype defined by SNPs 138543, 142413, and 152494 in all cases (Pearson's χ2 = 12.34, df 1, P = 0.00045) and for the homozygous risk haplotype defined by SNPs 144716, 142413, and 148444 in cases that shared 2 alleles identical by descent with their affected brothers (Pearson's χ2 = 11.50, df 1, P = 0.00070). In addition to highly conserved sequences encompassing SNPs 148444 and 152413, population studies revealed strong signatures of natural selection for a 1 kb window covering the SNP 144716 in two human populations, the European American (π = 0.0072, Tajima's D= 3.31, 14 SNPs) and the Japanese (π = 0.0049, Fay & Wu's H = 8.05, 14 SNPs), as well as in chimpanzees (Fay & Wu's H = 8.62, 12 SNPs). These results strongly support the involvement of the FHIT intronic region in an increased risk of prostate cancer. © 2008 Ding et al

Model-observation and reanalyses comparison at key locations for heat transport to the Arctic: Assessment of key lower latitude influences on the Arctic and their simulation

Blue-Action Work Package 2 (WP2) focuses on lower latitude drivers of Arctic change, with a focus on the influence of the Atlantic Ocean and atmosphere on the Arctic. In particular, warm water travels from the Atlantic, across the Greenland-Scotland ridge, through the Norwegian Sea towards the Arctic. A large proportion of the heat transported northwards by the ocean is released to the atmosphere and carried eastward towards Europe by the prevailing westerly winds. This is an important contribution to northwestern Europe's mild climate. The remaining heat travels north into the Arctic. Variations in the amount of heat transported into the Arctic will influence the long term climate of the Northern Hemisphere. Here we assess how well the state of the art coupled climate models estimate this northwards transport of heat in the ocean, and how the atmospheric heat transport varies with changes in the ocean heat transport. We seek to improve the ocean monitoring systems that are in place by introducing measurements from ocean gliders, Argo floats and satellites. These state of the art computer simulations are evaluated by comparison with key trans-Atlantic observations. In addition to the coupled models ‘ocean-only’ evaluations are made. In general the coupled model simulations have too much heat going into the Arctic region and the transports have too much variability. The models generally reproduce the variability of the Atlantic Meridional Ocean Circulation (AMOC) well. All models in this study have a too strong southwards transport of freshwater at 26°N in the North Atlantic, but the divergence between 26°N and Bering Straits is generally reproduced really well in all the models. Altimetry from satellites have been used to reconstruct the ocean circulation 26°N in the Atlantic, over the Greenland Scotland Ridge and alongside ship based observations along the GO-SHIP OVIDE Section. Although it is still a challenge to estimate the ocean circulation at 26°N without using the RAPID 26°N array, satellites can be used to reconstruct the longer term ocean signal. The OSNAP project measures the oceanic transport of heat across a section which stretches from Canada to the UK, via Greenland. The project has used ocean gliders to great success to measure the transport on the eastern side of the array. Every 10 days up to 4000 Argo floats measure temperature and salinity in the top 2000m of the ocean, away from ocean boundaries, and report back the measurements via satellite. These data are employed at 26°N in the Atlantic to enable the calculation of the heat and freshwater transports. As explained above, both ocean and atmosphere carry vast amounts of heat poleward in the Atlantic. In the long term average the Atlantic ocean releases large amounts of heat to the atmosphere between the subtropical and subpolar regions, heat which is then carried by the atmosphere to western Europe and the Arctic. On shorter timescales, interannual to decadal, the amounts of heat carried by ocean and atmosphere vary considerably. An important question is whether the total amount of heat transported, atmosphere plus ocean, remains roughly constant, whether significant amounts of heat are gained or lost from space and how the relative amount transported by the atmosphere and ocean change with time. This is an important distinction because the same amount of anomalous heat transport will have very different effects depending on whether it is transported by ocean or the atmosphere. For example the effects on Arctic sea ice will depend very much on whether the surface of the ice experiences anomalous warming by the atmosphere versus the base of the ice experiencing anomalous warming from the ocean. In Blue-Action we investigated the relationship between atmospheric and oceanic heat transports at key locations corresponding to the positions of observational arrays (RAPID at 26°N, OSNAP at ~55N, and the Denmark Strait, Iceland-Scotland Ridge and Davis Strait at ~67N) in a number of cutting edge high resolution coupled ocean-atmosphere simulations. We split the analysis into two different timescales, interannual to decadal (1-10 years) and multidecadal (greater than 10 years). In the 1-10 year case, the relationship between ocean and atmosphere transports is complex, but a robust result is that although there is little local correlation between oceanic and atmospheric heat transports, Correlations do occur at different latitudes. Thus increased oceanic heat transport at 26°N is accompanied by reduced heat transport at ~50N and a longitudinal shift in the location of atmospheric flow of heat into the Arctic. Conversely, on longer timescales, there appears to be a much stronger local compensation between oceanic and atmospheric heat transport i.e. Bjerknes compensation