7 research outputs found
ΠΠΠΠΠΠ‘Π¦ΠΠΠΠΠΠΠ ΠΠ«Π ΠΠΠ Π‘ΠΠΠΠΠΠΠΠ ΠΠΠΠΠΠ«Π ΠΠΠΠ₯ΠΠ Π Π’ΠΠ₯ΠΠΠΠΠΠΠ ΠΠΠ£Π§ΠΠΠΠ― ΠΠΠΠΠΠΠΠΠ ΠΠΠΠΠ ΠΠ Π ΠΠΠ§ΠΠΠ€ΠΠΠ¦ΠΠ
There was made an attempt to link interdisciplinary research methodically, from clinical diagnostic techniques, modern instrumental, laboratory and basic research to their implementation in practice. The experience of several partner groups studying the brainΒ in HIV infection was analyzed and summarized. It was based on an interdisciplinary approach, the goals and authorities of infectious disease specialists,Β psychiatrists, neurologists, radiologists, laboratory doctors, clinical examination algorithm, the role ofΒ history and interview, express-diagnostic of cognitive functions, specialized psychiatric, neurologicalΒ diagnosis, conclusion of clinical psychologists, indications for radiology methods. The choice and analysis of radiological and instrumental methods, the volumeΒ and structure of laboratory methods of central nervous system study were justified. The role of molecular genetic studies of HIV inΒ blood and cerebrospinal fluid, the identification of drug-resistant forms of the virus was determined when choosing the therapy.Π‘Π΄Π΅Π»Π°Π½Π° ΠΏΠΎΠΏΡΡΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈ ΡΠ²ΡΠ·Π°ΡΡ ΠΌΠ΅ΠΆΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, Π½Π°ΡΠΈΠ½Π°Ρ Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΠ΅ΠΌΠΎΠ²,Β ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
, Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΈ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄ΠΎ ΠΈΡ
ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π² ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Β ΠΈ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½ ΠΎΠΏΡΡ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
ΠΏΠ°ΡΡΠ½Π΅ΡΡΠΊΠΈΡ
ΠΊΠΎΠ»Π»Π΅ΠΊΡΠΈΠ²ΠΎΠ² ΠΏΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΏΡΠΈ ΠΠΠ§-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. Π ΠΎΡΠ½ΠΎΠ²ΡΒ Π»Π΅Π³Π»ΠΈ ΠΌΠ΅ΠΆΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄, Π·Π°Π΄Π°ΡΠΈ ΠΈ ΠΏΠΎΠ»Π½ΠΎΠΌΠΎΡΠΈΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½ΠΈΡΡΠΎΠ², Π½Π°ΡΠΊΠΎΠ»ΠΎΠ³ΠΎΠ²-ΠΏΡΠΈΡ
ΠΈΠ°ΡΡΠΎΠ², Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΎΠ², ΡΠ°Π΄ΠΈΠΎΠ»ΠΎΠ³ΠΎΠ², Π²ΡΠ°ΡΠ΅ΠΉ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΉ ΡΠ»ΡΠΆΠ±Ρ, Π°Π»Π³ΠΎΡΠΈΡΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΡΠΎΠ»Ρ Π°Π½Π°ΠΌΠ½Π΅Π·Π° ΠΈ ΠΎΠΏΡΠΎΡΠ°, ΡΠΊΡΠΏΡΠ΅ΡΡ-Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ
Β ΡΡΠ½ΠΊΡΠΈΠΉ, ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΠ· ΠΏΡΠΈΡ
ΠΈΠ°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ, Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ, Π·Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΎΠ², ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡ Π΄Π»ΡΒ ΡΠ°Π΄ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Ρ Π²ΡΠ±ΠΎΡ ΠΈ Π°Π½Π°Π»ΠΈΠ· ΡΠ°Π΄ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΡΠ΅Π½ΠΊΠΈ Π¦ΠΠ‘, ΠΎΠ±ΡΠ΅ΠΌΒ ΠΈ ΡΡΡΡΠΊΡΡΡΠ° Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² Π¦ΠΠ‘. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΠΎΠ»Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΠΠ§Β Π² ΠΊΡΠΎΠ²ΠΈ ΠΈ ΡΠΏΠΈΠ½Π½ΠΎΠΌΠΎΠ·Π³ΠΎΠ²ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ, Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΡΠΎΡΠΌ Π²ΠΈΡΡΡΠ°, ΡΡΠ΅Ρ ΠΏΡΠΈ Π²ΡΠ±ΠΎΡΠ΅ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ
EFFECT OF NEURODEGENERATIVE CHANGES IN THE BRAIN ON THE FORMATION OF THE DISEASE CLINICAL PICTURE IN PATIENTS WITH MULTIPLE SCLEROSIS
The aim of the study was to determine the relationship of global and regional cerebral atrophy and volume of demyelination lesions in the brain with a clinical picture in patients with multiple sclerosis (MS). The study involved 55 patients with MS. Control group included 22 healthy volunteers. Patients were divided into groups according to the severity of disability, the type and duration of disease. Assessment of general and regional atrophy was performed by post-process volumetric segmentation of MRI data, which was acquired at 3T Philips Achieva scanner. The post-processing was done with the FreeSurfer software. It is shown that in MS patients brain atrophy develops both by means of gray matter (including the cortex and subcortical structures), and white matter, along with demyelination. Global and regional atrophy is associated with the severity of disability of patients according to EDSS scale, but not with the duration and type of the disease. Neurodegenerative changes of brain structures evolve with different rates, have different intensity and determine the set of symptoms of neurological impairment and severity of disability, which indicates the presence of certain patterns of the process of atrophy in the brain, forming the clinical picture of the disease