Anhydrous proton conducting poly(vinyl alcohol) (PVA)/ poly(2-acrylamido-2-methylpropane sulfonic acid) (PAMPS)/1,2,4-triazole composite membrane

The design and fabrication of anhydrous proton exchange membranes are critically important for high temperature proton exchange membrane fuel cell (HT-PEMFC) operating between 100 and 200 °C. Herein, we demonstrate a novel proton conducting membrane consisting of poly(vinyl alcohol) (PVA), poly (2-acrylamido-2-methylpropane sulfonic acid) (PAMPS) and 1,2,4-triazole, which was fabricated by physical blending, casting and solvent evaporation techniques. The in-situ chemical cross-linking was performed by glutaraldehyde (GA) to improve the water management of the membranes. The molecular structure of the membranes and intermolecular interactions between the constituents were confirmed by Fourier-transform infrared spectroscopy (FT-IR). The surface and cross-section morphologies of the membranes were observed by scanning electron microscopy (SEM). The thermal stability performance of the membranes was studied with thermogravimetric analysis (TGA). In order to determine the physico-chemical properties of the membranes, water uptake (WU), dimensional change and ion exchange capacity (IEC) tests were carried out. The proton conductivities of composite membranes increase with the temperature and the temperature dependencies exhibit an Arrhenius behavior. Proton conductivity measurements revealed an optimum ratio between PAMPS and 1,2,4-triazole content to achieve higher proton conductivity. In anhydrous state at 150 °C, the highest proton conductivity measured was 0.002 S/cm for PVA:PAMPS:1,2,4-triazole (1:1:1) composition. Overall, our investigation showed that 1,2,4-triazole is a promising proton carrier reagent above 100 °C when it is embedded into appropriate host polymers

Gas permeation through single-crystal ZIF-8 membranes

Dataset supporting publication: Chen Chen, Aydin Ozcan, A. Ozgur Yazaydin and Bradley P. Ladewig, Gas permeation through single-crystal ZIF-8 membranes, Journal of Membrane Science, https://doi.org/10.1016/j.memsci.2019.01.027 Dataset supporting preprint: Chen, Chen; Ozcan, Aydin; Yazaydin, A. Ozgur; Ladewig, Bradley (2019): Gas Permeation Through Single-Crystal ZIF-8 Membranes. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.7571186.v1Dataset supporting publication: Chen Chen, Aydin Ozcan, A. Ozgur Yazaydin and Bradley P. Ladewig, Gas permeation through single-crystal ZIF-8 membranes, Journal of Membrane Science, https://doi.org/10.1016/j.memsci.2019.01.027 Dataset supporting preprint: Chen, Chen; Ozcan, Aydin; Yazaydin, A. Ozgur; Ladewig, Bradley (2019): Gas Permeation Through Single-Crystal ZIF-8 Membranes. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.7571186.v

Synergistic Interaction of Paclitaxel and Curcumin with Cyclodextrin Polymer Complexation in Human Cancer Cells

The use of cytotoxic chemotherapic agents is the most common method for the treatment of metastatic cancers. Poor water solubility and low efficiency of chemotherapic agents are among the major hurdles of effective chemotherapy treatments. Curcumin and paclitaxel are well-known chemotherapic agents with poor water solubility and undesired side effects. In this study, a novel drug nanocarrier system was formulated by encapsulating curcumin and paclitaxel in poly­(β-cyclodextrin triazine) (PCDT) for the therapy of four cancer models; ovarian, lung, prostate, and breast cancer. Cell viability and colony formation assays revealed enhanced curcumin cytotoxicity upon complexation. Annexin V apoptotic studies showed that the PCDT complexation improved curcumin induced apoptosis in human ovarian cancer cell lines A2780 and SKOV-3, human nonsmall cell lung carcinoma cell line H1299, and human prostate cancer line DU-145, while no significant effect was observed with paclitaxel/PCDT complexation. The bioactivity of combining curcumin and paclitaxel was also investigated. A synergism was found between curcumin and paclitaxel, particularly when complexed with PCDT on A2780, SKOV-3, and H1299 cancer cell lines

Metal-organic framework MIL-101 for adsorption and effect of terminal water molecules: From quantum mechanics to molecular simulation

10.1021/la904502hLangmuir26118743-8750LANG

A highly hydrophobic metal-organic framework Zn(BDC)(TED)0.5 for adsorption and separation of CH3OH/H2O and CO 2/CH4: An integrated experimental and simulation study

10.1021/jp1003177Journal of Physical Chemistry C114146602-660