Reflecting on the Last 10 Years: The Research and Education at the Laboratory of Nutraceuticals and Functional Foods Science(Nakashima Touichirou Memorial Programme) of TUMSAT

本学寄附講座として開講されたヘルスフード科学（中島董一郎記念）寄附講座は、平成23 年度をもって10 年となり終了する。「予防医学のための機能性食品、すなわちヘルスフードの新規探索、機能解明、用途開発に関する教育・研究」を目的として運命共同体としての活動をしてきた。さらに、海外調査研修、展示会出展、食品産業界との連携や社会一般に向けた啓発活動を積極的に行い、寄附者のCSR の考えに基づき運営をして来た。The Laboratory of Nutraceutical and Functional Foods Science (Nakashima Touichirou Memorial Programme), an endowed programme, will complete its term at the end of the 2011 academic year. Under the objective of “researching functional foods as preventive medicine”, the members of this programme have rigorously pursued the novel discovery, functional analysis, and application development of health foods as an independentresearch unit. Furthermore, following CSR’s (the endower’s) vision, we have participated in a number of overseas research trips, conferences and exhibitions, while proactively collaborating with food industries and positively contributing to society’s well being through educational activities.東京海洋大学大学院海洋科学技術研究科　へルスフード科学（中島董一郎記念）寄附講

Methanol and Butanol Extracts of Paeonia lutea

Squamous cell carcinoma (SCC) is one of the most common cancers of the head and neck region worldwide and is generally treated surgically in combination with radiotherapy and/or chemotherapy. However, anticancer agents have numerous serious side effects, and alternative, less toxic agents that are effective as chemotherapeutics for SCC are required. The Paeoniaceae family is widely used in traditional Chinese medicine. We examined methanol and butanol extracts of Paeonia lutea (P. lutea) leaves for their potential as an anticancer agent. Both extracts decreased the proliferation of SCC cells, induced apoptotic cell death, and modulated migration, adhesion, chemotaxis, and haptotaxis in an extracellular matrix- (ECM-) dependent manner due to altered expression of several integrin subunits. Subsequently, SCC cells were subcutaneously transplanted into athymic nude mice; the extracts reduced the metastasis of SCC cells but had little effect on the volume of the primary tumor or survival or body weight of the mice. The results suggest that the extracts may hold promise for preventing cancer metastasis

Osteoclast-Forming Suppressive Compounds from Makomotake, Zizania latifolia Infected with Ustilago esculenta

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