Long Noncoding RNA LINC00857 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cell through miR-1306/Vimentin Axis

Colorectal cancer is a commonly diagnosed cancer and the leading cause of cancer-related death which still increasing in many countries. The lack of biomarkers for early detection and clinic treatment results in high morbidity and mortality. The novel role of long noncoding RNA LINC00857 on cell proliferation migration and invasion was explored in this article. The expression level of LINC00857 in colorectal cancer tissue samples and cells was determined notably higher than normal tissue samples and cells. Silence LINC00857 can significantly inhibit colorectal cancer cell viability and metastasis in vitro. Moreover, LINC00857 depletion caused cell accumulation in the G0/G1 phase. In addition, we recognized the novel LINC00857–miR-1306–vimentin axis and demonstrated it by dual-luciferase reporter assay. And this signaling axis could be considered as the target for colorectal cancer treatment. In conclusion, LINC00857 can promote colorectal cancer progress by sponging miR-1306 and upregulate vimentin to accelerate the epithelial-mesenchymal transition process

Study of the EAS size spectrum in thermal neutrons measured by the PRISMA-YBJ array

An Extensive Air Shower array of a novel type has been constructed in Tibet at an altitude of 4300 m above sea level. It consists of specially designed scintillator en-detectors capable of measuring two main EAS components: hadrons (n) and electrons (e). Results of the experiment are presented. It is demonstrated that the EAS integral distribution in the number of thermal neutrons can be well fitted by a single power law function. Comparison with detailed Monte-Carlo simulations using CORSIKA6.9 and GEANT4.10 codes are also shown

Study of the EAS size spectrum in thermal neutrons measured by the PRISMA-YBJ array

An Extensive Air Shower array of a novel type has been constructed in Tibet at an altitude of 4300 m above sea level. It consists of specially designed scintillator en-detectors capable of measuring two main EAS components: hadrons (n) and electrons (e). Results of the experiment are presented. It is demonstrated that the EAS integral distribution in the number of thermal neutrons can be well fitted by a single power law function. Comparison with detailed Monte-Carlo simulations using CORSIKA6.9 and GEANT4.10 codes are also shown

Exotic geophysical phenomena observed in an environmental neutron flux study using EAS PRISMA detectors

Some exotic geophysical events are observed by a global net of electron-neutron detectors (en-detectors) developed in the framework of the PRISMA EAS project. Our en-detectors running both on the Earth's surface and underground are continuously measuring the environmental thermal neutron flux. Thermal neutrons are in equilibrium with media and are therefore sensitive to many geophysical phenomena, which are exotic for people studying ultra high-energy cosmic rays or carrying out low background experiments deep underground

The PRISMA-LHAASO project: Status and overview

The status of and main features of the PRISMA-LHAASO project are presented. We discuss here the science project and some preliminary results obtained with the PRISMA prototype

Exotic geophysical phenomena observed in an environmental neutron flux study using EAS PRISMA detectors

Some exotic geophysical events are observed by a global net of electron-neutron detectors (en-detectors) developed in the framework of the PRISMA EAS project. Our en-detectors running both on the Earth's surface and underground are continuously measuring the environmental thermal neutron flux. Thermal neutrons are in equilibrium with media and are therefore sensitive to many geophysical phenomena, which are exotic for people studying ultra high-energy cosmic rays or carrying out low background experiments deep underground