Iron production in the State of Qin during the Warring States period

This thesis focuses on the Qin State during the Warring States period as a political entity, and sets out to explore its iron production industry, aiming to model and understand the technological system adopted for iron production, tracing changes through time as well as exploring the interaction between the technology and its social context. Through the scientific study of archaeological iron unearthed from Qin civilian cemeteries and workshop across the Guanzhong Plain, it has been demonstrated that the iron production in the Qin state was predominantly based on cast iron smelting from the later stage of the middle Warring States period, with multiple technical pathways developed to cost-effectively produce various types of iron products. The mould casting process was adopted for producing most of the daily use artefacts and farming implements, with controlled cooling and annealing process applied to improve the mechanical strength of cast iron. Annealing and chaogang/fining techniques were used to convert cast iron into soft iron/steel, then further manufacture into tools and weapons through the forging process. Through the comparison between different technological choices, it has been demonstrated that the whole technological system was developed based on the aim to achieve optimum cost-effectiveness with the available techniques, while the technological tradition and cultural preferences also played key roles for the adoption of such an iron production system. Based on a synthesis of current research results, it has been argued that the State of Qin made the transition from bloomery iron smelting to cast iron smelting during the middle stage of the Warring States period, then quickly developed a functional and efficient technological system by the end of the Warring States period. This iron production system greatly promoted the development of the Qin state, mainly in the field of agricultural production, while weapon production for the Qin army also benefited from such an iron industry, which laid the foundations for the success of the unification war

A Multivariate Approach to Investigate Metallurgical Technology: The Case of the Chinese Ritual Bronzes

Abstract Research into ancient Chinese metallurgy has flourished over recent years with the accumulation of analytical data reflecting the needs of so many archaeological finds. However, the relationship between technology and society is unlikely to be revealed simply by analysing more artefacts. This is particularly evident in the debates over the sources of metals used to manufacture the Chinese ritual bronzes of the Shang (c. 1500-1046 BCE), Western Zhou (c. 1046–771 BCE) and Eastern Zhou (c. 771–256 BCE) dynasties. This article recognises that approaches to analytical data often fail to provide robust platforms from which to investigate metallurgical technology within its wider social and cultural contexts. To address this issue, a recently developed multivariate approach is applied to over 300 Chinese ritual bronzes from legacy data sets and nearly 100 unearthed copper-based objects from Anyang and Hanzhong. Unlike previous investigations that have relied predominantly on interpreting lead isotope signatures, the compositional analyses presented here indicate that copper and lead used to manufacture the bronzes are derived from mining progressively deeper ores in the same deposits rather than seeking out new sources. It is proposed that interpretations of social, cultural and technological change predicated on the acquisition of metals from disparate regions during the Chinese Bronze Age may need to be revised

Pure exploration in multi-armed bandits with low rank structure using oblivious sampler

In this paper, we consider the low rank structure of the reward sequence of the pure exploration problems. Firstly, we propose the separated setting in pure exploration problem, where the exploration strategy cannot receive the feedback of its explorations. Due to this separation, it requires that the exploration strategy to sample the arms obliviously. By involving the kernel information of the reward vectors, we provide efficient algorithms for both time-varying and fixed cases with regret bound $O(d\sqrt{(\ln N)/n})$. Then, we show the lower bound to the pure exploration in multi-armed bandits with low rank sequence. There is an $O(\sqrt{\ln N})$ gap between our upper bound and the lower bound.Comment: 15 page

AdaEvo: Edge-Assisted Continuous and Timely DNN Model Evolution for Mobile Devices

Mobile video applications today have attracted significant attention. Deep learning model (e.g. deep neural network, DNN) compression is widely used to enable on-device inference for facilitating robust and private mobile video applications. The compressed DNN, however, is vulnerable to the agnostic data drift of the live video captured from the dynamically changing mobile scenarios. To combat the data drift, mobile ends rely on edge servers to continuously evolve and re-compress the DNN with freshly collected data. We design a framework, AdaEvo, that efficiently supports the resource-limited edge server handling mobile DNN evolution tasks from multiple mobile ends. The key goal of AdaEvo is to maximize the average quality of experience (QoE), e.g. the proportion of high-quality DNN service time to the entire life cycle, for all mobile ends. Specifically, it estimates the DNN accuracy drops at the mobile end without labels and performs a dedicated video frame sampling strategy to control the size of retraining data. In addition, it balances the limited computing and memory resources on the edge server and the competition between asynchronous tasks initiated by different mobile users. With an extensive evaluation of real-world videos from mobile scenarios and across four diverse mobile tasks, experimental results show that AdaEvo enables up to 34% accuracy improvement and 32% average QoE improvement.Comment: Accepted by IEEE Transactions on Mobile Computing 202

Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress.

The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple antioxidants have proven ineffective in attenuating the deleterious effects of PQ. Adiponectin, which shows anti-oxidative and antinitrative effects, may have the potential to reduce PQ-mediated injury. The present study determined the protective action of globular domain adiponectin (gAd) on PQ-induced lung injury, and attempted to elucidate the underlying mechanism or mechanisms of action. BALB/c mice were administered PQ, with and without 12 or 36 h of gAd pre-treatment. The pulmonary oxidative/nitrative status was assessed by measuring pulmonary O2(•-), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxy-2-dydeoxy guanosine (8-OHdG) production, and blood 3-Nitrotyrosine (3-NT). At a dose of 20 mg/kg, PQ markedly increased O2(•-), SOD, MDA, NO and 8-OHdG production 3 h post-administration, but did not significantly increase 3-NT levels until 12 h. gAd inhibited these changes in a dose-dependent manner, via transient activation of MDA, followed by attenuation of MDA formation from 6 h onwards. Histological analysis demonstrated that gAd decreased interstitial edema and inflammatory cell infiltration. These results suggest that gAd protects against PQ-induced lung injury by mitigating oxidative/nitrative stress. Furthermore, gAd may be a potential therapeutic agent for PQ-induced lung injury, and further pharmacological studies are therefore warranted

The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas

<p>Abstract</p> <p>Background</p> <p>Claudin-6 is a candidate tumor suppressor gene in breast cancer, and has been shown to be regulated by DNA methylation and histone modification in breast cancer lines. However, the expression of claudin-6 in breast invasive ductal carcinomas and correlation with clinical behavior or expression of other markers is unclear. We considered that the expression pattern of claudin-6 might be related to the expression of DNA methylation associated proteins (methyl-CpG binding protein 2 (MeCP2) and DNA methyltransferase 1 (DNMT1)) and histone modification associated proteins (histone deacetylase 1 (HDAC1), acetyl-histone H3 (H3Ac) and acetyl- histone H4 (H4Ac)).</p> <p>Methods</p> <p>We have investigated the expression of claudin-6, MeCP2, HDAC1, H3Ac and H4Ac in 100 breast invasive ductal carcinoma tissues and 22 mammary gland fibroadenoma tissues using immunohistochemistry.</p> <p>Results</p> <p>Claudin-6 protein expression was reduced in breast invasive ductal carcinomas (<it>P </it>< 0.001). In contrast, expression of MeCP2 (<it>P </it>< 0.001), DNMT1 (<it>P </it>= 0.001), HDAC1 (<it>P </it>< 0.001) and H3Ac (<it>P </it>= 0.004) expressions was increased. Claudin-6 expression was inversely correlated with lymph node metastasis (<it>P </it>= 0.021). Increased expression of HDAC1 was correlated with histological grade (<it>P </it>< 0.001), age (<it>P </it>= 0.004), clinical stage (<it>P </it>= 0.007) and lymph node metastasis (<it>P </it>= 0.001). H3Ac expression was associated with tumor size (<it>P </it>= 0.044) and clinical stage of cancers (<it>P </it>= 0.034). MeCP2, DNMT1 and H4Ac expression levels did not correlate with any of the tested clinicopathological parameters (<it>P </it>> 0.05). We identified a positive correlation between MeCP2 protein expression and H3Ac and H4Ac protein expression.</p> <p>Conclusions</p> <p>Our results show that claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas and is an important correlate with lymphatic metastasis, but claudin-6 down-regulation was not correlated with upregulation of the methylation associated proteins (MeCP2, DNMT1) or histone modification associated proteins (HDAC1, H3Ac, H4Ac). Interestingly, the expression of MeCP2 was positively correlated with the expression of H3Ac and H3Ac protein expression was positively correlated with the expression of H4Ac in breast invasive ductal carcinoma</p> <p>Virtual slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/4549669866581452</url></p

Biokinetics and Subchronic Toxic Effects of Oral Arsenite, Arsenate, Monomethylarsonic Acid, and Dimethylarsinic Acid in v-Ha-ras Transgenic (Tg.AC) Mice

Previous research demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment increased the number of skin papillomas in v-Ha-ras transgenic (Tg.AC) mice that had received sodium arsenite [(As(III)] in drinking water, indicating that this model is useful for studying the toxic effects of arsenic in vivo. Because the liver is a known target of arsenic, we examined the pathophysiologic and molecular effects of inorganic and organic arsenical exposure on Tg.AC mouse liver in this study. Tg.AC mice were provided drinking water containing As(III), sodium arsenate [As(V)], monomethylarsonic acid [(MMA(V)], and 1,000 ppm dimethylarsinic acid [DMA(V)] at dosages of 150, 200, 1,500, or 1,000 ppm as arsenic, respectively, for 17 weeks. Control mice received unaltered water. Four weeks after initiation of arsenic treatment, TPA at a dose of 1.25 μg/200 μL acetone was applied twice a week for 2 weeks to the shaved dorsal skin of all mice, including the controls not receiving arsenic. In some cases arsenic exposure reduced body weight gain and caused mortality (including moribundity). Arsenical exposure resulted in a dose-dependent accumulation of arsenic in the liver that was unexpectedly independent of chemical species and produced hepatic global DNA hypomethylation. cDNA microarray and reverse transcriptase–polymerase chain reaction analysis revealed that all arsenicals altered the expression of numerous genes associated with toxicity and cancer. However, organic arsenicals [MMA(V) and DMA(V)] induced a pattern of gene expression dissimilar to that of inorganic arsenicals. In summary, subchronic exposure of Tg.AC mice to inorganic or organic arsenicals resulted in toxic manifestations, hepatic arsenic accumulation, global DNA hypomethylation, and numerous gene expression changes. These effects may play a role in arsenic-induced hepatotoxicity and carcinogenesis and may be of particular toxicologic relevance