Nicotinamide's Ups and Downs:Consequences for Fertility, Development, Longevity and Diseases of Poverty and Affluence

Aims and Scope: To further explore the role of dietary nicotinamide in both brain development and diseases, particularly those of ageing. Articles cover neurodegenerative disease and cancer. Also discussed are the effects of nicotinamide, contained in meat and supplements and derived from symbionts, on the major transitions of disease and fertility from ancient times up to the present day. A key role for the tryptophan – NAD ‘de novo’ and immune tolerance pathway are discussed at length in the context of fertility and longevity and the transitions from immune paresis to Treg-mediated immune tolerance and then finally to intolerance and their associated diseases. Abstract: Nicotinamide in human evolution increased cognitive power in a positive feedback loop originally involving hunting. As the precursor to metabolic master molecule NAD it is, as vitamin B3, vital for health. Paradoxically, a lower dose on a diverse plant then cereal-based diet fuelled population booms from the Mesolithic onwards, by upping immune tolerance of the foetus. Increased tolerance of risky symbionts, whether in the gut or TB, that excrete nicotinamide co-evolved as buffers for when diet was inadequate. High biological fertility, despite disease trade-offs, avoided the extinction of Homo sapiens and heralded the dawn of a conscious, creative, and pro-fertility culture. Nicotinamide equity now would stabilise populations and prevent NAD-based diseases of poverty and affluence

A behavioural ecology approach to understand volunteer surveying for citizen science datasets

Among other outcomes, volunteer surveys are useful for evaluating conservation success and determining priorities for management actions. However, biases that can originate from untargeted and weakly structured surveys can undermine the utility of the data gathered. Identifying and rectifying biases and problems with such data require an understanding of the behaviour of volunteers. We explored the characteristics of volunteer behaviour using bird surveys conducted in south-western Australia, and evaluated how volunteer behaviour affects the quantity and quality of data when volunteers are unconstrained in their selection of survey sites. We related the home-range and site-fidelity of 172 volunteers to the availability of habitat and bird species. Habitat selection by volunteers was assessed using avian species-accumulation curves, which identified 12 habitats for which avian species inventories wer

Count data models for demographic data.

Key demographic variables, such as the number of children and the number of marriages or divorces, can only take integer values. This papers deals with the estimation of single equation models in which the counts are regressed on a set of observed individual characteristics such as age, gender, or nationality. Most empirical work in population economics has neglected the fact that the dependent variable is a nonnegative integer. In the few cases where this feature was recognized, the authors advocated the use of the Poisson regression model. The Poisson model imposes, however, the equality of conditional mean and variance, a restriction which is often rejected by the data. We propose a generalized event count model to simultaneously allow for a wide class of count data models and account for over- and underdispersion. This model is successfully applied to German data on fertility, divorces and mobility