Glycosaminoglycan accumulation with partial deficiency of β-glucuronidase in the C3H strain of mice

Young (60–80 days) mice of the low β-glucuronidase strain, C3H/HeJ, showed no differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the randombred, “normal” Swiss-Webster mice of the same age. However, by 12 months of age hepatic GAG is nearly twice as high in C3H/HeJ mice as in Swiss-Webster mice. Studies of β-glucuronidase, β-galactosidase, and N -acetyl-β-glucosaminidase in four tissues of the two types of mice at the two ages revealed that glucuronidase was the only enzyme with lower activity in the C3H/HeJ strain.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44128/1/10528_2004_Article_BF00484528.pd