Electrochemical Oxidation of Glucose Using Copper Hydroxide Nanosheets

In this study, we synthesized copper hydroxide nanosheet and investigated electrochemical oxidation of glucose using the copper hydroxide nanosheets. The precursor of the nanosheet was a layered copper hydroxide synthesized by the ion exchange of dodecylbenzene sulfonate with acetate in Cu2(OH)3(CH3COO)·H2O. Delamination of the layered copper hydroxide prepared the nanosheet by dispersion in 1-butanol. Atomic force microscopy images of the nanosheets showed lateral dimensions of ca. 2 μm with a height of ca. 4.5 nm. Cyclic voltammogram of the nanosheet coated electrode showed oxidation current peak depend on the concentration of glucose at around +0.6 V vs. Ag/AgCl. Amperometry was measured at +0.6V vs. Ag/AgCl with successive addition of glucose solution. Glucose concentration and catalytic current were almost proportional. When the linear range is 0.1 to 4.9 mM, the sensitivity was 1.16 mA mM-1cm-2 from the slope

SYNTHESES AND PROPERTIES OF COPPER HYDROXIDE NANOSHEETS AND CONTROLLED DEPOSITION

In this study, we synthesized copper hydroxide nanosheet and investigated its electrochemical property and how to deposit it with a uniform amount. The precursor of the nanosheet was a layered copper hydroxide synthesized by the ion exchange of dodecylbenzene sulfonate with acetate in Cu2(OH)3(CH3COO)·H2O. The nanosheet was prepared by delamination of the layered copper hydroxide by dispersion in 1-butanol. Atomic force microscopy images of the nanosheets showed lateral dimensions of ca. 2 μm with the height of ca. 4.5 nm. Cyclic voltammogram of the nanosheet in basic solution showed two cathodic peaks and two anodic peaks similar to copper oxide electrode. To deposit the nanosheet, a quartz glass slide was dipped in the dispersion of the nanosheet in 1-butanol and dried after washing. This procedure was repeated and the ultraviolet and visible light absorption spectrum of the slide was measured. The absorbance of the slide increased in direct proportion to the number of times of the dip-and-dry procedure. Thus we confirmed that controlled amount of nanosheet was deposited on the quartz glass

ジンコウ セイタイマク ノ ソフト ナノ テクノロジー

Soft nanotechnology is technology that treats soft and wet materials such as self-assembly systems in a living body under a relatively moderate condition. We focus our attention on the size control of liposomes, namely lipid bilayer membranes and performed the soft nanotechnology in sizing of liposomes under high pressure. Two high-pressure sizing techniques, a method of continuous pressure relaxation using a phase transition between gel and liquid crystalline phases of the bilayer membrane and that of a pressure-induced gel phase using a phase transition between bilayer and nonbilayer membranes, were applied to liposomes of distearoylphosphatidylcholine, and the effects of the both methods were considered. Further, the application of giant liposomes controlled by high-pressure sizing to microsensor was briefly described

Non-stick syringe needles : Beneficial effects of thin film metallic glass coating

This paper reports on the use of Zr-based (Zr53Cu33Al9Ta5) thin film metallic glass (TFMG) for the coating of syringe needles and compares the results with those obtained using titanium nitride and pure titanium coatings. TFMG coatings were shown to reduce insertion forces by ∼66% and retraction forces by ∼72%, when tested using polyurethane rubber block. The benefits of TFMG-coated needles were also observed when tested using muscle tissue from pigs. In nano-scratch tests, the TFMG coatings achieved a coefficient of friction (COF) of just ∼0.05, which is about one order of magnitude lower than those of other coatings. Finite-element modeling also indicates a significant reduction in injection and retraction forces. The COF can be attributed to the absence of grain boundaries in the TFMG coating as well as a smooth surface morphology and low surface free energy

Improvement of Accuracy in Flow Immunosensor System by Introduction of Poly-2-[3-(methacryloylamino)propylammonio]ethyl 3-aminopropyl Phosphate

In order to improve the accuracy of immunosensor systems, poly-2-[3-(methacryloylamino)propylammonio]ethyl 3-aminopropyl phosphate (poly-3MAm3AP), which includes both phosphorylcholine and amino groups, was synthesized and applied to the preparation of antibody-immobilized beads. Acting as an antibody-immobilizing material, poly-3MAm3AP is expected to significantly lower nonspecific adsorption due to the presence of the phosphorylcholine group and recognize large numbers of analytes due to the increase in antibody-immobilizing sites. The elimination of nonspecific adsorption was compared between the formation of a blocking layer on antibody-immobilized beads and the introduction of a material to combine antibody with beads. Determination with specific and nonspecific antibodies was then investigated for the estimation of signal-to-noise ratio. Signal intensities with superior signal-to-noise ratios were obtained when poly-3MAm3AP was introduced. This may be due to the increase in antibody-immobilizing sites and the extended space for antigen-antibody interaction resulting from the electrostatic repulsion of poly-3MAm3AP. Thus, the application of poly-3MAm3AP coatings to immunoassay beads was able to improve the accuracy of flow immunosensor systems

コウダイイン レンケイ カガク ジッケン ノ ケイゾク ジッシ ニヨル カイゼン ト タイケン イベント エノ カツヨウ

工学部の学部生・院生への創造教育と高大連携の同時実現を目的として高大院連携出張講義を実施し，教えることによる学びを活用した効果的な教育法を検討した。継続的に実施してきた高校への化学実験出張講義を学部生・院生のティーチングアシスタントが主体となって実施した。学生同士の知識や技術の伝達により，高大院連携化学実験の実施方法の改善が認められ，今後の課題も明らかとなった。また，この出張講義で指導した学生と受講した高校生の一部が小中学生や一般対象の化学展にブースを出展し，成果の活用を試みた。イベント出展の実施により，高大院連携が初等教育や科学リテラシーなどの地域貢献としても有用であることが示された