EXPERIMENTAL STUDIES ON A NEW ANTI-INFLAMMATORY AGENT OF NON-STEROID GROUP, “DA-398”, AND ITS CLINICAL EXPERIENCES IN ORAL SURGERY

The effect of DA-398, a new anti-inflammatory agent of the non-steroid group, on carrageenin-induced edema was examined experimentally, and its inhibitory effect on rats, weighing 120-140 g, by administration of 30 to 50 mg/kg was recognized. The clinical effect of this drug on inflammatory and postoperative cases in oral surgery was estimated, dividing the 70 subjects into five groups whose members were administered 150-600 mg of DA-398 or placebo. It was thereby found that a daily administration of more than 300 mg would be clinically effective. As side effects produced by DA-398, some slight symptoms like stomachache and nausea were found in 4 cases (7.3%) out of the total 55 cases