Menstrual Abnormalities in Female International Students in Japan : Changes during Pre-Arrival, Difficult, and Current Periods

The number of Japan’s international students has rapidly increased in the last decade. This study examines the relationship between menstrual abnormalities in cycle and symptoms, stress level, and lifestyle of female international students in Japan across three time periods, namely pre-arrival, difficult, and current time periods. A cross-sectional design was employed, and data were collected through a self-administered questionnaire, including the menstrual distress questionnaire (MDQ), between December 2022 and February 2023. The questionnaire was distributed to 56 female international students from two universities in Japan, and a total of 29 valid responses were collected. We found varying menstrual cycle abnormalities and severity of menstrual symptoms across three time periods, with the difficult period after arrival in Japan displaying the highest symptom severity. Higher stress levels were significantly associated with more severe menstrual symptoms. Lifestyle habits such as alcohol consumption were also linked to menstrual symptoms. The current study emphasizes the importance of providing menstrual education, support, and resources to address international students’ unique challenges in managing their menstrual health while studying abroad. By promoting awareness, education, and access to healthcare services, universities may contribute to international students’ well-being and academic success

産後6か月間におけるうつ・不安症状の経過と新生児と関わる時の感情との関連

Background: Depressive symptoms and anxiety symptoms during the postpartum period affect physical health and child rearing and that these effects are important social issues. Objective: The aims of this study were to clarify the differences in the transition of depressive symptoms and anxiety symptoms according to parity during a 6-month postpartum period and to clarify the differences in associations of depressive symptoms and anxiety symptoms with feelings for involvement with newborn infants in primiparous and multiparous postpartum women. Methods: The design of this study was a longitudinal investigation. This study was conducted from February 2017 to July 2018 in Japan. By using self-administered questionnaires that included questions on psychological symptoms in a standard climacteric scale and questions on feelings for involvement with newborn infants, we collected data at 3 days postpartum, 2 weeks postpartum, one month postpartum, 3 months postpartum and 6 months postpartum. Results: Responses to all of the questionnaires were obtained from 121 (52.8%) of 229 women. The score for depressive symptoms in primiparous women was significantly higher than that in multiparous women at 3 days postpartum. Depressive symptoms and anxiety symptoms showed peaks at 2 weeks postpartum in both primiparous women and multiparous women, but depressive symptoms reoccurred from 3 months postpartum to 6 months postpartum in primiparous women and anxiety symptoms reoccurred from one month to 3 months postpartum in multiparous women. Depressive symptoms and anxiety symptoms were associated with negative feelings for involvement with newborn infants and with mother’s sleeping time. Conclusion: Changes in depressive symptoms and anxiety symptoms were different in primiparous women and multiparous women during a 6-month postpartum period. In addition, depressive symptoms and anxiety symptoms were associated with negative feelings for involvement with newborn infants and with sleeping time in postpartum women

Prevalence and factors related to hot flashes and night sweats in postpartum women in Japan

Hot flashes and night sweats commonly occur during menopausal transition period due to estrogen deficiency, but these conditions can also occur during postpartum period in which there are marked hormonal fluctuations. This study determined the prevalence and examined factors related to hot flashes and night sweats among the Japanese women in the postpartum period. The design of this study was a longitudinal investigation and the population of the postpartum women recruited was 229. A self-administered questionnaire that adapted Edinburgh Postnatal Depression Scale (EPDS) of measurement was used to collect data at 3 days postpartum, 2 weeks postpartum and one month postpartum. There was a significant association between transient night sweats and anxiety regarding family finances. Women who complained of hot flashes was 22.8% at 3 days postpartum and it decreased thereafter, while women who complained of night sweats were 58.6% at 3 days postpartum, 33.1% at 2 weeks postpartum and 15.2% at one month postpartum. In conclusion, hot flashes and night sweats among Japanese women in the postpartum period was associated with psychological and social factors

Cognitive dysfunction and amyloid β accumulation are ameliorated by the ingestion of green soybean extract in aged mice

AbstractThe effects of soybean extracts were investigated in senescence-accelerated (SAMP10) mice, a mouse model of brain senescence with cognitive dysfunction. Mature soybeans are usually yellow. However, the green soybean retains green color after being ripened. Cognitive functions were significantly better-preserved in aged mice fed green soybean than age-matched control mice with or without yellow soybean feeding. Molecular mechanisms of the beneficial effect of green soybean on brain functions were examined through transcriptome analysis of SAMP10 hippocampus. The high expression of Ptgds was significantly associated with green soybean diet, which encodes lipocalin-type prostaglandin D2 synthase, a putative endogenous amyloid β(Αβ)-chaperone. In consonance, Aplp1 expression was significantly reduced, a member of amyloid precursor proteins. Furthermore, the amount of Aβ 40 and 42 was reduced in the insoluble fraction of cerebral cortex. These results suggest that the intake of green soybean ameliorates cognitive dysfunction of aged mice through the reduction of Aβ accumulation

A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB.

The majority of supratentorial ependymomas (ST-ependymomas) have few mutations but frequently display chromothripsis of chromosome 11q that generates a fusion between C11orf95 and RELA (RELAFUS). Neural stem cells transduced with RELAFUSex vivo form ependymomas when implanted in the brain. These tumors display enhanced NF-κB signaling, suggesting that this aberrant signal is the principal mechanism of oncogenesis. However, it is not known whether RELAFUS is sufficient to drive de novo ependymoma tumorigenesis in the brain and, if so, whether these tumors also arise from neural stem cells. We show that RELAFUS drives ST-ependymoma formation from periventricular neural stem cells in mice and that RELAFUS-induced tumorigenesis is likely dependent on a series of cell signaling pathways in addition to NF-κB

2種のβ-キシロシダーゼによるキシロースの縮合反応の比較

The kinetic characterization of two fungal (Aspergillus niger and Malbranchea pulchella) β-xylosidases reveals "product specificity" in the condensation reaction of xylose. The specificity of xylodisaccharide production in the condensation reaction yields more variation for the M. pulchella enzyme than for the A. niger one. Of the products, β-1,4-xylodisac-charide is produced most in the reaction of both enzymes. A simple mechanism with forward (condensation) and reverse (hydrolysis) reactions is assumed and the rate constants for the forward reactions of the respective β-linked xylodisaccharides are experimentally determined as well as the equilibrium constants. The rate constants for the reverse reactions are estimated from these equilibrium and rate constants, and found to have smaller values than those observed in the initial velocities of the hydrolysis, inferring inhibition of the reaction with a high concentration of xylose. Comparison of the actual time course in xylodisaccharide production with that obtained by a computer simulation for this simple mechanism implies that the reaction mechanism of the M. pulchella enzyme comprises the condensation and hydrolysis reactions, while the mechanism of the A. niger enzyme further includes the reaction producing xylotrisaccharide

Associations of psychological status in the early postpartum period with resumption of menstruation and degree of menstruation-related symptoms

The aim of this prospective study was to clarify the associations of psychological status in the early postpartum period with resumption of menstruation and degree of menstruation-related symptoms. This study was conducted from February in 2017 to July in 2018 in Japan. We conducted self-administered questionnaire surveys for 229 postpartum women at 3 days postpartum, 2 weeks postpartum, one month postpartum, 3 months postpartum and 6 months postpartum. The proportion of women who resumed menstruation in the period up to 6 months postpartum was 38.8%. The Edinburgh Postnatal Depression Scale (EPDS) score at 6 months postpartum in women who resumed menstruation in the period up to 6 months postpartum was significantly higher than that in women who did not resume menstruation. EPDS scores during the postpartum period in women in whom menstruation-related symptoms became worse than those before pregnancy were significantly higher than those in women in whom menstruation-related symptoms did not change compared to those before pregnancy. In multiple regression analysis, there was no significant difference between EPDS score at 6 months postpartum and degree of menstruation-related symptoms. Additional research is needed to clarify the association of psychological condition during the postpartum period with resumption of menstruation. Impact Statement What is already known on this subject? Postpartum psychological symptoms such as depression and anxiety during the postpartum period may affect degrees of menstruation-related symptoms after resumption of menstruation, and there also may be a bidirectional relationship between psychological symptoms and menstrual pain. What do the results of this study add? Resumption of menstruation occurred in 38.8% of 121 women within 6 months postpartum, and poor psychological condition during the postpartum period was associated with early resumption of menstruation. The psychological condition in women with earlier resumption of menstruation might affect menstruation-related symptoms. What are the implications of these findings for clinical practice and/or further research? Management of a stable psychological status during the early postpartum period should be implemented for women's health care in the future