Strategies of Dengue Vaccine Development by W. H. O. Using New Biotechnology

Dengue fever and dengue haemorrhagic fever (DHF) with shock syndrome are found in tropical and subtropical areas of Asia, Africa, Western Pacific and Central and South America. DHF is one of the major causes of hospitalization of children in urban of these areas. Control of the mosquito is the only means available now to curb the disease. Therefore a vaccine is urgently needed. Sequential infections with different dengue virus serotypes represent a risk factor for DHF. Prior immunity to a heterologus serotype enhance virus infection of another serotype in macrophages and monocytes. Thus, the approach of the Steering Committee (SC) of W. H. O. is to develop a tetravalent candidate vaccine including 4 serotype antigens or to engineer dengue vaccines without the component of immune-mediated enhancement. The strategic plan of the SC had included (a) definition of protective epitopes; (b) expression of protective epitopes; (c) definition of virulence in molecular terms. In view of the fruits, the following strategic plans of the SC were included. i. Infectious clone research using parental and candidate vaccine strains and definition of virulence and attenuation in molecular terms. ii. Construction and expression of protective immunogens by genetic engineering techniques. iii. Development of animal model for DHF. iv. Development of candidate vaccines

Decoding Motor Control Mechanisms Underlying Adaptive and Versatile Locomotion in Centipedes

要約のみTohoku University石黒章夫課

Deep CO Observations and the CO-to-H_2 Conversion Factor in DDO 154, a Low Metallicity Dwarf Irregular Galaxy

We present a deep spectroscopic search for CO emission in the dwarf irregular galaxy DDO154, which has an Oxygen abundance of only 1/20 the solar value. The observations were conducted in order to constrain the CO-to-$\mathrm{H_2}$ conversion factor at low metallicity. No CO was detected, however, despite being one of the sensitive observations done towards galaxies of this type. We succeed in putting a strong lower limit on the conversion factor, at least 10 times the Galactic value. Our result supports previous studies which argue for a high conversion factor at low metallicity.Comment: 11 pages, 4 figures. Accepted for publication in PAS

Hepatic infarction following abdominal interventional procedures.

To clarify the incidence, background, and progress of hepatic infarction following interventional procedures, cases of hepatic infarction following interventional procedures at our department during the last decade were identified by reviewing the clinical records of 1982 abdominal angiography and interventional procedures and records of abdominal CT. Nine episodes (0.5%) in 8 patients were identified as hepatic infarction following an interventional procedure. Five episodes were preceded by embolization of the hepatic or celiac artery at emergency angiography for postoperative bleeding with hemorrhagic shock. Three episodes followed the elected interventional procedure for hepatocellular carcinoma, and the remaining episode occurred after 12 months of chemoinfusion through an indwelling catheter in the hepatic artery and portal vein. Hepatic arterial occlusion in all episodes and portal venous flow abnormality in 5 episodes were observed on angiography. Four patients whose liver function was initially impaired died of hepatic infarction, although the extent of the disease on CT did not appear to be related to the mortality. Multiple risk factors, including arterial insufficiency, were observed in each patient. The incidence of hepatic infarction following interventional procedures in this series was low but sometimes fatal, and occurred most frequently in emergency embolization in hemorrhagic shock.</p

Exploring common control principles underlying versatile body−limb coordination in many-legged locomotion

The 11th International Symposium on Adaptive Motion of Animals and Machines. Kobe University, Japan. 2023-06-06/09. Adaptive Motion of Animals and Machines Organizing Committee.Poster Session P

An agent-based model of the interrelation between the COVID-19 outbreak and economic activities

As of July 2020, COVID-19 caused by SARS-COV-2 is spreading worldwide, causing severe economic damage. While minimizing human contact is effective in managing outbreaks, it causes severe economic losses. Strategies to solve this dilemma by considering the interrelation between the spread of the virus and economic activities are urgently needed to mitigate the health and economic damage. Here, we propose an abstract agent-based model of the COVID-19 outbreak that accounts for economic activities. The computational simulation of the model recapitulates the trade-off between the health and economic damage associated with voluntary restraint measures. Based on the simulation results, we discuss how the macroscopic dynamics of infection and economics emerge from individuals’ behaviours. We believe our model can serve as a platform for discussing solutions to the above-mentioned dilemma

Effects of radiofrequency ablation on individual renal function: assessment by technetium-99m mercaptoacetyltriglycine renal scintigraphy.

We quantitatively evaluated total and individual renal function by technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renal scintigraphy before and after radiofrequency ablation (RFA) of renal tumors. Eleven patients who underwent Tc-99m MAG3 renal scintigraphy 1 week before and after RFA were evaluated (7 men and 4 women ; age range : 23-83 years ; mean age : 60.6 years). Five patients had solitary kidneys, and five had normally or minimally functioning contralateral kidneys. One patient had a renal cell carcinoma in the contralateral kidney. One patient with a solitary kidney underwent RFA a second time for a residual tumor. In patients with a solitary kidney, MAG3 clearance decreased after 5 of 6 RFAs, and in patients with a normally functioning contralateral kidney, MAG3 clearance decreased after 4 of 5 RFAs, but no significant differences were observed between before and after treatments. In addition to the total MAG3 clearance, the split MAG3 clearance was evaluated in patients with a normally functioning contralateral kidney. MAG3 clearance decreased in 4 of 5 treated kidneys, while it adversely increased in the contralateral kidneys after 4 of 5 RFAs. No significant differences, however, were observed between before and after treatments. The results of our study revealed no significant differences in sCr, BUN, CCr, or MAG3 clearance between pre- and post-RFA values. These results support data regarding the functional impact and safety of renal RFA in published reports. We evaluated total and individual renal function quantitatively using Tc-99m MAG3 renal scintigraphy before and after treatment. This scintigraphy was very useful in assessing the effects of RFA on renal function