Characterized divertor footprint profile modification with the edge pressure gradient in the Large Helical Device

The first attempt to characterize the divertor footprint profile in the heliotron device LHD was done, by using a number of Langmuir probes and the multivariable analysis technique. In order to clarify the generation mechanism of the private-side peak on the footprint profile, which has not been reproduced in the modeling study, over 6000 time points were extracted by excluding time points with profile modifications due to already-known reasons. A characterization index ${r}_{2/1}$ was newly defined from the multivariable analysis result, and its dependences on upstream parameters were investigated. As a result, it was found that the footprint profile correlates with the pressure gradient at the edge inside the core region with a fixed beta, suggesting that change of the plasma pressure profile could modify the edge magnetic field structure even if the volume integral of the plasma pressure was constant

高ベータプラズマ運転領域の低衝突性領域への拡大, 高ベータプラズマ運転領域の低衝突性領域への拡大

In the large helical device, plasma with more than 4% average beta was successfully produced by multi-pellet injections in a regime with a collisionality one order of magnitude lower than that in previous high-beta operations. An improvement in particle confinement was observed during a high-beta discharge produced by a gas puff, and particle flux to the divertor was reduced by more than 40%. High instabilities at the plasma edge occurred and suppressed the increment of the average beta to 3.4%. A spontaneous change in the magnetic topology contributes to an increase in the average beta value while triggering the excitation of edge MHD instabilities

Simultaneous excitation of the snake-like oscillations and the m/n = 1/1 resistive interchange modes around the iota = 1 rational surface just after hydrogen pellet injections in LHD plasmas

Two types of oscillation phenomena are found just after hydrogen ice pellet injections in the Large Helical Device (LHD). Oscillation phenomena appear when the deposition profile of a hydrogen ice pellet is localized around the rotational transform ι = 1 rational surface. At first, damping oscillations (type-I) appear only in the soft X-ray (SX) emission. They are followed by the second type of oscillations (type-II) where the magnetic fluctuations and density fluctuations synchronized to the SX fluctuations are observed. Both oscillations have poloidal/toroidal mode number, m/n = 1/1. Since the type-II oscillations appear when the local pressure is large and/or the local magnetic Reynold\u27s number is small, it is reasonable that type-II oscillations are caused by the resistive interchange modes. Because both types of oscillations appear simultaneously at slightly different locations and with slightly different frequencies, it is certain that type-I oscillations are different from type-II oscillations, which we believe is the MHD instability. It is possible that type-I oscillations are caused by the asymmetric concentration of the impurities. The type-I oscillations are similar to the impurity snake phenomena observed in tokamaks though type-I oscillations survive only several tens of milliseconds in LHD

Effects of Resonant Magnetic Perturbation on Particle Transport in LHD

In this study, the effects of resonant magnetic perturbation (RMP) on particle transport are investigated in Large Helical device (LHD). The magnetic configuration is selected to be the outwardly shifted configuration, for which the magnetic axis position (Rax) is 3.9 m. At Rax = 3.9 m, the main plasma is surrounded by a thick ergodic layer, with width of about 30% of the plasma minor radius. The perturbation mode m/n = 1/1, where m and n are poloidal and toroidal mode numbers, is applied. The resonant layer is around the last closed flux surface. With RMP, a region in which both the connection and Kolmogorov lengths are finite and the magnetic field is ergodic forms; this region extends inside the main plasma. In the low-collisionality regime, where νh* 1), a clear difference in particle transport is found. A clear difference in turbulence is also observed, suggesting that turbulence plays a significant role in particle transport in the high-collisionality regime both with and without RMP

Recent results from deuterium experiments on the large helical device and their contribution to fusion reactor development

In recent deuterium experiments on the large helical device (LHD), we succeeded in expanding the temperature domain to higher regions for both electron and ion temperatures. Suppression of the energetic particle driven resistive interchange mode (EIC) by a moderate electron temperature increase is a key technique to extend the high temperature domain of LHD plasmas. We found a clear isotope effect in the formation of the internal transport barrier in high temperature plasmas. A new technique to measure the hydrogen isotope fraction was developed in the LHD in order to investigate the behavior of the isotope mixing state. The technique revealed that the non-mixing and the mixing states of hydrogen isotopes can be realized in plasmas. In deuterium plasmas, we also succeeded in simultaneously realizing the formation of the edge transport barrier (ETB) and the divertor detachment. It is found that resonant magnetic perturbation plays an important role in the simultaneous formation of the ETB and the detachment. Contributions to fusion reactor development from the engineering point of view, i.e. negative-ion based neutral beam injector research and the mass balance study of tritium, are also discussed

Recent Results from LHD Experiment with Emphasis on Relation to Theory from Experimentalist’s View

he Large Helical Device (LHD) has been extending an operational regime of net-current free plasmas towardsthe fusion relevant condition with taking advantage of a net current-free heliotron concept and employing a superconducting coil system. Heating capability has exceeded 10 MW and the central ion and electron temperatureshave reached 7 and 10 keV, respectively. The maximum value of β and pulse length have been extended to 3.2% and 150 s, respectively. Many encouraging physical findings have been obtained. Topics from recent experiments, which should be emphasized from the aspect of theoretical approaches, are reviewed. Those are (1) Prominent features in the inward shifted configuration, i.e., mitigation of an ideal interchange mode in the configuration with magnetic hill, and confinement improvement due to suppression of both anomalous and neoclassical transport, (2) Demonstration ofbifurcation of radial electric field and associated formation of an internal transport barrier, and (3) Dynamics of magnetic islands and clarification of the role of separatrix

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

Impact of Magnetic Field Configuration on Heat Transport in Stellarators and Heliotrons

We assess the magnetic field configuration in modern fusion devices by comparing experiments with the same heating power, between a stellarator and a heliotron. The key role of turbulence is evident in the optimized stellarator, while neoclassical processes largely determine the transport in the heliotron device. Gyrokinetic simulations elucidate the underlying mechanisms promoting stronger ion scale turbulence in the stellarator. Similar plasma performances in these experiments suggests that neoclassical and turbulent transport should both be optimized in next step reactor designs