Solitary Asymptomatic Thyroid Metastasis from Hepatocellular Carcinoma Detected by FDG-PET/CT

Thyroid metastases from hepatocellular carcinoma (HCC) seldom occur and are often difficult to diagnose because of their asymptomatic clinical course. We evaluated a very rare case of solitary thyroid metastasis from HCC that showed high uptake of fluorine-18 fluorodeoxyglucose (FDG), when imaged using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). The patient was a 74-year-old man and presented with a remarkably elevated des-gamma-carboxy prothrombin level of 1,157 mAU/ml 22 months after hepatic lobectomy. FDG-PET/CT imaging revealed a hypodense tumor with high FDG uptake, with a maximum standardized uptake value of 5.2 in the thyroid left lobe. Solitary thyroid metastasis from HCC was suspected and subsequent fine needle aspiration did indeed reveal HCC. The patient received left thyroidectomy with left regional lymph node dissection. Two months after left thyroidectomy, contrast-enhanced computed tomography showed local recurrence, and the patient received ongoing radiotherapy treatment. To our knowledge, the present study is the first to demonstrate the feasibility of FDG-PET/CT in the diagnosis and management of clinically diagnosed, asymptomatic, solitary thyroid metastasis from HCC

Effect of Active Screen Plasma Nitriding on Mechanical Properties of Spheroidal Graphite Cast Iron

Spheroidal graphite cast iron is a material with a wide range of uses such as in automobile parts. By applying active screen plasma nitriding (ASPN) treatment, the use of spheroidal graphite cast iron is expanded, and it can be expected to be used under special load conditions. In this study, we evaluated the effect of ASPN treatment on the mechanical properties of spheroidal graphite cast iron. With ASPN treatment, a nitride layer was formed on the sample surface and a diffusion layer was formed further inside the nitride layer. The thickness of nitride layer increased as the treatment temperature increased. The hardness was improved by ASPN treatment. The abrasion resistance was improved by ASPN treatment, and longer treatment time resulted in higher abrasion resistance. The fatigue strength was improved by ASPN treatment, and longer treatment time resulted in higher fatigue strength. ASPN treatment also improved the corrosion resistance

Effect of Active Screen Plasma Nitriding on Mechanical Properties of Spheroidal Graphite Cast Iron

Spheroidal graphite cast iron is a material with a wide range of uses such as in automobile parts. By applying active screen plasma nitriding (ASPN) treatment, the use of spheroidal graphite cast iron is expanded, and it can be expected to be used under special load conditions. In this study, we evaluated the effect of ASPN treatment on the mechanical properties of spheroidal graphite cast iron. With ASPN treatment, a nitride layer was formed on the sample surface and a diffusion layer was formed further inside the nitride layer. The thickness of nitride layer increased as the treatment temperature increased. The hardness was improved by ASPN treatment. The abrasion resistance was improved by ASPN treatment, and longer treatment time resulted in higher abrasion resistance. The fatigue strength was improved by ASPN treatment, and longer treatment time resulted in higher fatigue strength. ASPN treatment also improved the corrosion resistance

Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts

Background: Interleukin (IL)-4 and IL-13, which play a role in the production of allergic inflammation, can activate fibroblasts to elicit a variety of cellular functions. However, the effect of IL-4 and IL-13 on fibronectin production by human lung fibroblasts (HLF) has not been determined. In the present study, we examined the effect of IL-4 and IL-13 on fibronectin production by HLF in order to clarify these issues. Methods: We stimulated HLF with various concentrations of IL-4 and IL-13 for 12, 24, 48 and 72 h and fibronectin concentrations in the culture supernatants were determined by ELISA Results: The results showed that IL-4 and IL-13 induced fibronectin production in a time- and a concentration-dependent manner. Anti-transforming growth factor (TGF)β1 antibody (ab) inhibited TGF-β1 induced fibronectin production but not IL-4- and IL-1 3-induced fibronectin production, indicating that TGF-β1 is not involved in the IL-4- and IL-13-induced fibronectin production by HLF. Conclusions: These results indicate that IL-4 and IL-13 are capable of inducing fibronectin production by HLF and play an important role in the production of airway remodeling by inducing fibronectin production as well as allergic inflammation

Effects of Perioperative Oral Management in Patients with Cancer

Perioperative oral management (POM) is used to prevent pneumonia in patients with cancer. However, the factors that expose hospitalized patients to increased risk of developing pneumonia remain unclear. For example, no study to date has compared the incidence of pneumonia in hospitalized patients by cancer primary lesion, or POM implementation, or not. We determined which patients were most likely to benefit from POM and examined the effects of POM on pneumonia prevention and mortality. In a total of 9441 patients with cancer who underwent surgery during hospitalization, there were 8208 patients in the No POM group, and 1233 in the POM group. We examined between-group differences in the incidence of pneumonia and associated outcomes during hospitalization. There was no significant between-group difference in the incidence of pneumonitis, however, patients with lung, or head and neck cancers, demonstrated a lower incidence of postoperative pneumonia. Among patients with lung and pancreatic cancers, mortality was significantly lower in the POM group. POM appears effective at reducing the risk of postoperative pneumonia in patients with certain cancers. Further, mortality was significantly lower in patients with lung and pancreatic cancers who received POM; hence, POM may be an effective adjuvant therapy for patients with cancer