Distribution and chromosomal diversity of Thai-medaka, Oryzias minutillus in Thailand

Article信州大学理学部附属諏訪臨湖実験所報告 9: 137-147(1995)departmental bulletin pape

Studies of Biology Conducted for Genertions by the Imperial Family of Japan

東京海洋大学名誉教

ゴマフエダイ仔稚魚の摂餌・遊泳機能の発達

東京水産大学東京水産大学東京水産大学東京水産大

A quantum isomonodromy equation and its application to N=2 SU(N) gauge theories

We give an explicit differential equation which is expected to determine the instanton partition function in the presence of the full surface operator in N=2 SU(N) gauge theory. The differential equation arises as a quantization of a certain Hamiltonian system of isomonodromy type discovered by Fuji, Suzuki and Tsuda.Comment: 15 pages, v2: typos corrected and references added, v3: discussion, appendix and references adde

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Geographic Distribution of Primary Freshwater Fishes in Four Principal Areas of Southeast Asia

この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。Analysis of the primary freshwater fish faunas of the four principal areas of Southeast Asia shows that 1) the fauna of the Irrawaddy-Salwin basins, while including endemic forms, is as a whole intermediate between th faunas of India and the Indosinian district, 2) the faunas of the Greater Sunda Islands and the Mekong-Chao Phya basins have a close resemblance, but rather many mainland genera do not occur on the islands and some endemic forms are found in each the area, and 3) the fauna of the Song-Koi basin is similar to that of southern China and distinct from those of other part of Southeast Asia. In the cyprinid fishes there are several groups which differ in the evolutionary history and pattern of dispersal. Their ancestral stock may have been well established geographically in main part of Southeast Asia during the early Tertiary. The sharp boundary separating the Chinese and the Indo-Indosinian subregions suggests the former existence of a certain effective and long-lasting barrier extending from the Bay of Tonkin nearly to Yunnan

The larval and juvenile fish community in Pandan Bay, Panay Island, Philippines

Long-term (1975-1977) collections of larval and juvelnile fish were made from 1) onshore, a sandy beach flanked by a coral terrace and a river mouth, and 2) 500m offshore in 30 m deep water in Pandan Bay. About 70 species in 47 families were recorded onshore and 120 specis in 74 families were recorded offshore over the two-year period. About 60 species were common to both stations. Metamorphic stage Mugilidae dominated the onshore catch (75% of 587 samples), followed by Ambassis ssp. (55%) and Chanos chanos (48%). Predominant in the offshore station were larval Stolephorus spp. and Sardinella spp., occurring in 79% and 62% of 345 samples, respectively. Apogonidae, Leiognathidae, Gobiidae, Dussumieria sp., Caesio spp., Upeneus spp. larval, and the neotenic fish, Schindleria praematura, each occured in 20-40% of the offshore samples. Siganus spp., Lutjanus spp., Sphyraena spp. occured in considerable numbers onshore. Offshore, the first two species occured in higher, and the latter two in lower relative abundance. Mugilidae and Chanos chanos were also relatively less abundant offshore. Larvae of many inshore and pelagic fishery species like Carangidae, Scombridae and Bothidae occured at the offshore station together with larvae of coral reefs species like Pomacentrus spp. and the mesopelagic species like Benthosema spp. and Lestidiops sp