Enhanced metabolism of phosphatidylinositol in Candida tropicalis in association with filamentous growth caused by ethanol

AbstractCandida tropicalis Pk 233 grows in filamentous form in ethanol-supplemented medium, and myo-inositol prevents the ethanol ettect [(1979) Bioch!em. Biophys. Res. Commun. 91, 351–355]. Cells, which were grown with ethanol to the log phase, exhibited an increased rate of phosphatidylinositol turnover as judged by pulse-chase experiments with 32Pi. Such enhanced metabolism of phosphatidylinositol was not observed in fully developed filamentous cells at the stationary phase or in yeast-like cells which were grown without added ethanol or with ethanol plus myo-inositol. The metabolism of other phospholipids was not affected by ethanol