The teacher's readiness to interact with gifted students

In the article, the authors consider the problem of a teacher's readiness to interact with gifted students in the process of their continuous development. In modern Russian society, there is a growing need for people who are extraordinarily thinking, creative, active, capable of solving tasks in an unconventional way and formulating new, promising goals. In these conditions, the support and development of gifted students undoubtedly become one of the priority tasks of the education system. The relevance of the work is due to the fact that the transition of general and vocational education to a new educational paradigm, caused by the transformations of Russian society, is accompanied by increased attention to gifted students, and as a result, by the preparation of teachers at all levels of the education system to interact with students, whose intellectual and creative potential is considered as state capital stock. The article presents the results of content analysis of scientific works in the field of the development of gifted students, as well as regulatory and legal acts of the Russian Federation in the field of education. The concept of pedagogical management is introduced (a set of approaches, principles, methods, organizational forms and technological and methodological teaching methods aimed at improving the quality and effectiveness of the continuous development of gifted students, which consists of the stages: identification, diagnosis, training, development, support and support ). As a result of the study, the authors, based on the principle of identifying the types of teacher's activities on the main stages of pedagogical management, proposed a component structure of the teacher's readiness to interact with gifted students, integrating motivational-value, cognitive-methodological, normative-organizational, reflexive-evaluative and communicative-tutoring component

Использование пробиотических препаратов для повышения продуктивных качеств в козоводстве: обзор

An analytical review of scientific publications on probiotics in goat breeding was carried out. It has been established that the most popular probiotic microorganisms in goat farming are bacteria of the species Bacillus subtilis, Bifidobacterium bifidum, Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus plantarum and single-celled yeast of the species Saccharomyces cerevisiae. Including probiotic microflora in the diet increases the number of bacteria in the rumen contents of goats. Reducing the number of Clostridia and Escherichia coli in animal faeces is achieved by replacing the native faecal microflora with streptococci and lactic acid bacteria. It has been shown that feeding probiotic preparations is accompanied by an improvement in the metabolic status in the body of goats and is expressed by an increase in the concentration of total protein and its fractions, haemoglobin, erythrocytes, macro- and microelements in the blood of animals, and optimisation of lipid metabolism. Probiotics help preserve villi and inhibit inflammation of the intestinal epithelium of animals, exhibit antimutagenic and anticarcinogenic properties, and help reduce putrescine concentration in faeces. Feeding probiotics ensures an increase in daily milk yield, fat and protein content by increasing the digestibility of diet solids, primarily crude fibre. The probiotic potential of some microorganisms is expressed in increased concentrations of unsaturated fatty acids in goat milk and meat with a decrease in the atherogenic index of raw materials. The use of drugs helps to increase the absolute increase in live weight of goat kids against the background of the harmonious development of the physique of young animals due to the production of microbial phytase, a decrease in the redox potential of chyme and an increase in the number of microorganisms that consume lactic acid. Some authors report the absence of a significant effect when using probiotics in feeding lactating animals and raising goat kids.Проведен аналитический обзор научных публикаций по вопросу использования пробиотиков в козоводстве. Установлено, что наиболее востребованными пробиотическими микроорганизмами в козоводстве являются бактерии видов Bacillus subtilis, Bifidobacterium bifidum, Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus plantarum и одноклеточные дрожжи вида Saccharomyces cerevisiae. Включение в рацион пробиотической микрофлоры приводит к увеличению количества бактерий рубцового содержимого коз. Снижение числа клостридий и Escherichia coli в фекалиях животных достигается замещением нативной фекальной микрофлоры стрептококками и молочнокислыми бактериями. Показано, что скармливание пробиотических препаратов сопровождается улучшением метаболического статуса в организме коз и выражается ростом концентрации общего белка и его фракций, гемоглобина, эритроцитов, макро- и микроэлементов в крови животных, оптимизацией липидного обмена. Пробиотики способствуют повышению сохранности ворсинок и ингибированию воспаления эпителия кишечника животных, проявляют антимутагенные и антиканцерогенные свойства, содействуют снижению концентрации путресцина в фекалиях. Скармливание пробиотиков обеспечивает увеличение суточных удоев, содержания жира и белка в молоке за счет повышения переваримости сухих веществ рациона, прежде всего, сырой клетчатки. Пробиотический потенциал некоторых видов микроорганизмов выражается в повышении концентрации в молоке и мясе коз ненасыщенных жирных кислот при снижении индекса атерогенности сырья. Применение препаратов способствует увеличению абсолютного прироста живой массы козлят на фоне гармоничного развития телосложения молодняка благодаря выработке микробиальной фитазы, снижению окислительно-восстановительного потенциала химуса и росту количества микроорганизмов–потребителей молочной кислоты. Некоторые авторы сообщают об отсутствии значимого эффекта при применении пробиотиков в кормлении лактирующих животных и при выращивании козлят

Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones

The major vault protein (MVP) mediates diverse cellular responses, including cancer cell resistance to chemotherapy and protection against inflammatory responses to Pseudomonas aeruginosa. Here, we report the use of photoactive probes to identify MVP as a target of the N-(3-oxo-dodecanoyl) homoserine lactone (C12), a quorum sensing signal of certain proteobacteria including P. aeruginosa. A treatment of normal and cancer cells with C12 or other N-acyl homoserine lactones (AHLs) results in rapid translocation of MVP into lipid raft (LR) membrane fractions. Like AHLs, inflammatory stimuli also induce LR-localization of MVP, but the C12 stimulation reprograms (functionalizes) bioactivity of the plasma membrane by recruiting death receptors, their apoptotic adaptors, and caspase-8 into LR. These functionalized membranes control AHL-induced signaling processes, in that MVP adjusts the protein kinase p38 pathway to attenuate programmed cell death. Since MVP is the structural core of large particles termed vaults, our findings suggest a mechanism in which MVP vaults act as sentinels that fine-tune inflammation-activated processes such as apoptotic signaling mediated by immunosurveillance cytokines including tumor necrosis factor-related apoptosis inducing ligand (TRAIL).Bio-organic Synthesi

Screening for a Chronic Disease: A Multiple Stage Duration Model With Partial Observability

We estimate a dynamic multistage duration model to investigate how early detection of diabetes can delay the onset of lower extremity complications and death. We allow for partial observability of the disease stage, unmeasured heterogeneity, and endogenous timing of diabetes screening. Timely diagnosis appears important. We evaluate the effectiveness of two potential policies to reduce the monetary costs of frequent screening in terms of lost longevity. Compared to the status quo, the more restrictive policy yields an implicit value for an additional year of life of about $50,000, whereas the less restrictive policy implies a value of about$120,000

Toward Accurate and Efficient Predictions of Entropy and Gibbs Free Energy of Adsorption of High Nitrogen Compounds on Carbonaceous Materials

The adsorption of high nitrogen compounds (HNCs) on the selected adsorption sites of carbonaceous materials from the gas phase has been investigated by ab initio quantum chemical methods at the density functional level applying both periodic and cluster approaches with M06-2X and BLYP functionals including dispersion forces (BLYP-D2). Among the possible structures of the adsorption complexes, the most stable systems possess nitrogen-containing heterocycles in a parallel orientation toward the modeled carbon surface. The adsorption enthalpies, calculated using the rigid rotor-harmonic oscillator approach (RRHO), were in good agreement with available experimental data. This approach was shown to provide sufficiently accurate adsorption enthalpies from the gas phase for the HNC–carbon systems. The vibrational, rotational, and translation contributions to the adsorption entropy were also analyzed by the approach extended beyond the RRHO scheme. The effects of anharmonic vibrations and internal rotations of the adsorbate on the adsorption sites of the modeled carbon surface were estimated. The Gibbs free energies calculated using the RRHO approach were adjusted to take into account the heterogeneity of the carbon surfaces and underestimation of the adsorption enthalpies at the BLYP-D2­(PBC) level. The corrected Gibbs free energy values of adsorption are negative for all of the investigated HNC–carbon systems, and they agree well with available experimental data. This suggests an effective adsorption of selected high nitrogen compounds on carbonaceous materials from the gas phase at 298.15 K. Partition coefficients for distribution of high nitrogen compounds on modeled carbon surfaces were also predicted in good agreement with the experimental results