Bicycle Safety Supplement to Teacher Buggy Driving Safety Curriculum

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Application of technologies of atomic force microscope investigation for evaluation of structure and properties of blood cells’ surfaces

With application of techniques of atomic force microscope investigation, we studied properties and topography of blood cells’ surfaces in patients with acute lymphoblastic and myeloblastic leucosis. It was stated that development of acute forms of lymphoblastic and myeloblastic types of proliferation is accompanied with reduction of stiffness of cell surface and increase of surface potentia

Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility

Inconsistent results of association studies investigated the role of glutathione S-transferase genes in idiopathic male infertility may be explained by ethnical differences in gene-gene and gene-environment interactions. In this study, we investigated a joint contribution of GSTM1, GSTT1 and GSTP1 gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian menyesBelgorod State National Research Universit

Bicycle Safety Supplement to Student Buggy Driving Safety Curriculum

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Pedestrian Safety Supplement to Student Buggy Driving Safety Curriculum

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«Digital Navigator in the World of Professions» as a Defining Vector for Conscious Professionalself-Determination of High School Students

В статье рассматривается успешный опыт организации социального партнерства, направленного на создание комплекса условий для осознанного профессионального самоопределения обучающихся городского округа Ревда, а также анонсируются перспективы совершенствования работы в данном направлении с помощью применения современных цифровых профориентационных ресурсов при реализации проекта «Цифровой навигатор в мире профессий» в рамках деятельности муниципального профориентационного Центра «ПРОФИ».The article examines the successful experience of organizing social partnerships aimed at creating a set of conditions for conscious professional self-determination of students of the Revda city district, and also announces the prospects for improving work in this direction through the use of modern digital career guidance resources in the implementation of the project «Digital Navigator in the world of Professions» within the framework of the municipal career guidance Center «PROFI»

GCIP water and energy budget synthesis (WEBS)

As part of the World Climate Research Program\u27s (WCRPs) Global Energy and Water-Cycle Experiment (GEWEX) Continental-scale International Project (GCIP), a preliminary water and energy budget synthesis (WEBS) was developed for the period 1996–1999 from the “best available” observations and models. Besides this summary paper, a companion CD-ROM with more extensive discussion, figures, tables, and raw data is available to the interested researcher from the GEWEX project office, the GAPP project office, or the first author. An updated online version of the CD-ROM is also available at http://ecpc.ucsd.edu/gcip/webs.htm/. Observations cannot adequately characterize or “close” budgets since too many fundamental processes are missing. Models that properly represent the many complicated atmospheric and near-surface interactions are also required. This preliminary synthesis therefore included a representative global general circulation model, regional climate model, and a macroscale hydrologic model as well as a global reanalysis and a regional analysis. By the qualitative agreement among the models and available observations, it did appear that we now qualitatively understand water and energy budgets of the Mississippi River Basin. However, there is still much quantitative uncertainty. In that regard, there did appear to be a clear advantage to using a regional analysis over a global analysis or a regional simulation over a global simulation to describe the Mississippi River Basin water and energy budgets. There also appeared to be some advantage to using a macroscale hydrologic model for at least the surface water budgets

Organization of logopedic work on the formation of motor sphere in the system of correction of phonetic-phonematical disabilities in children with the easy pediobulbar dizartry

The article reveals the organization of speech therapy work to eliminate speech disorders in children with a clinical diagnosis of mild pseudobulbar dysarthria, as well as offers a recital of the experiment. The urgency of the research problem is due to the fact that the number of children with speech disorders increases every year, as a result of which it is necessary to increase the effectiveness of corrective speech therapy work to eliminate speech disorders using non-traditional methods of motor development.В статье раскрывается организация логопедической работы по устранению нарушений речи у детей с клиническим диагнозом «легкая степень псевдобульбарной дизартрии», а также предлагаются материалы констатирующего эксперимента. Актуальность проблемы исследования обусловлена тем, что количество детей с речевыми нарушениями увеличивается с каждым годом, в результате чего необходимо повышение эффективности коррекционной логопедической работы по устранению нарушений речи с помощью нетрадиционных методик развития моторной сферы

Cyclic and Acyclic Defensins Inhibit Human Immunodeficiency Virus Type-1 Replication by Different Mechanisms

Defensins are antimicrobial peptides expressed by plants and animals. In mammals there are three subfamilies of defensins, distinguished by structural features: α, β and θ. Alpha and β-defensins are linear peptides with broad anti-microbial activity that are expressed by many mammals including humans. In contrast, θ-defensins are cyclic anti-microbial peptides made by several non-human primates but not humans. All three defensin types have anti-HIV-1 activity, but their mechanisms of action differ. We studied the anti-HIV-1 activity of one defensin from each group, HNP-1 (α), HBD-2 (β) and RTD-1 (θ). We examined how each defensin affected HIV-1 infection and demonstrated that the cyclic defensin RTD-1 inhibited HIV-1 entry, while acyclic HNP-1 and HBD-2 inhibited HIV-1 replication even when added 12 hours post-infection and blocked viral replication after HIV-1 cDNA formation. We further found that all three defensins downmodulated CXCR4. Moreover, RTD-1 inactivated X4 HIV-1, while HNP-1 and HBD-2 inactivated both X4 and R5 HIV-1. The data presented here show that acyclic and cyclic defensins block HIV-1 replication by shared and diverse mechanisms. Moreover, we found that HNP-1 and RTD-1 directly inhibited firefly luciferase enzymatic activity, which may affect the interpretation of previously published data