Dynamical Supersymmetry Breaking from Simple Quivers

We construct a simple local model of dynamical supersymmetry breaking. The model is a one generation SU(5) that arises from a IIB Z_N orientifold. It does not admit a runaway direction and is argued to stabilize the blowup mode related to the corresponding U(1) factor. The theory demonstrates the existence of a new class of "blowup" fractional branes. We further discuss a compact realization of the quiver on a Calabi-Yau 3-fold which enables one to add fluxes and stabilize the complex structure moduli.Comment: 4 pages, revtex4; An error was corrected following [arXiv:0707.0298

Susceptibility Genes in Thyroid Autoimmunity

The autoimmune thyroid diseases (AITD) are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine) is believed to initiate the autoimmune response to thyroid antigens. Abundant epidemiological data, including family and twin studies, point to a strong genetic influence on the development of AITD. Various techniques have been employed to identify the genes contributing to the etiology of AITD, including candidate gene analysis and whole genome screening. These studies have enabled the identification of several loci (genetic regions) that are linked with AITD, and in some of these loci, putative AITD susceptibility genes have been identified. Some of these genes/loci are unique to Graves' disease (GD) and Hashimoto's thyroiditis (HT) and some are common to both the diseases, indicating that there is a shared genetic susceptibility to GD and HT. The putative GD and HT susceptibility genes include both immune modifying genes (e.g. HLA, CTLA-4) and thyroid specific genes (e.g. TSHR, Tg). Most likely, these loci interact and their interactions may influence disease phenotype and severity

Permanent hypothyroidism following immune checkpoint inhibitors induced thyroiditis may be associated with improved survival: results of an explanatory study

BackgroundImmune-related endocrinopathies are common after immune checkpoint inhibitor (ICI) therapy, among which destructive thyroiditis is the most prevalent. Improved survival outcomes have been associated with immune-related adverse events. We aimed to compare the clinical course and biochemical parameters of two subtypes of ICI-related destructive thyroiditis: a transient thyrotoxicosis that reverts to either euthyroidism (TT; transient thyroiditis) versus progression to permanent hypothyroidism (PH), and to identify prognostic markers in cancer patients receiving ICI therapy who developed DT.MethodsThis retrospective observational study included 124 patients who developed a transient thyrotoxicosis due to a destructive thyroiditis after ICI therapy from January 1, 2016 to April 30, 2021 at the Montefiore Medical Center. Patients were categorized as either TT or PH based on spontaneous renormalization of the TSH or the permanent need for thyroid hormone replacement, respectively. Thyroid hormone and antibody levels, serum inflammatory markers, eosinophils, and metabolic uptake of the thyroid on PET imaging, each corresponding closest to a suppressed TSH, were characterized. Survival from TT and PH were also analyzed.ResultsOf the 124 patients, 53 developed PH and 71 developed TT. The PH group developed thyrotoxicosis at a median of 42 days from the first ICI dose while the TT group took significantly longer at 56 days. Thyroidal PET uptake was increased in 18.9% of the PH group versus 6.0% of the TT group (P=0.04). Three different survival models consistently demonstrated a trend towards increased survival in the PH group, compared to the TT group.ConclusionOur results suggest that PH developing after ICI-induced destructive thyroiditis may be associated with a more robust inflammatory and antitumor response to ICI therapy. The results suggests that PH may be a potential clinical predictor of improved survival

Glowworm Attack: Optical TEMPEST Sound Recovery via a Device’s Power Indicator LED

Two main classes of optical TEMPEST attacks against the confidentiality of information processed/delivered by devices have been demonstrated in the past two decades; the first class includes methods for recovering content from monitors, and the second class includes methods for recovering keystrokes from physical and virtual keyboards. In this paper, we identify a new class of optical TEMPEST attacks: recovering sound by analyzing optical emanations from a device’s power indicator LED. We analyze the response of the power indicator LED of various devices to sound and show that there is an optical correlation between the sound that is played by connected speakers and the intensity of their power indicator LED due to the facts that: (1) the power indicator LED of various devices is connected directly to the power line, (2) the intensity of a device’s power indicator LED is correlative to the power consumption, and (3) many devices lack a dedicated means of countering this phenomenon. Based on our findings, we present the Glowworm attack, an optical TEMPEST attack that can be used by eavesdroppers to recover sound by analyzing optical measurements obtained via an electro-optical sensor directed at the power indicator LED of various devices (e.g., speakers, USB hub splitters, and microcontrollers). We propose an optical-audio transformation (OAT) to recover sound in which we isolate the speech from optical measurements obtained by directing an electro-optical sensor at a device’s power indicator LED Finally, we test the performance of the Glowworm attack in various experimental setups and show that an eavesdropper can apply the attack to recover speech from speakers’ power LED indicator with good intelligibility from a distance of 15 meters and with fair intelligibility from 35 meters

cDNA Immunization of Mice with Human Thyroglobulin Generates Both Humoral and T Cell Responses: A Novel Model of Thyroid Autoimmunity

Thyroglobulin (Tg) represents one of the largest known self-antigens involved in autoimmunity. Numerous studies have implicated it in triggering and perpetuating the autoimmune response in autoimmune thyroid diseases (AITD). Indeed, traditional models of autoimmune thyroid disease, experimental autoimmune thyroiditis (EAT), are generated by immunizing mice with thyroglobulin protein in conjunction with an adjuvant, or by high repeated doses of Tg alone, without adjuvant. These extant models are limited in their experimental flexibility, i.e. the ability to make modifications to the Tg used in immunizations. In this study, we have immunized mice with a plasmid cDNA encoding the full-length human Tg (hTG) protein, in order to generate a model of Hashimoto's thyroiditis which is closer to the human disease and does not require adjuvants to breakdown tolerance. Human thyroglobulin cDNA was injected and subsequently electroporated into skeletal muscle using a square wave generator. Following hTg cDNA immunizations, the mice developed both B and T cell responses to Tg, albeit with no evidence of lymphocytic infiltration of the thyroid. This novel model will afford investigators the means to test various hypotheses which were unavailable with the previous EAT models, specifically the effects of hTg sequence variations on the induction of thyroiditis

Point-of-care continuous 13C-methacetin breath test improves decision making in acute liver disease: Results of a pilot clinical trial

AIM: To assess the role of the 13C-methacetin breath test (MBT) in patients with acute liver disease