Links between non-alcoholic fatty lever disease and subclinical atherosclerosis

Introduction: non-alcoholic fatty lever disease is linked to atherosclerosis due to the latest´s risk factors. There are also tendencies that affirm that there is a different factor on its pathogeny. The subclinical atherosclerosis is a preventive medicine concept, and looking for it can help finding clues for future irreversible damage. Objective: to determine the association between subclinical atherosclerosis in dyslipidemic patients with non-alcoholic fatty lever disease. Method: a descriptive, cross-sectional study was carried out in a population of 114 dyslipidemic patients with non-alcoholic fatty lever disease in the dyslipoproteinemias consultation at the Surgical Clinical Hospital ¨Hermanos Amejeiras¨ from 2016 to 2019. Results:  mean age was 52.9 ± 12.4 years, with male patients’ predominance. 62 patients showed thickening in the intima-media wider than 1mm in echocardiography, and just 8 patients had atheroma plaque in the carotid artery. The frequency of the altered lipidic profile was due to hypertriglyceridaemia and HDL cholesterol. Conclusions: no link was found between non-alcoholic fatty lever disease and subclinical atherosclerosis. Through the analysis, atherosclerosis was linked to variables as age and family history of ischemic heart disease. There is no association between subclinical atherosclerosis and the degree of progression in the non-alcoholic fatty lever disease given by the APRI index

Asociación entre enfermedad de hígado graso no alcohólico y aterosclerosis subclínica

Introduction: non-alcoholic fatty lever disease is linked to atherosclerosis due to the latest´s risk factors. There are also tendencies that affirm that there is a different factor on its pathogeny. The subclinical atherosclerosis is a preventive medicine concept, and looking for it can help finding clues for future irreversible damage.Objective: to determine the association between subclinical atherosclerosis in dyslipidemic patients with non-alcoholic fatty lever disease. Method: a descriptive, cross-sectional study was carried out in a population of 114 dyslipidemic patients with non-alcoholic fatty lever disease in the dyslipoproteinemias consultation at the Surgical Clinical Hospital ¨Hermanos Amejeiras¨ from 2016 to 2019.Results:  mean age was 52.9 ± 12.4 years, with male patients’ predominance. 62 patients showed thickening in the intima-media wider than 1mm in echocardiography, and just 8 patients had atheroma plaque in the carotid artery. The frequency of the altered lipidic profile was due to hypertriglyceridaemia and HDL cholesterol. Conclusions: no link was found between non-alcoholic fatty lever disease and subclinical atherosclerosis. Through the analysis, atherosclerosis was linked to variables as age and family history of ischemic heart disease. There is no association between subclinical atherosclerosis and the degree of progression in the non-alcoholic fatty lever disease given by the APRI index.Introducción: la enfermedad de hígado graso no alcohólico está asociada con la aterosclerosis como consecuencia de los factores de riesgo que la acompañan. Hay tendencias que apoyan que es un factor independiente en su patogenia. La aterosclerosis subclínica es un concepto de medicina preventiva y su búsqueda permite marcar la aparición futura de daños irreversibles. Objetivo: determinar la asociación de aterosclerosis subclínica en pacientes dislipidémicos con enfermedad de hígado graso no alcohólico. Método: se realizó un estudio descriptivo, transversal en 114 pacientes dislipidémicos con enfermedad de hígado graso no alcohólico de la consulta de dislipoproteinemias en el Hospital Clínico Quirúrgico “Hermanos Ameijeiras” en el período comprendido entre los años 2016 al 2019.Resultados: la media de edad fue de 52,9 ± 12,4 años con predominio del sexo masculino. En ecocardiografía, 62 pacientes con enfermedad de hígado graso no alcohólico presentaron aumento del grosor de la íntima media mayor de 1mm y solo 8 pacientes tenían placa de ateroma de la arteria carotídea. La frecuencia del perfil lipídico alterado fue a expensas de hipertrigliceridemia y de la HDL colesterol.Conclusiones: no existió asociación entre la enfermedad de hígado graso no alcohólico con aterosclerosis subclínica; mediante el análisis multivariado se encontró asociación franca de la aterosclerosis subclínica con variables como la edad y el antecedente familiar de cardiopatía isquémica. No hay asociación de aterosclerosis subclínica con el grado de progresión de enfermedad de hígado graso no alcohólico dado por el índice de APRI