The comparison of local tumor control after microwave ablation, surgical resection and combined treatment for colorectal liver metastases

Aim. We aimed to compare the local therapeutic efficiency of microwave ablation (MWA), surgical resection, and combined treatment, assess the outcomes, and identify predictive factors for local treatment response in colorectal liver metastases (CLMs). Methods. From March 2013 to September 2019, a total of 54 patients with 302 CLMs were enrolled in this retrospective study. Eleven patients (20.4%) were treated with MWA, 9 patients (16.7%) with surgery, and 34 patients (63%) with the combined method. Univariate and multivariate analyses were performed to investigate overall survival (OS) and hepatic progression-free survival (HPFS) using the Cox proportional hazard regression model. The logistic regression analysis was used to identify the predictive factors for the local treatment response. Results. Total treatment response was achieved in 46.3% (n=25) of the patients. Local tumor progression was seen in 7.4% (n=4) of the patients, and the rate of intrahepatic distal recurrence was 46.3% (n=25). There were no significant differences in HPFS and OS between the three groups (p=0.56 and 0.90, respectively). Younger age

Role of pre-transplant 18F-FDG PET/CT in predicting hepatocellular carcinoma recurrence after liver transplantation

WOS: 000450964500006PubMed ID: 30364796The last two decades have seen a paradigm shift in the selection of patients with hepatocellular carcinoma (HCC) for liver transplantation. Microvascular invasion and differentiation have been the most significant factors affecting post-transplant recurrence; however, because of inherent disadvantages of pre-transplant biopsy, histological criteria never gained popularity. Recently, the selection criteria evolved from morphological to biological criteria, such as biomarkers and response to loco-regional therapy. With the introduction of multimodality imaging, combination of computed tomography with nuclear medicine imaging, particularly, 18F-fluorodeoxyglucose positron emission tomography fulfilled an unmet need and rapidly became a critical component of HCC management. This review article will focus on the use of 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography in the pre-transplant evaluation of HCC patients with special discussion on its ability to predict HCC recurrence after liver transplantation

Is routine reconstruction for all sizeable anterior sector drainage veins necessary in right lobe living donor liver transplantation?

---International Liver Transplantation Societ

Otonom helikopterler için öğrenebilir yapay sinir ağı tabanlı olmayan adaptif kontrol algoritmalarının uçuş testleri ile doğrulanması

TÜBİTAK MAG01.05.2010Bu projede bir model helikopter için dinamik matematiksel benzetimi geliştirilmiştir. Geliştirilen benzetim yapay sinir ağı tabanlı adaptif kontrol algoritmaları ile sanal ortamda kontrol edilmiştir. Kontrolcünün model helikopter üzerinde test edilmesi için helikoptere otonom uçuş yetisi kazandırılmaya çalışılmıştır. Kontrolcünün denenmesi ve testlerin güvenli bir ortamda gerçekleştirilmesi için test platformları tasarlanmış ve testler gerçekleştirilmiştir. Aviyonik sistemler birbirleri ile entegre edilmiş ve birlikte çalıştırılmıştır. Sensörlerden gelen veriler elde edilmiş ve bu veriler kontrolcüye beslenerek model helikopterin kararlı bir şekilde askı pozisyonunda kalması hedeflenmiştir.Tüm sistem platforma monte edilmiş ve sistemlerin birbiriyle uyumlu çalışması için çalışmalar gerçekleştirilmiştir. Tüm testlerden sonra simulasyon ortamındaki verilerle testlerden elde edilen veriler karşılaştırılarak kontrol algoritmalarının doğrulanması öngörülmektedir.In this Project, a simulation model for an RC helicopter is developed. The system is tested in the laboratory with neural network based adaptive control algorithms. The helicopter is equipped with autonomous flying capability. Test platforms were designed in order to test the controller and perform these tests in a secure environment. Avionic systems were integrated with each other and operated together. Flight data was obtained from sensors and data was fed back to the controller to keep the helicopter in hover in a stable manner. The whole system was installed on the platform and studies were carried out for the operation of the sub- systems. After the tests, it is expected to verify control algorithms comparing both data obtained in the simulation environment and actal tests

Functionalization of chitosan by click chemistry

International Conference on Environment, Chemical Engineering and Materials (ECEM) -- JUN 27-29, 2017 -- Transylvania Univ Brasov, Brasov, ROMANIAWOS: 000426289700009Chitosan modification represents a challenge nowadays. The variety of compounds which can be obtained with various architectures and different functionalities made it attractive to be used in fields like pharmacy and material science. Presents study deals with the chemical modification of chitosan by using click chemistry technique. The study adopted the approach of clicking azidated chitosan with a synthesized alkyne terminated polymer i.e. poly N isopropylacrylamide with thennoresponsive properties. Structures were confirmed by the FT-IR and HNMR spectra. Thermal characterization was performed showing different thermal behaviour with the chemical modification. The final synthesized graft copolymer can play important role within pharmaceutical formulations carrying drugs for topical or oral treatments.Scientific and Technological Research Council of Turkey (TUBITAK) - Marie Curie Actions under FP7 [115C078]One author (C.Y) acknowledges the financial support from "The Scientific and Technological Research Council of Turkey (TUBITAK), CoFunded by Marie Curie Actions under FP7", project number 115C078 and Ege University, Faculty of Pharmacy, Pharmaceutical Sciences Research Centre (FABAL) for some instrumental analysis

Functionalized Chitosan for Pharmaceutical Applications

WOS: 000416527500005Background: Chitosan structure versatility toward a change in an external stimulus represents a "must have" for the pharmaceutical applications, especially for the pharmaceutical formulations. Chemical modification can open new ways to obtain materials with tailored properties. Despite the great interest for conventional graft modifications, controlled/ living free radical polymerizations (i.e. RAFT, ATRP, etc.) and advanced chemistry techniques (i.e. click chemistry) seem more attractive nowadays and involve facile and fast procedure, high regioselectivity, quantitative yield, mild reaction conditions without generation of by-products. Objective: The present review provides a detailed state of art of the chemical modification of chitosan i.e. tailored side-chain functionalization using RAFT polymerization and click chemistry for specific applications within pharmaceutical formulations taking into account the applicative aspect regarding the need of pharmaceuticals. Conclusion: The review showed the routes of current approaches for side chain modification of chitosan including graft, block copolymers or other structural variations. The esterification of RAFT agents on chitosan by using carbonyl activating reagents enables producing chitosan graft and block copolymers with controlled architectures while the development of protection/ deprotection chemistry of chitosan made possible the regioselective modification of chitosan or other polysaccharides. Although these developments increased the potential of chitosan, still the chemical functionality and architectural diversity of the derivatives are limited. Application of modern techniques e.g. RAFT polymerization, "click" chemistry has opened new "doors" for the science of controlled and chemoselective synthesis of well-tailored derivatives with unique and superior properties.The Scientific and Technological Research Council of Turkey (TUBITAK) - Marie Curie Actions under FP7 [115C078]Authors acknowledge the financial support from "The Scientific and Technological Research Council of Turkey (TUBITAK), cofunded by Marie Curie Actions under FP7", project number 115C078

How to select which anterior sector drainage veins to reconstruct in right lobe living donor liver transplantation?

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Comparison of serum maternal adiponectin concentrations in women with isolated intrauterine growth retardation and intrauterine growth retardation concomitant with pre-eclampsia

Objective: the aim of this study was to compare serum maternal adiponectin concentrations in pregnant women with isolated intrauterine growth retardation (IUGR) and in pregnant women with IUGR concomitant with pre-eclampsia (IUGRcwPE). Material and Methods: Thirty patients with isolated IUGR (group 1), 20 patients with IUGRcwPE (group 2), and 30 healthy controls (group 3) between age 18-40 were included into the study. Venous blood samples of those patients were obtained in the starving state. Adiponectin con- centrations were measured by enzyme-linked immunosorbent assay in serum obtained after centrifugation. To find the differences between the groups, student t-test and one-way ANOVA statistical methods were used. Results: There were no differences between the groups in terms of age, body mass index, gestational age, and parity (p>0.05). the values of amniotic fluid index (p<0.001) and weight gained during pregnancy (p=0.017) were significantly different when compared among the three groups. the mean concentrations of adiponectin were 94.041 pg/mL in the IUGR group, 55.717 pg/mL in the IUGRcwPE group, and 51.831 pg/mL in the control group. Both of the differences between the IUGR and IUGRcwPE groups (p value; <0.05) and IUGR and control groups were statis- tically significant (p value; <0.001). However, there were no significant differences between the IUGRcwPE group and control group (p>0.05). Conclusion: We found that IUGR increased maternal serum adiponectin concentrations; however, this rise does not occur in pregnant women with IUGRcwPE

Novel intraoperative strategies significantly reduce transfusion requirements in liver transplantation

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