In Vitro Antioxidant Activity and Phenolic Contents of the Leaves of Olax subscorpioidea and Distemonanthus benthamianus

ABSTRACT Plants are sources of natural antioxidants and some of their compounds have significant antioxidant properties and health benefits. Olaxsubscorpioidea and Distemonanthusbenthamianus are used in folk medicine for the treatment of many diseases. This study was undertaken to evaluate the in vitro antioxidant potential and the phenolic contents of the aqueous and 70% ethanolic extracts of the leaves of these plants. The antioxidant activity and phenolic contents of the aqueous and 70 %ethanolic extracts of the leaves of O.subscorpioidea and D.benthamianus were evaluated using Spectrophotometric methods for the determination of total phenols, total flavonoids, flavonols and proanthocyanidins. The antioxidant activity of the extracts was determined by the 1,1-Diphenyl-2-picrylhydrazyl, anti-lipid peroxidation, reducing power and ferrous chelating ability methods. The ethanolicextracts had the highest antioxidant activitiesand phenolic compoundslevels.D.benthamianusexhibited strong DPPH scavenging activity (IC 50 =10.87 ± 0.18),lipid peroxidation inhibition assay (IC 50 =0.97 ± 0.01 mg/mL),ferrous chelating assay (IC 50 =0.94 ± 0.02 mg/mL) added to its higher reducing power andphenolic contents (102.8±0.57 mg/g extract). Theantioxidant propertiesof these plants may explain their therapeutic activities. Our following work will explore the pharmacological potential of D. benthamianusethanolic extract

Evaluation of Antihypertensive Activity of Aqueous and Ethylic Alcohol Extracts of Stem Bark of Xylopia villosa Chipp (Annonaceae)

Abstract This study aims to evaluate Antihypertensive activity of aqueous and ethanolic extracts of Xylopia villosa stem bark. The induction of hypertension was made with adrenaline on albino rats of wistar strain. Treatments of hypertensive rats with aqueous and ethanolic extracts of Xylopia villosa at doses of 100 and 200 mg/kg bw and Atenolol (the reference molecule) at doses of 10 and 20 mg/kg bw have normalized cardiovascular parameters such as systolic blood pressure, diastolic blood pressure and heart rate. However, these doses all increased the blood concentration of Na + of hypertensive rats. Only treatments with aqueous and ethanolic extracts at a dose of 200mg/kg bw were able to bring blood concentration in K + of hypertensive rats to a concentration equivalent to that of normotensive rats