1,617 research outputs found
Thermodynamic limits of crystallization and the prediction of glass formation tendency
We have calculated the T0 curves for several Al-rare-earth binary alloys to assess the importance of the transport-based resistance to crystallization in the overall glass formation process and the general effectiveness of thermodynamic prediction of glass-forming ability. Our results show that the experimentally observed glass-forming compositions for Al-(Ce, Gd, Ho, Nd, Y, Dy) alloys strongly correlate with the composition range bounded by the T0curves associated with the relevant crystalline phases. This indicates that sluggish material transport, together with the tendency for clustering and other types of ordering at medium-range scale, is a key factor governing glass formation in these systems
An Investigation of the Differential Expression of Her2/neu Gene Expression in Normal Oral Mucosa, Epithelial Dysplasia, and Oral Squamous Cell Carcinoma in Taiwan
BackgroundHer2/neu was thought to be a proto-oncogene with sequence homology to epidermal growth factor receptor (EGFR). Its overexpression was seen in many cancers and referred to regimens of anticancer therapy. The aim of this study was to investigate whether the abnormal expression existed in oral carcinogenesis.MethodsImmunohistochemistry (IHC) was used to detect Her2/neu expression in normal oral mucosa (NOM) (n = 20), oral precancerous lesions of epithelial dysplasia (ED) (n = 20), and oral squamous cell carcinoma (OSCC) (n = 30). The association of clinicopathologic covariates of areca use, tumor size, neck lymph node metastasis, differentiation and stages of cancer with the expression of Her2/neu was examined. The significance of Neu immunoreactivity in different groups or with different covariates was investigated using Fisher's exact test.ResultsHer2/neu immunoreactivity was very low with Her2/neu(+) in 10% (2/20) of NOM cases and in 25% (5/20) of ED cases, respectively. The Her2/neu expression was high in OSCC cases, with 40% (12/30) of Her2/neu(+) and 10% (3/30) of Her2/neu(++). Significant difference was observed between NOM/ED and OSCC cases (p < 0.05). All clinicopathologic covariates showed no significant relation to the expression of Her2/neu in OSCC cases.ConclusionThese findings suggested a dynamic change in Her2/neu expression during the development of OSCC. The overexpression of Her2/neu can be used as a marker in distinguishing NOM/ED from OSCC
Gutzwiller Hybrid Quantum-Classical Computing Approach for Correlated Materials
Rapid progress in noisy intermediate-scale quantum (NISQ) computing
technology has led to the development of novel resource-efficient hybrid
quantum-classical algorithms, such as the variational quantum eigensolver
(VQE), that can address open challenges in quantum chemistry, physics and
material science. Proof-of-principle quantum chemistry simulations for small
molecules have been demonstrated on NISQ devices. While several approaches have
been theoretically proposed for correlated materials, NISQ simulations of
interacting periodic models on current quantum devices have not yet been
demonstrated. Here, we develop a hybrid quantum-classical simulation framework
for correlated electron systems based on the Gutzwiller variational embedding
approach. We implement this framework on Rigetti quantum processing units
(QPUs) and apply it to the periodic Anderson model, which describes a
correlated heavy electron band hybridizing with non-interacting conduction
electrons. Our simulation results quantitatively reproduce the known ground
state quantum phase diagram including metallic, Kondo and Mott insulating
phases. This is the first fully self-consistent hybrid quantum-classical
simulation of an infinite correlated lattice model executed on QPUs,
demonstrating that the Gutzwiller hybrid quantum-classical embedding framework
is a powerful approach to simulate correlated materials on NISQ hardware. This
benchmark study also puts forth a concrete pathway towards practical quantum
advantage on NISQ devices.Comment: 14 pages, 5 figure
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