1,276 research outputs found
Genome-Wide Association and Linkage Analysis of Quantitative Traits: Comparison pf Likelihood-Ratio Test and Conditional Score Statistic
Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods.National Institutes of Health (National Institute of General Medical Sciences R01 GM031575, National Center for Research Resources Shared Instrumentation grant 1S10RR163736-01A1
Effect of Sinusoidal Surface Roughness and Energy on the Orientation of Cylinder-Forming Block Copolymer Thin Films
We explore the relative stability of three possible orientations of
cylinder-forming di-block copolymer on a sinusoidally corrugated substrate. The
cylinders can be aligned either parallel to the substrate, with their long axis
being oriented along or orthogonal to the corrugation trenches, or
perpendicular to the substrate. Using self-consistent field theory, we
investigate the influence of substrate roughness and surface preference on the
phase transition between the three orientations. When the substrate preference,
, towards one of components is small, increasing the substrate roughness
induces a phase transition from parallel to perpendicular cylindrical phase.
However, when is large, the parallel orientation is more stable than the
perpendicular one. Within this parallel phase, increasing the substrate
roughness leads to a transition of cylinder orientation changing from being
orthogonal to parallel to the trench long axis. Increasing the substrate
preference leads to an opposite transition from parallel to orthogonal to the
trenches. Furthermore, we predict that the perpendicular cylinder phase is
easier to be obtained when the unidirectional corrugation is along the longer
unit vector of the hexagonal packing than when it is along the shorter unit
vector. Our results qualitatively agree with previous experiments, and
contribute towards applications of the cylinder-forming block copolymer in
nanotechnology.Comment: 9 pages, 7 figure
Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic
Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods
Investigation and improvement of DNA cleavage models of polyamide + Cu(II) nuclease + OOH- ligands bound to DNA
- âŚ