Achievements and Challenges in Improving Air Quality in China: Analysis of the Long-Term Trends from 2014 to 2022

Due to the implementation of air pollution control measures in China, air quality has significantly improved, although there are still additional issues to be addressed. This study used the long-term trends of air pollutants to discuss the achievements and challenges in further improving air quality in China. The Kolmogorov-Zurbenko (KZ) filter and multiple-linear regression (MLR) were used to quantify the meteorology-related and emission-related trends of air pollutants from 2014 to 2022 in China. The KZ filter analysis showed that PM2.5 decreased by 7.36 ± 2.92% yr􀀀 1, while daily maximum 8-h ozone (MDA8 O3) showed an increasing trend with 3.71 ± 2.89% yr􀀀 1 in China. The decrease in PM2.5 and increase in MDA8 O3 were primarily attributed to changes in emission, with the relative contribution of 85.8% and 86.0%, respectively. Meteorology variations, including increased ambient temperature, boundary layer height, and reduced relative humidity, also contributed to the reduction of PM2.5 and the enhancement of MDA8 O3. The emission-related trends of PM2.5 and MDA8 O3 exhibited continuous decrease and increase, respectively, from 2014 to 2022, while the variation rates slowed during 2018–2020 compared to that during 2014–2017, highlighting the challenges in further improving air quality, particularly in simultaneously reducing PM2.5 and O3. This study recommends reducing NH3 emissions from the agriculture sector in rural areas and transport emissions in urban areas to further decrease PM2.5 levels. Addressing O3 pollution requires the reduction of O3 precursor gases based on site-specific atmospheric chemistry considerations

Implications of Epigenetic Drift in Colorectal Neoplasia

NIH grants U01CA182940 (G.E. Luebeck, W.D. Hazelton, W.M. Grady, S.K. Madden, K. Curtius), U01CA199336 (G.E. Luebeck, W.D. Hazelton); Barts Charity grant 472-2300, London (K. Curtius) and UK Medical Research Council Rutherford fellowship (K. Curtius); and NIH grants (P30CA15704, U01CA152756, R01CA194663, R01CA220004, U54CA143862, P01CA077852),R.A.C.E. Charities, Cottrell Family Fund, R03CA165153, Listwin Family Foundation, Seattle Translational Tumor Research program, Fred Hutchinson Cancer Research Center (S.K. Madden, M. Yu, K.T. Carter, and W.M. Grady), R01CA189184 (C. Lee, C.M. Ulrich, S.K.Madden, M. Yu, K.T. Carter, and W.M. Grady), R01CA112516, R01CA114467, R01CA120523 (C.M. Ulrich, S.K. Madden, M. Yu, K.T. Carter, and W.M. Grady), Huntsman Cancer Foundation, U01 CA206110, R01CA189184 R01CA 207371 and P30CACA042014 (C.M. Ulrich). U24CA074794 (P.A. Newcomb, S.K. Madden, M. Yu, K.T. Carter, and W.M. Grady). This material is the result of work supported in part by resources from the VA Puget Sound Health Care System and the ColoCare Study

Praziquantel Facilitates IFN-γ-Producing CD8+ T Cells (Tc1) and IL-17-Producing CD8+ T Cells (Tc17) Responses to DNA Vaccination in Mice

BACKGROUND: CD8(+) cytotoxic T lymphocytes (CTLs) are crucial for eliminating hepatitis B virus (HBV) infected cells. DNA vaccination, a novel therapeutic strategy for chronic virus infection, has been shown to induce CTL responses. However, accumulated data have shown that CTLs could not be effectively induced by HBV DNA vaccination. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report that praziquantel (PZQ), an anti-schistoma drug, could act as an adjuvant to overcome the lack of potent CTL responses by HBV DNA vaccination in mice. PZQ in combination with HBV DNA vaccination augmented the induction of CD8(+) T cell-dependent and HBV-specific delayed hypersensitivity responses (DTH) in C57BL/6 mice. Furthermore, the induced CD8(+) T cells consisted of both Tc1 and Tc17 subtypes. By using IFN-γ knockout (KO) mice and IL-17 KO mice, both cytokines were found to be involved in the DTH. The relevance of these findings to HBV immunization was established in HBsAg transgenic mice, in which PZQ also augmented the induction of HBV-specific Tc1 and Tc17 cells and resulted in reduction of HBsAg positive hepatocytes. Adoptive transfer experiments further showed that PZQ-primed CD8(+) T cells from wild type mice, but not the counterpart from IFN-γ KO or IL-17 KO mice, resulted in elimination of HBsAg positive hepatocytes. CONCLUSIONS/SIGNIFICANCE: Our results suggest that PZQ is an effective adjuvant to facilitate Tc1 and Tc17 responses to HBV DNA vaccination, inducing broad CD8(+) T cell-based immunotherapy that breaks tolerance to HBsAg

Evaluate the Impact of Cold Wave on Face Slab Cracking Using Fuzzy Finite Element Method

We use fuzzy finite element method (FEM) to analyze the impact of cold wave on face slab cracking of a concrete-faced rockfill dam (CFRD). The static response of dam and the temperature field of face slab are calculated using deterministic FEM since some observed and test data can be obtained. Some parameters of Goodman contact element between face slabs and cushion material are selected as fuzzy variables, and the fuzzy FEM is used to calculate fuzzy stress of face slab. The fuzzy FEM is implemented using vertex method based on the extension principle. Through the analysis of two selected calculation cases of cold wave, it is shown that the calculated cracking direction and cracking zone caused by thermal stress are similar to those of the observed cracks. This proves that the cold wave that caused swift air temperature drop is an important reason for the cracking of face slab. According to these analysis results, some cracking prevention measures are then proposed

Structural Modal Parameter Identification Method Based on the Delayed Transfer Rate Function under Periodic Excitations

The dynamic response transfer rate function (TRF) is increasingly used in the field of structural modal parameter identification because it does not depend on the white noise assumption of the excitation. In this paper, the interference of periodic excitation on structural modal parameter identification using TRF is analyzed theoretically for a class of civil engineering structures with obvious periodic components in excitation, and then an identification method of structural real modal parameters is proposed. First, a delayed TRF is constructed, and the pseudo-frequency response function is further obtained to identify the periodic spurious poles of the whole system. Then, the effective identification of the real modal parameters of the structure is achieved by comparing the system poles identified via conventional TRF. Finally, the feasibility and robustness of the proposed method were verified using a calculation example with four-degrees-of-freedom system. In addition, the modal parameters of a structure under periodic excitation were effectively identified by taking a pumping station as an example, and the results show that the method accurately identified the structural modal parameters when the excitation contained periodic components, which has wider prospects for technical applications

Adaptive Finite-Time Congestion Control for Uncertain TCP/AQM Network with Unknown Hysteresis

The issue of adaptive practical finite-time (FT) congestion control for the transmission control protocol/active queue management (TCP/AQM) network with unknown hysteresis and external disturbance is considered in this paper. A finite-time congestion controller is designed by the backstepping technique and the adaptive neural control method. This controller guarantees that the queue length tracks the desired queue in finite-time, and it is semiglobally practical finite-time stable (SGPFS) for all the signals of the closed-loop system. At last, the simulation results show that the control strategy is effective

Genesis Analysis of Special Deformation Characteristics for Super-High Arch Dams in the Alpine and Gorge Regions of Southwest China

During the operational period, unexpected upstream deformation has been observed in several super-high arch dams located in the alpine and gorge regions. In addition, the phenomenon of the downstream dam deformation monitoring values being apparently smaller than the numerical simulation results appears in some super-high arch dams. This paper focuses on the genetic mechanism of a super-high arch dam’s special deformation characteristics. The finite element method (FEM) was used to analyze the effects of solar radiation, valley contraction, and overhanging on super-high arch dam’s deformation behavior. First, the influences of solar radiation on the temperature field and deformation characteristics of the super-high arch dam under the shading effects of the mountain and the dam body were investigated. Second, the impacts of valley contraction on the deformation characteristics of the super-high arch dam during the storage period were studied. Subsequently, the impact of the overhanging effect on the super-high arch dam’s deformation was explored. Finally, a case study was conducted on the basis of the Jinping I super-high arch dam to evaluate the effectiveness of the proposed analytical method. It is indicated that the dam’s special deformation can be explained reasonably. Above all, in order to accurately analyze and predict the deformation characteristics of super high-arch dams in the alpine and gorge regions of Southwest China, solar radiation, valley contraction, and the dam-overhanging effect need to be considered as influencing factors of dam deformation