Brain and Eye Abnormalities Following Prenatal LSD Ingestion

Eye deformities; CNS deformationsA 13-month old infant with multiple eye and central nervous system deformities. Maternal history significant as the infant was born to a 19-year old mother who had used lysergic acid diethylamide and marijuana throughout her pregnancy.The baby made no developmental progress.N/ACongenital abnormalitiesN/A1. Aase, J.M., Laestadius, N. and Smith, D.W., Children of Mothers Who Took LSD in Pregnancy. Lancet 1: 100, 1970. 2. Eller, J.L. and Morton, J.M., Bizarre Deformities in Offspring of User of Lysergic Acid Diethylamide. New Eng. J, Med. 238: 395-397, 1970. 3. Hanaway, J.K.: LSD: Effects on Developing Mouse Lens. Science 164: 574-575, 1969. 4. Roux, C., Duperis, R. and Aubry, M. : LSD: No Teratogenic Action in Rats, Mice and Hamsters. Science 169: 588, 1970. 5. Yanoff, M., Rahn, E.K. and Zimmerman, L.E.: Histopathology of Juvenile Retinoschisis. Arch. Ophthal. 79: 49-53, 1968

Ocular Involvement with Dawson's Inclusion Body Encephalitis or SSPE (Subacute Sclerosing Panencephalitis)

Loss of visionTwo teenage girls died from a progressive neurological disease.N/AN/AEdematous central macular retinopathyN/AN/

Ocular and Cerebral Abnormalities in 18 Chromosome Deletion Defect

N/AA 3400 gram black neonate born to a 40-year old with ischemic heart disease, low estriol levels and gestational diabetes.At parturition, the baby's eyes could not be seen or felt although small eyelids were present.N/ABilateral microphthalmos with cystN/AN/

Panopthalmitis in a Microcephalic Infant

Widely dilated pupils unresponsive to light; Irregular left pupil; Bilateral non-attachment of the retinaA 1.7 kg. male infant born to a 29-year old woman after a 42-week gestation. At 11 days rapid proptosis and eye rupture.Microcephalua with closed fontanelles and overriding sutures.Congenital malformationsN/

Update in Pathological Diagnosis of Orbital Infections and Inflammations

Orbital infections and inflammations include a broad spectrum of orbital diseases that can be idiopathic, infectious, from primary or secondary inflammatory processes. Being able to properly diagnose and manage these orbital diseases in a timely manner can avoid permanent vision loss and possibly save a patient's life. When clinicians are faced with such patients, quite often the exact diagnosis cannot be made just based on clinical examination, various laboratory tests and imaging are needed. Moreover, orbital biopsies with histopathological analyses are often required, especially for the atypical cases. Thus, it is important for the clinicians to be familiar with the pathological features and characteristics of these orbital diseases. This review provides a comprehensive update on the clinical and pathological diagnosis of these orbital infections and inflammations