Effective and Efficient Evolutionary Many-Objective Optimization

This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonMany-objective optimization is core to both artificial intelligence and data analytics as real-world problems commonly involve multiple objectives which are required to be optimized simultaneously. A large number of evolutionary algorithms have been developed to search for a set of Pareto optimal solutions for many-objective optimization problems. It is very rare that a many-objective evolutionary algorithm performs well in terms of both effectiveness and efficiency, two key evaluation criteria. Some algorithms may struggle to guide the solutions towards the Pareto front, e.g., Pareto-based algorithms, while other algorithms may have difficulty in diversifying the solutions evenly over the front on certain problems, e.g., decomposition-based algorithms. Furthermore, some effective algorithms may become very computationally expensive as the number of objectives increases, e.g., indicator-based algorithms. The aim of this thesis is to investigate how to make evolutionary algorithms perform well in terms of effectiveness and efficiency in many-objective optimization. After conducting a review of key concepts and the state of the art in the evolutionary many-objective optimization, this thesis shows how to improve the effectiveness of conventional Pareto-based algorithms on a challenging real-world problem in software engineering. This thesis then explores how to further enhance the effectiveness of leading many-objective evolutionary algorithms in general by extending the capability of a very popular and widely cited bi-goal evolution method. Last but not least, this thesis investigates how to strike a balance between effectiveness and efficiency of evolutionary algorithms when solving many-objective optimization problems. The work reported is based on either real-world or recognized synthetic datasets, and the proposed algorithms are compared and evaluated against leading algorithms in the field. The work does not only demonstrate ways of improving the effectiveness and efficiency of many-objective optimization algorithms but also led to promising areas for future research

Progress on Optical Fiber Biochemical Sensors Based on Graphene

Graphene, a novel form of the hexagonal honeycomb two-dimensional carbon-based structural material with a zero-band gap and ultra-high specific surface area, has unique optoelectronic capabilities, promising a suitable basis for its application in the field of optical fiber sensing. Graphene optical fiber sensing has also been a hotspot in cross-research in biology, materials, medicine, and micro-nano devices in recent years, owing to prospective benefits, such as high sensitivity, small size, and strong anti-electromagnetic interference capability and so on. Here, the progress of optical fiber biochemical sensors based on graphene is reviewed. The fabrication of graphene materials and the sensing mechanism of the graphene-based optical fiber sensor are described. The typical research works of graphene-based optical fiber biochemical sensor, such as long-period fiber grating, Bragg fiber grating, no-core fiber and photonic crystal fiber are introduced, respectively. Finally, prospects for graphene-based optical fiber biochemical sensing technology will also be covered, which will provide an important reference for the development of graphene-based optical fiber biochemical sensors

A Review of the Engineering Role of Burrowing Animals: Implication of Chinese Pangolin as an Ecosystem Engineer

Ecosystem engineers are organisms that alter the distribution of resources in the environment by creating, modifying, maintaining and/or destroying the habitat. They can affect the structure and function of the whole ecosystem furthermore. Burrowing engineers are an important group in ecosystem engineers as they play a critical role in soil translocation and habitat creation in various types of environment.However, few researchers have systematically summarized and analyzed the studies of burrowing engineers. We reviewing the existing ecological studies of burrowing engineer about their interaction with habitat through five directions: (1) soil turnover; (2)changing soil physicochemical properties; (3) changing plant community structure; (4) providing limited resources for commensal animals;and/or (5) affecting animal communities. The Chinese pangolin (Manis pentadactyla) is a typical example of burrowing mammals, in part (5), we focus on the interspecific relationships among burrow commensal species of Chinese pangolin. The engineering effects vary with environmental gradient, literature indicates that burrowing engineer play a stronger role in habitat transformation in the tropical and subtropical areas.The most common experiment method is comparative measurements (include different spatial and temporal scale),manipulative experiment is relatively few. We found that most of the engineering effects had positive feedback to the local ecosystem, increased plant abundance and resilience, increased biodiversity and consequently improved ecosystem functioning. With the global background of dramatic climate change and biodiversity loss in recent decades, we recommend future studies should improving knowledge of long-term engineering effects on population scale and landscape scale, exploring ecological cascades through trophic and engineering pathways, to better understand the attribute of the burrowing behavior of engineers to restore ecosystems and habitat creation. The review is presented as an aid to systematically expound the engineering effect of burrowing animals in the ecosystem, and provided new ideas and advice for planning and implementing conservation management

Late Cretaceous to Late Eocene Exhumation in the Nima Area, Central Tibet:Implications for Development of Low Relief Topography of the Tibetan Plateau

Much of the interior of the Tibetan Plateau is characterized by internal drainage, low relief topography, and high altitude. How and when this landscape formed is controversial. In this study, we use new zircon U-Pb data and low-temperature thermochronological data (apatite and zircon [U-Th/He], apatite fission track [AFT]) from the Late Cretaceous to Cenozoic Nima Basin sedimentary rocks and Xiabie granite in the adjacent Muggar Thrust hanging wall (part of the regional Shiquanhe-Gaize-Amdo thrust system), to determine the paleodrainage and timing of exhumation in the region. Individual AHe and ZHe cooling ages range from 9 to 60 Ma and 58 to 118 Ma, and the AFT ages range from 30 to 90 Ma. The thermal history derived from the Northern Nima Basin sediments and Xiabie granite require a period of exhumation between 70 and 40 Ma in the thrust fault hanging wall, and 40 and 30 Ma in the Nima Basin. Across the region, this event was followed by low rates of exhumation and the deposition of locally sourced sediment, lacustrine, and evaporitic deposits that are indicative of an internal drainage system. We suggest that the exhumation event is associated with development of thrust-elevated relief that may have disrupted the drainage network favoring the development of an endorheic system. This system, sediment accumulation, and/or post-30 Ma tectonic quiescence led to the generation of low relief topography

Reflexiones en torno a la Justicia restaurativa en el ámbito del menor infractor

Las políticas públicas en materia de justicia restaurativa en justicia de menores: análisis comparado entre Comunidades Autónomas / Verónica Viñas Chiappini, Helena Soleto y Marta Villar de Oro (pp. 7-56). -- El abogado defensor del menor ante la justicia restaurativa / Lucía Bielsa Casado (pp. 57-111). -- Mediación en los delitos cometidos por menores a través de las TIC / María del Carmen Borrallo Torres (pp. 113-151). -- Aportaciones al sistema ecuatoriano de justicia restaurativa de menores, desde la perspectiva del Derecho internacional y comparado / Eva María Franco Muñoz (pp. 153-184). -- Una propuesta de integración de la justicia restaurativa de menores en China / Yani Xue (pp. 185-225)

The Lysine Demethylase dKDM2 Is Non-essential for Viability, but Regulates Circadian Rhythms in Drosophila

Post-translational modification of histones, such as histone methylation controlled by specific methyltransferases and demethylases, play critical roles in modulating chromatin dynamics and transcription in eukaryotes. Misregulation of histone methylation can lead to aberrant gene expression, thereby contributing to abnormal development and diseases such as cancer. As such, the mammalian lysine-specific demethylase 2 (KDM2) homologs, KDM2A and KDM2B, are either oncogenic or tumor suppressive depending on specific pathological contexts. However, the role of KDM2 proteins during development remains poorly understood. Unlike vertebrates, Drosophila has only one KDM2 homolog (dKDM2), but its functions in vivo remain elusive due to the complexities of the existing mutant alleles. To address this problem, we have generated two dKdm2 null alleles using the CRISPR/Cas9 technique. These dKdm2 homozygous mutants are fully viable and fertile, with no developmental defects observed under laboratory conditions. However, the dKdm2 null mutant adults display defects in circadian rhythms. Most of the dKdm2 mutants become arrhythmic under constant darkness, while the circadian period of the rhythmic mutant flies is approximately 1 h shorter than the control. Interestingly, lengthened circadian periods are observed when dKDM2 is overexpressed in circadian pacemaker neurons. Taken together, these results demonstrate that dKdm2 is not essential for viability; instead, dKDM2 protein plays important roles in regulating circadian rhythms in Drosophila. Further analyses of the molecular mechanisms of dKDM2 and its orthologs in vertebrates regarding the regulation of circadian rhythms will advance our understanding of the epigenetic regulations of circadian clocks

FabSim3: An automation toolkit for verified simulations using high performance computing

A common feature of computational modelling and simulation research is the need to perform many tasks in complex sequences to achieve a usable result. This will typically involve tasks such as preparing input data, pre-processing, running simulations on a local or remote machine, post-processing, and performing coupling communications, validations and/or optimisations. Tasks like these can involve manual steps which are time and effort intensive, especially when it involves the management of large ensemble runs. Additionally, human errors become more likely and numerous as the research work becomes more complex, increasing the risk of damaging the credibility of simulation results. Automation tools can help ensure the credibility of simulation results by reducing the manual time and effort required to perform these research tasks, by making more rigorous procedures tractable, and by reducing the probability of human error due to a reduced number of manual actions. In addition, efficiency gained through automation can help researchers to perform more research within the budget and effort constraints imposed by their projects. This paper presents the main software release of FabSim3, and explains how our automation toolkit can improve and simplify a range of tasks for researchers and application developers. FabSim3 helps to prepare, submit, execute, retrieve, and analyze simulation workflows. By providing a suitable level of abstraction, FabSim3 reduces the complexity of setting up and managing a large-scale simulation scenario, while still providing transparent access to the underlying layers for effective debugging. The tool also facilitates job submission and management (including staging and curation of files and environments) for a range of different supercomputing environments. Although FabSim3 itself is application-agnostic, it supports a provably extensible plugin system where users automate simulation and analysis workflows for their own application domains. To highlight this, we briefly describe a selection of these plugins and we demonstrate the efficiency of the toolkit in handling large ensemble workflows

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake